Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice.

scientific article published on 23 February 2018

Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.RA117.001474
P932PMC publication ID5892582
P698PubMed publication ID29475944

P2093author name stringRan Li
Junling Jia
Xiaoling Li
Hai Song
Qingzhe Wu
Liansheng Liu
Ailing Wu
Jinqiu Lu
Mujun Zhao
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlQ24522941
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Brefeldin A: insights into the control of membrane traffic and organelle structureQ24643698
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dyneinQ24678185
Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor.Q27934820
Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeatsQ28261729
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell lossQ28274165
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Disregulated RhoGTPases and Actin Cytoskeleton Contribute to the Migration Defect in Lis1-Deficient NeuronsQ28507967
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinaseQ28508079
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organizationQ28585571
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motilityQ28589799
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermisQ28591979
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethalityQ28592982
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetesQ29615503
Molecular mediators of hepatic steatosis and liver injuryQ29616709
Retrograde transport from endosomes to the trans-Golgi networkQ29617826
Treatment of nonalcoholic fatty liver disease: role of AMPK.Q30248230
Epidemiology and natural history of non-alcoholic steatohepatitisQ30449204
Dictyostelium LIS1 is a centrosomal protein required for microtubule/cell cortex interactions, nucleus/centrosome linkage, and actin dynamicsQ30475931
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephalyQ30490856
LIS1 and NudE induce a persistent dynein force-producing stateQ30494782
Lis1 is an initiation factor for dynein-driven organelle transport.Q30518558
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemiaQ30608477
Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretionQ33863614
Lis1 is required for the expansion of hematopoietic stem cells in the fetal liverQ34008432
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesityQ34181503
Motoring around the GolgiQ34932451
Human fatty liver disease: old questions and new insightsQ35588477
Endoplasmic reticulum stress in liver diseaseQ36031838
The role of the liver in metabolic homeostasis: Implications for inborn errors of metabolismQ36816743
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in miceQ37170811
Acute lymphoblastic leukemia in a patient with Miller-Dieker syndromeQ37319375
Nutritional related liver disease: targeting the endoplasmic reticulum stressQ37591100
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connectionQ37739949
Protein sorting receptors in the early secretory pathwayQ37763713
Animal models of nonalcoholic fatty liver diseaseQ37814048
Role of endoplasmic reticulum stress in metabolic disease and other disorders.Q37976132
Aneuploidy, polyploidy and ploidy reversal in the liverQ38075371
Hepatic energy metabolism in human diabetes mellitus, obesity and non-alcoholic fatty liver diseaseQ38114744
LIS1 functions in normal development and diseaseQ38131212
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disordersQ38636750
The human LIS1 is downregulated in hepatocellular carcinoma and plays a tumor suppressor functionQ39543241
Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division.Q40378746
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division.Q43072719
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalitiesQ43552270
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver diseaseQ44934521
Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentationQ46980149
Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.Q50570892
Gallbladder cancer in a patient with Miller-Dieker syndromeQ56231041
Observations of the Binucleate Cells of the LiverQ59001946
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectlissencephalyQ1544416
P304page(s)5160-5171
P577publication date2018-02-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleHepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice.
P478volume293

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