STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.

scientific article published in May 2018

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2018.04.003
P932PMC publication ID6003617
P698PubMed publication ID29719256

P50authorDaniel A. PortnoyQ26737169
Erik S Van DisQ61124739
P2093author name stringChris S Rae
Tom Evans
Nathalie Cadieux
Sarah A Stanley
Thomas W Dubensky
Sarah M McWhirter
Kartoosh Heydari
David B Kanne
Jacob R Bruml
Justin J Leong
Kelsey E Sivick
Ken Metchette
Kimberly M Sogi
Meredith L Leong
Natalie H Surh
Vivian Chen
P2860cites workRoles of cyclic diguanylate in the regulation of bacterial pathogenesisQ24656979
Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvantsQ27025822
A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivoQ27349862
The HyVac4 subunit vaccine efficiently boosts BCG-primed anti-mycobacterial protective immunityQ28727776
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infectionQ29616521
Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotidesQ21132463
Activation of STAT6 by STING is critical for antiviral innate immunityQ24293312
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
STING is a direct innate immune sensor of cyclic di-GMPQ24633648
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMPQ24642631
MF59. Design and evaluation of a safe and potent adjuvant for human vaccinesQ40408021
Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.Q41181573
IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection.Q41764389
Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newbornsQ41775340
One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analoguesQ42732138
The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvantQ43198955
Bis-(3',5')-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvantQ44205583
Bacterial c-di-GMP is an immunostimulatory moleculeQ44754791
c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection.Q46030297
Interrupted BCG vaccination is a major threat to global child healthQ46650004
Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosisQ47141135
Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant proteinQ47371281
Vaccines for the twenty-first century society.Q51664205
A multistage tuberculosis vaccine that confers efficient protection before and after exposure.Q54391413
MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.Q54487555
The Development and Impact of Tuberculosis VaccinesQ56766328
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challengeQ58518610
Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6Q58827826
The bacterial second messenger cyclic diGMP exhibits potent adjuvant propertiesQ79450264
3',5'-Cyclic diguanylic acid elicits mucosal immunity against bacterial infectionQ84250609
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trialQ29620144
Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in miceQ30402980
Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analysesQ31156691
Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirementsQ33367582
Cutting edge: control of Mycobacterium tuberculosis infection by a subset of lung parenchyma-homing CD4 T cellsQ33566339
Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection.Q33619034
Evaluation of new vaccines in the mouse and guinea pig model of tuberculosisQ33755534
Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigensQ34003037
ESAT-6 subunit vaccination against Mycobacterium tuberculosisQ34003301
Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6.Q34007101
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotidesQ34151349
STING and the innate immune response to nucleic acids in the cytosolQ34317532
IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is availableQ34432140
Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosisQ34629227
Regulation of adaptive immunity by the innate immune systemQ34659642
STING ligand c-di-GMP improves cancer vaccination against metastatic breast cancerQ34687752
A defined tuberculosis vaccine candidate boosts BCG and protects against multidrug-resistant Mycobacterium tuberculosisQ35033838
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.Q35263440
A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.Q35328612
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and ImmunityQ35634752
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate AutophagyQ35738682
The importance of adjuvant formulation in the development of a tuberculosis vaccineQ35783475
Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants.Q35836140
The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvantQ36097099
Cyclic di-GMP stimulates protective innate immunity in bacterial pneumoniaQ36097274
The success and failure of BCG - implications for a novel tuberculosis vaccineQ36191944
T-cell activation is an immune correlate of risk in BCG vaccinated infantsQ36799172
Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidatesQ36909492
The host STING pathway at the interface of cancer and immunityQ37042237
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.Q37109444
Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lungQ37666257
Tuberculosis vaccine development at a divideQ38195728
Protective effect of a tuberculosis subunit vaccine based on a fusion of antigen 85B and ESAT-6 in the aerosol guinea pig modelQ38449050
Novel approaches to tuberculosis vaccine developmentQ38999845
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and ReactivationQ40133620
P433issue5
P921main subjectMycobacterium tuberculosisQ130971
P304page(s)1435-1447
P577publication date2018-05-01
P1433published inCell ReportsQ5058165
P1476titleSTING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.
P478volume23

Reverse relations

cites work (P2860)
Q92227095A SNP upstream of the cyclic GMP-AMP synthase (cGAS) gene protects from relapse and extra-pulmonary TB and relates to BCG vaccination status in an Indian cohort
Q92597111Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity
Q64256617Cell Differentiation Degree as a Factor Determining the Role for Different T-Helper Populations in Tuberculosis Protection
Q93168696Comparison of adjuvants to optimize influenza neutralizing antibody responses
Q92267263DNA sensing by the cGAS-STING pathway in health and disease
Q93013037Diminished stimulator of interferon genes production with cigarette smoke-exposure contributes to weakened anti-adenovirus vectors response and destruction of lung in chronic obstructive pulmonary disease model
Q62736465Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection
Q100305090Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants
Q94921871Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
Q91890877STING signaling and host defense against microbial infection
Q90147842Selection of adjuvants for vaccines targeting specific pathogens

Search more.