scholarly article | Q13442814 |
P50 | author | Daniel A. Portnoy | Q26737169 |
Mamoru Hyodo | Q56259636 | ||
John-Demian Sauer | Q56433698 | ||
P2093 | author name string | Kathryn M Monroe | |
Yoshihiro Hayakawa | |||
Chris S Rae | |||
Russell E Vance | |||
Joshua J Woodward | |||
Sky W Brubaker | |||
Jakob von Moltke | |||
Katia Sotelo-Troha | |||
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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response | Q24317784 | ||
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling | Q24336398 | ||
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response | Q24616827 | ||
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P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Listeria monocytogenes | Q292015 |
bites and stings | Q54911704 | ||
P304 | page(s) | 688-694 | |
P577 | publication date | 2010-11-22 | |
P1433 | published in | Infection and Immunity | Q6029193 |
P1476 | title | The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides | |
P478 | volume | 79 |
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Q34303159 | 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential |
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Q59350365 | A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice |
Q37048094 | A structural comparison of Listeria monocytogenes protein chaperones PrsA1 and PrsA2 reveals molecular features required for virulence |
Q89721924 | ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1) |
Q40438700 | AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling |
Q58700139 | ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING |
Q38450651 | Activation and regulation of DNA-driven immune responses |
Q35523204 | Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes |
Q47227792 | Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation |
Q38718753 | Activity of the Pore-Forming Virulence Factor Listeriolysin O Is Reversibly Inhibited by Naturally Occurring S-Glutathionylation. |
Q39066391 | Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade |
Q35128803 | An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence |
Q34170436 | An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria |
Q56752824 | Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function |
Q35936773 | Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling |
Q24338728 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling |
Q35183935 | Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling |
Q34871958 | Attenuated Listeria monocytogenes vectors overcome suppressive plasma factors during HIV infection to stimulate myeloid dendritic cells to promote adaptive immunity and reactivation of latent virus |
Q92179904 | Autophagy induction via STING trafficking is a primordial function of the cGAS pathway |
Q35439832 | Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages |
Q90204208 | Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response |
Q36922906 | Binding of bacterial secondary messenger molecule c di-GMP is a STING operation |
Q35238345 | Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. |
Q38048367 | Biofilm infections, their resilience to therapy and innovative treatment strategies |
Q39254592 | Both STING and MAVS fish orthologs contribute to the induction of interferon mediated by RIG-I |
Q37029731 | CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer |
Q37252611 | Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer |
Q28555172 | Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection |
Q90690167 | Cellular cytotoxicity is a form of immunogenic cell death |
Q90212898 | Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death |
Q33927128 | Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming |
Q40767216 | Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex |
Q27681354 | Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP |
Q36143536 | Crystallization studies of the murine c-di-GMP sensor protein STING. |
Q41770853 | Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses |
Q35019491 | Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation |
Q40339226 | Cyclic Dinucleotides in the Scope of the Mammalian Immune System |
Q41116868 | Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis |
Q37425019 | Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response |
Q37545670 | Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae. |
Q36873790 | Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection |
Q38118107 | Cyclic di-AMP: another second messenger enters the fray |
Q24338485 | Cyclic di-GMP sensing via the innate immune signaling protein STING |
Q37951094 | Cyclic di-GMP, an established secondary messenger still speeding up. |
Q28541732 | Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes |
Q26850396 | Cyclic di-GMP: the first 25 years of a universal bacterial second messenger |
Q37940637 | Cyclic di-nucleotides: new era for small molecules as adjuvants. |
Q38880241 | Cyclic diguanylate signaling in Gram-positive bacteria |
Q37597305 | Cyclic dinucleotides and the innate immune response |
Q28246926 | Cytoplasmic DNA innate immune pathways |
Q27022855 | Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA |
Q64131748 | Cytosolic DNA-sensing immune response and viral infection |
Q26751063 | Cytosolic Innate Immune Sensing and Signaling upon Infection |
Q58774511 | Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy |
Q26852473 | Cytosolic sensing of viruses |
Q55207475 | DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection. |
Q38073511 | DNA recognition in immunity and disease |
Q48370424 | DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity |
Q36182882 | Decreased Expression of TMEM173 Predicts Poor Prognosis in Patients with Hepatocellular Carcinoma |
Q33870379 | Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection |
Q34614798 | Detection of cyclic di-AMP using a competitive ELISA with a unique pneumococcal cyclic di-AMP binding protein |
Q26849516 | Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections |
Q37002507 | Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity |
Q35634752 | Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity |
Q38907820 | Discriminating self from non-self in nucleic acid sensing |
Q38748161 | Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice |
Q37612596 | ELF4 is critical for induction of type I interferon and the host antiviral response |
Q48215801 | ERAdP standing in the shadow of STING innate immune signaling. |
Q51346281 | Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. |
Q36340894 | Extensive evolutionary and functional diversity among mammalian AIM2-like receptors |
Q34998251 | Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1. |
Q35009130 | Glutathione activates virulence gene expression of an intracellular pathogen. |
Q38705916 | Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response |
Q41429405 | Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida |
Q90642181 | Host-Intrinsic Interferon Status in Infection and Immunity |
Q46552034 | How to rewire the host cell: A home improvement guide for intracellular bacteria. |
Q35867588 | Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT. |
Q36253264 | IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice |
Q46039774 | IRF3 and type I interferons fuel a fatal response to myocardial infarction. |
Q57080588 | IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation |
Q78177373 | IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. |
Q39899771 | Identification and expression analysis of the sting gene, a sensor of viral DNA, in common carp Cyprinus carpio. |
Q42684357 | Identification and isolation of stimulator of interferon genes (STING): an innate immune sensory and adaptor gene from camelids |
Q36157771 | Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model |
Q37982838 | Induction and function of IFNβ during viral and bacterial infection |
Q38711286 | Induction of tumor regression by intratumoral STING agonists combined with anti-programmed death-L1 blocking antibody in a preclinical squamous cell carcinoma model |
Q37997334 | Induction of type I IFNs by intracellular DNA-sensing pathways |
Q89983981 | Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis |
Q36923600 | Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion |
Q28303382 | Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses |
Q27691461 | Innate immune detection of microbial nucleic acids. |
Q27027584 | Innate immune responses to DNA viruses |
Q97418217 | Interferon-independent STING signaling promotes resistance to HSV-1 in vivo |
Q28081406 | International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease |
Q40099497 | Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells |
Q41950656 | Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS. |
Q49832539 | LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. |
Q40696672 | Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection |
Q37149925 | Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1 |
Q37601458 | Listeria monocytogenes MDR transporters are involved in LTA synthesis and triggering of innate immunity during infection. |
Q37265333 | Listeria monocytogenes and the Inflammasome: From Cytosolic Bacteriolysis to Tumor Immunotherapy |
Q39401908 | Listeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity |
Q34324531 | Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway |
Q36156009 | Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability |
Q48260251 | Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity |
Q112279597 | Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection |
Q38220292 | MITA/STING: a central and multifaceted mediator in innate immune response |
Q35175367 | MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. |
Q54487555 | MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. |
Q38125018 | Master sensors of pathogenic RNA - RIG-I like receptors |
Q36736620 | Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry |
Q92655866 | Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes |
Q38315636 | Microbial DNA recognition by cGAS-STING and other sensors in dendritic cells in inflammatory bowel diseases |
Q64106899 | Mitochondrial DNA Leakage Caused by Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells |
Q35151746 | Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway |
Q37994068 | Modulating immunity as a therapy for bacterial infections |
Q28080773 | Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer |
Q38082423 | Molecular basis of DNA recognition in the immune system |
Q34774733 | Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives |
Q34339243 | Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid |
Q35191858 | Mutations of the Listeria monocytogenes peptidoglycan N-deacetylase and O-acetylase result in enhanced lysozyme sensitivity, bacteriolysis, and hyperinduction of innate immune pathways |
Q31058151 | Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP. |
Q28975619 | NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING |
Q35836140 | Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants. |
Q34778349 | Near-infrared light responsive synthetic c-di-GMP module for optogenetic applications. |
Q38120958 | Newly described pattern recognition receptors team up against intracellular pathogens |
Q92188802 | Novel TMEM173 Mutation and the Role of Disease Modifying Alleles |
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Q38230646 | OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids |
Q40136060 | Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. |
Q37559681 | Outrunning the Red Queen: bystander activation as a means of outpacing innate immune subversion by intracellular pathogens |
Q59093291 | Parkin and PINK1 mitigate STING-induced inflammation |
Q34367481 | Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects |
Q35607012 | Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response |
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Q35343462 | RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses |
Q41360656 | RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids |
Q34709924 | RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells |
Q38752535 | RIG-I-Mediated STING Upregulation Restricts Herpes Simplex Virus 1 Infection |
Q37061815 | RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine |
Q39144454 | Rationale for stimulator of interferon genes-targeted cancer immunotherapy |
Q27025822 | Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants |
Q98949264 | Reactive oxygen species oxidize STING and suppress interferon production |
Q39360861 | Regulating STING in health and disease |
Q41908811 | Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins |
Q35783804 | Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16 |
Q36208213 | Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1. |
Q59350771 | Role of the cGAS-STING pathway in cancer development and oncotherapeutic approaches |
Q50096040 | STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis |
Q35858368 | STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade |
Q34317532 | STING and the innate immune response to nucleic acids in the cytosol |
Q50292080 | STING binds c-di-GMP |
Q24633648 | STING is a direct innate immune sensor of cyclic di-GMP |
Q66678707 | STING is required for host defense against neuropathological West Nile virus infection |
Q92664085 | STING modulators: Predictive significance in drug discovery |
Q91890877 | STING signaling and host defense against microbial infection |
Q38293111 | STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy? |
Q52714689 | STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection. |
Q38711931 | STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity |
Q36177240 | STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria. |
Q36872696 | STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. |
Q54558364 | STING-dependent signaling. |
Q35082223 | STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes |
Q39389951 | STING-mediated DNA sensing in cancer immunotherapy |
Q90609055 | STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis |
Q34326002 | STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. |
Q26776009 | STING: infection, inflammation and cancer |
Q90176744 | Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H |
Q40283395 | Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State |
Q40457768 | Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. |
Q38010664 | Sensing the messenger: the diverse ways that bacteria signal through c-di-GMP. |
Q26799867 | Sensors of Infection: Viral Nucleic Acid PRRs in Fish |
Q41621190 | Signalling strength determines proapoptotic functions of STING. |
Q21132463 | Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides |
Q27677466 | Species-specific detection of the antiviral small-molecule compound CMA by STING |
Q56349500 | Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease |
Q46189367 | Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control |
Q41735508 | Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus |
Q37041854 | Strategies Used by Bacteria to Grow in Macrophages |
Q27679046 | Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding |
Q40119109 | Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signaling complexes. |
Q40280801 | Synthetic nanovaccines for immunotherapy. |
Q36350923 | TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. |
Q64989143 | TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors. |
Q34640637 | TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria |
Q64268855 | Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines |
Q39121627 | The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele |
Q38919672 | The Complement Anaphylatoxins C5a and C3a Suppress IFN-β Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway |
Q35738682 | The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy |
Q37833954 | The Emerging Roles of STING in Bacterial Infections |
Q92645945 | The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING |
Q42164969 | The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans |
Q92702245 | The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans |
Q37925069 | The PYHIN protein family as mediators of host defenses. |
Q60050760 | The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity |
Q92571706 | The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders |
Q91999288 | The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells |
Q91069258 | The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease |
Q38275607 | The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease |
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Q33563711 | The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons |
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