The Emerging Roles of STING in Bacterial Infections

scientific article published on 15 June 2017

The Emerging Roles of STING in Bacterial Infections is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TIM.2017.05.008
P932PMC publication ID5650497
P698PubMed publication ID28625530

P50authorBernhard RyffelQ40398470
P2093author name stringSergio C Oliveira
Sulayman Benmerzoug
Fabio V Marinho
V F J Quesniaux
P2860cites workThe WHO 2014 global tuberculosis report--further to go.Q41582280
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signalingQ41851410
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilisQ42783443
Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteriaQ43596491
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and ArchaeaQ46421470
Type VII secretion--mycobacteria show the way.Q48689947
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuoleQ50083524
Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.Q50996942
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.Q52891231
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinaseQ22010870
Mitochondrial DNA stress primes the antiviral innate immune responseQ23030015
Activation of STAT6 by STING is critical for antiviral innate immunityQ24293312
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defensesQ24297790
IFI16 is an innate immune sensor for intracellular DNAQ24301720
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCQ24319706
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeQ24319799
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITAQ24321482
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathwayQ24601311
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon responseQ24616827
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMPQ24642631
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune responseQ24643548
Roles of cyclic diguanylate in the regulation of bacterial pathogenesisQ24656979
STING: infection, inflammation and cancerQ26776009
STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae SurvivalQ39758154
Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9.Q40088398
HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T CellsQ40516205
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.Q40548680
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.Q40586213
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.Q40610046
Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon ProductionQ40613531
LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific MannerQ40673144
Viruses transfer the antiviral second messenger cGAMP between cellsQ41079643
Transmission of innate immune signaling by packaging of cGAMP in viral particlesQ41079648
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosisQ41116868
Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.Q41181573
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicidaQ41429405
Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I InterferonsQ27314790
Structural mechanism of cytosolic DNA sensing by cGASQ27678393
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseasesQ28082381
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAQ28118718
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β ResponsesQ28264207
Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulenceQ28485721
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunityQ28509328
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseQ28510485
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STINGQ28545831
Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infectionQ28590924
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STINGQ28975619
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome MaturationQ29030353
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesQ29547420
Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon responseQ30009223
Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in MacrophagesQ30277329
Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.Q33592743
Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infectionQ33824328
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunityQ33830730
Identification of a Streptococcus pyogenes SF370 gene involved in production of c-di-AMP.Q33912627
Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protectionQ33916629
MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infectionQ33988738
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.Q34006614
c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stressQ34016233
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Q34084866
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotidesQ34151349
Molecular basis of group A streptococcal virulenceQ34188734
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathwayQ34259150
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophagesQ34275913
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathwayQ34324531
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGQ34346633
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.Q34419467
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infectionQ34469746
Inflammasomes as polyvalent cell death platformsQ34520989
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMPQ34550996
Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tractQ35006270
STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.Q35263440
A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.Q35328612
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate AutophagyQ35738682
Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritisQ35835759
Hyperinduction of host beta interferon by a Listeria monocytogenes strain naturally overexpressing the multidrug efflux pump MdrT.Q35867588
Modulation of the cGAS-STING DNA sensing pathway by gammaherpesvirusesQ35946145
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory DiseaseQ35956285
Group A streptococci efficiently invade human respiratory epithelial cellsQ35961517
DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiotaQ35983307
Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses SelectivelyQ35988743
The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-DependentQ36097401
Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.Q36707566
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I InterferonsQ36857386
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.Q36872696
Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJQ37044189
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.Q37055696
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.Q37353206
The Bacterial Second Messenger Cyclic di-GMP Regulates Brucella Pathogenesis and Leads to Altered Host Immune ResponseQ37424996
The ubiquitin ligase parkin mediates resistance to intracellular pathogensQ37458253
AIM2 inhibits autophagy and IFN-β production during M. bovis infectionQ37565010
Neisseria gonorrhoeae survives within and modulates apoptosis and inflammatory cytokine production of human macrophagesQ37590165
Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges.Q37655959
Type III secretion, contact-dependent model for the intracellular development of chlamydiaQ37861994
Selective autophagyQ38144281
STING-dependent cytosolic DNA sensing pathwaysQ38169005
Microbial sensing by Toll-like receptors and intracellular nucleic acid sensorsQ38258737
STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?Q38293111
The cGAS-STING Defense Pathway and Its Counteraction by VirusesQ38500828
Transcription Factor NF-κB: An Update on Intervention StrategiesQ38802627
Bacterial E3 Ubiquitin Ligase IpaH4.5 of Shigella flexneri Targets TBK1 To Dampen the Host Antibacterial ResponseQ38809321
The role of autophagy in microbial infection and immunityQ38912271
Cytosolic RNA:DNA hybrids activate the cGAS-STING axisQ38937702
The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signalingQ38949484
P921main subjectbites and stingsQ54911704
P577publication date2017-06-15
P1433published inTrends in MicrobiologyQ15265732
P1476titleThe Emerging Roles of STING in Bacterial Infections

Reverse relations

cites work (P2860)
Q64084103A venomous relationship: Inflammation, the gut barrier and the STING pathway
Q88948473Biofilm formation - what we can learn from recent developments
Q59349462Camouflage and interception: How pathogens evade detection by intracellular nucleic acid sensors
Q64066817Combined analysis and validation for DNA methylation and gene expression profiles associated with prostate cancer
Q54235242Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus.
Q64067571How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication
Q93211674Klebsiella pneumoniae infection biology: living to counteract host defences
Q91231275Mitochondria in innate immune signaling
Q91890877STING signaling and host defense against microbial infection
Q59791271STING-dependent sensing of self-DNA drives silica-induced lung inflammation
Q64092563STING-mediated intestinal barrier dysfunction contributes to lethal sepsis
Q90110242TMEM173 Drives Lethal Coagulation in Sepsis
Q89636147The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Q54201127The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection.
Q94671262The role of the adaptor molecule STING during Schistosoma mansoni infection
Q98289837cGAS-STING pathway in oncogenesis and cancer therapeutics

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