Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

scientific article

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2016.05.030
P8608Fatcat IDrelease_s6q7lkhuongibhdhuryoath5di
P932PMC publication ID5401638
P698PubMed publication ID27264171

P50authorVeit HornungQ16295222
Tobias SchmidtQ56446929
Evelyn A Kurt-JonesQ56783103
Douglas T GolenbockQ89508853
P2093author name stringScott A Shaffer
Katherine A Fitzgerald
Joseph P Dillard
Sarika Agarwal
Warrison A Andrade
Shunyan Mo
P2860cites workCrystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist EritoranQ24292781
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon responseQ24616827
STING is a direct innate immune sensor of cyclic di-GMPQ24633648
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasomeQ24655696
Strain-specific differences in Neisseria gonorrhoeae associated with the phase variable gene repertoireQ24801732
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STINGQ27678540
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAQ28118718
Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responsesQ28303382
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunityQ28509328
A bacterial siren song: intimate interactions between Neisseria and neutrophilsQ30422438
Intracellular survival of Neisseria gonorrhoeae in male urethral epithelial cells: importance of a hexaacyl lipid AQ30799516
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophagesQ31149679
Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infectionQ33824328
The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infectionQ33883413
Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protectionQ33916629
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotidesQ34151349
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophagesQ34275913
Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathwayQ34324531
The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.Q34419467
Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011-2012): genetic characteristics of isolates with reduced sensitivity to ceftriaxoneQ34677116
Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathwaysQ34690369
Biology and pathogenesis of the evolutionarily successful, obligate human bacterium Neisseria meningitidisQ34983505
The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic diseaseQ35029252
Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strainsQ35105676
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infectionQ35199121
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate AutophagyQ35738682
The Gonococcal Transcriptome during Infection of the Lower Genital Tract in Women.Q35921305
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axisQ36229527
Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteinsQ36315577
Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.Q36399581
Type IV secretion systems and their effectors in bacterial pathogenesis.Q36418304
Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds.Q36426082
Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in womenQ36594602
Iron depletion limits intracellular bacterial growth in macrophagesQ36787471
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.Q36872696
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.Q37055696
Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrheaQ37548187
Neisseria gonorrhoeae survives within and modulates apoptosis and inflammatory cytokine production of human macrophagesQ37590165
Induction of type I interferons by bacteriaQ37756215
The struggle for iron - a metal at the host-pathogen interface.Q37801985
Nucleic acid recognition by the innate immune systemQ37827142
Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophagesQ37857035
STING-dependent cytosolic DNA sensing pathwaysQ38169005
The iron efflux protein ferroportin regulates the intracellular growth of Salmonella entericaQ40290550
Iron acquisition in microbial pathogenesisQ40680046
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosisQ41116868
Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.Q41181573
XerCD-Mediated Site-Specific Recombination Leads to Loss of the 57-Kilobase Gonococcal Genetic IslandQ42165046
Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteriaQ43596491
Neisseria gonorrhoeae secretes chromosomal DNA via a novel type IV secretion systemQ48147768
The pathogenesis of gonococcal urethritis in men: confocal and immunoelectron microscopic analysis of urethral exudates from men infected with Neisseria gonorrhoeaeQ48520504
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome ActivationQ57258441
Longitudinal evaluation of serovar-specific immunity to Neisseria gonorrhoeaeQ74455345
Lymphocyte apoptosis as an immune subversion strategy of microbial pathogensQ80334944
Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophagesQ81809663
P433issue11
P921main subjectNeisseria gonorrhoeaeQ131129
toll-like receptorQ408004
P304page(s)2438-2448
P577publication date2016-06-01
P1433published inCell ReportsQ5058165
P1476titleType I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
P478volume15

Reverse relations

cites work (P2860)
Q33636066Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion
Q48018633Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
Q39195781Cytosolic nucleic acid sensors and innate immune regulation
Q54257337Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease.
Q49925707For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages.
Q60938403Macrophage- Interactions: A Better Understanding of Pathogen Mechanisms of Immunomodulation
Q47795712Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
Q92650627Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages
Q52964869Mitochondria provide a 'complex' solution to a bacterial problem.
Q64983096Mitochondria-Derived Damage-Associated Molecular Patterns in Sepsis: From Bench to Bedside.
Q95328953Molecular mechanisms and cellular functions of cGAS-STING signalling
Q58721050Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases
Q45069667Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae
Q59813480Pathogenesis of and the Host Defense in Ascending Infections of Human Fallopian Tube
Q39374120Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition.
Q38959510Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
Q92664085STING modulators: Predictive significance in drug discovery
Q37833954The Emerging Roles of STING in Bacterial Infections
Q39084591Type I Interferons in Bacterial Infections: A Balancing Act.
Q38972881cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling
Q48023186cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses

Search more.