Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.

scientific article published on 30 April 2018

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1103686011
P356DOI10.1038/S41591-018-0010-1
P932PMC publication ID6117613
P698PubMed publication ID29713085

P50authorCarl H. JuneQ19277113
Simon F LaceyQ56978267
Joseph A. FraiettaQ85544113
Irina KulikovskayaQ85544118
Minnal GuptaQ85544121
Bruce L. LevineQ85544154
F Brad JohnsonQ87970833
E. John WherryQ88954779
Jan MelenhorstQ90374440
Jun XuQ96211892
David L. PorterQ110797660
Noelle V. FreyQ110799186
Edward PequignotQ117233462
P2093author name stringYan Wang
Fang Chen
Li Liu
Jennifer L Brogdon
Hans Bitter
Sadik H Kassim
Alexander C Huang
Wei-Ting Hwang
Lifeng Tian
Regina M Young
Changfeng Zhang
Felipe Bedoya
Iulian Pruteanu-Malinici
Alina C Boesteanu
Corin Dorfmeier
David E Ambrose
Donald L Siegel
Elena J Orlando
Harit Parakandi
Megan M Davis
Mercy Gohil
Nicholas Wilcox
Roddy S O'Connor
Stefan Lundh
P2860cites workTelomere measurement by quantitative PCRQ24529938
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapyQ24596055
Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patientsQ24598792
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemiaQ24632975
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and CufflinksQ24633890
Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trialsQ27312288
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataQ27860819
A human memory T cell subset with stem cell-like propertiesQ28248395
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer CellsQ28547142
HTSeq--a Python framework to work with high-throughput sequencing dataQ29614489
STAR: ultrafast universal RNA-seq alignerQ29615052
Chimeric antigen receptor T cells for sustained remissions in leukemiaQ29617588
Natural innate and adaptive immunity to cancerQ29620313
Early immunologic correlates of HIV protection can be identified from computational analysis of complex multivariate T-cell flow cytometry assays.Q30512377
Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.Q30985619
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsQ33831940
Automated identification of stratifying signatures in cellular subpopulationsQ33854094
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemiaQ34009003
Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiationQ34028816
Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptorQ34041792
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedQ34080914
Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patientsQ34161579
Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cellsQ34480237
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systemsQ34700552
Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cellsQ34856800
Cancer immunotherapy and breaking immune tolerance: new approaches to an old challenge.Q34859794
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.Q34891171
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memoryQ35586049
Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1Q36074924
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.Q36215165
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responsesQ36229406
Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemiaQ36651344
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patientsQ36951727
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infectionQ36979967
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.Q37389018
CCR7+ selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo.Q37655544
The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.Q40050634
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trialQ40186710
Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cellsQ41259289
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemiaQ41429394
Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinibQ41601558
Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells.Q42283389
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivoQ42938990
Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potentialQ43452219
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functionsQ44443175
Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantationQ44451886
Cues-pause-point training and simultaneous communication to teach the use of signed labeling repertoires.Q50536441
Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection.Q51959814
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Q51970485
Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation.Q52184931
Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis.Q54495387
Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple CancersQ58211840
The current status of liver transplantationQ68246741
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocolQ80093221
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T CellsQ88853226
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)563-571
P577publication date2018-04-30
P1433published inNature MedicineQ1633234
P1476titleDeterminants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.
P478volume24

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cites work (P2860)
Q92407428'Off-the-shelf' allogeneic CAR T cells: development and challenges
Q9920988714-Color single tube for flow cytometric characterization of CD5+ B-LPDs and high sensitivity automated minimal residual disease quantitation of CLL/SLL
Q9786696590Y-labeled anti-CD45 antibody allogeneic hematopoietic cell transplantation for high-risk multiple myeloma
Q90413936A Bump in the Road: How the Hostile AML Microenvironment Affects CAR T Cell Therapy
Q64120024A good response of refractory mantel cell lymphoma to haploidentical CAR T cell therapy after failure of autologous CAR T cell therapy
Q100750316Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy
Q92611061Activation and expansion of human T cells using artificial antigen-presenting cell scaffolds
Q104503891Addressing patient to patient variability for autologous CAR T therapies
Q99628544Advances in CAR T-Cell Therapy for Aggressive B-NHL
Q92703407Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment
Q57053387Allogeneic CAR-T Cells: More than Ease of Access?
Q92405209An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment
Q91526765Anti-BCMA CAR T-cell therapy in multiple myeloma: can we do better?
Q58883571Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
Q90028964Are CAR T cells better than antibody or HCT therapy in B-ALL?
Q92864734At the Intersection of Biomaterials and Gene Therapy: Progress in Non-viral Delivery of Nucleic Acids
Q92522868B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma
Q104610983Best practices for the development, analytical validation and clinical implementation of flow cytometric methods for chimeric antigen receptor T cell analyses
Q95274320Biomarkers in individualized management of chimeric antigen receptor T cell therapy
Q91736550Brain immunology and immunotherapy in brain tumours
Q52385841Bringing the next Generation of Immuno-Oncology Biomarkers to the Clinic.
Q90677062CAR T Cell Therapy Progress and Challenges for Solid Tumors
Q99730742CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?
Q60047537CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success
Q64235860CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment
Q64891859CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
Q90080719CAR T and CAR NK cells in multiple myeloma: Expanding the targets
Q90990072CAR T cell therapy: inroads to response and resistance
Q92245332CAR T cells for brain tumors: Lessons learned and road ahead
Q97524803CAR T-Cell Therapy for B-Cell non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Clinical Trials and Real-World Experiences
Q98771206CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions
Q96306695CAR T-cell immunotherapy of B-cell malignancy: the story so far
Q90705235CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV
Q58572502CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge
Q64250623CAR-T with License to Kill Solid Tumors in Search of a Winning Strategy
Q92296446CD19 CAR T cell product and disease attributes predict leukemia remission durability
Q92039571CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
Q90482319CIMT 2019: report on the 17th Annual Meeting of the Association for Cancer Immunotherapy
Q90596725Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency
Q100455153Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas
Q92301970Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies
Q89895682Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies: An Update of the Pivotal Clinical Trial Data
Q59793960Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance
Q94526312Chimeric antigen receptor T cell therapy comes to clinical practice
Q90349845Chimeric antigen receptor T-cell therapies: Optimising the dose
Q100940706Chimeric antigen receptor T-cell therapy for acute lymphocytic leukaemia: where are we in 2020?
Q97424540Chimeric antigen receptor signaling: Functional consequences and design implications
Q59329883Chimeric antigen receptor-modified T cell therapy in chronic lymphocytic leukemia
Q93039099Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
Q99247595Circulation of gut-preactivated naïve CD8+ T cells enhances antitumor immunity in B cell-defective mice
Q101139022Clinical CAR-T cell and Oncolytic Virotherapy for Cancer Treatment
Q90003885Clinical lessons learned from the first leg of the CAR T cell journey
Q92563650Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy
Q64248097Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma
Q45870279Considerations in T Cell Therapy Product Development for B Cell Leukemia and Lymphoma Immunotherapy
Q64118505Current State of Immunotherapy for Treatment of Glioblastoma
Q95648221Cytokine IL-36γ improves CAR T-cell functionality and induces endogenous antitumor response
Q58700983Cytokine release syndrome: grading, modeling, and new therapy
Q92034572Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
Q99711501Decitabine-Mediated Epigenetic Reprograming Enhances Anti-leukemia Efficacy of CD123-Targeted Chimeric Antigen Receptor T-Cells
Q94503547Development of CAR-T cell therapy for B-ALL using a point-of-care approach
Q96155790Digital-Droplet PCR for Quantification of CD19-Directed CAR T-Cells
Q90007167Dissecting the tumor-immune landscape in chimeric antigen receptor T-cell therapy: key challenges and opportunities for a systems immunology approach
Q98171149Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer
Q90334543Emerging Cellular Therapies for Cancer
Q90686044Emerging strategies for combination checkpoint modulators in cancer immunotherapy
Q93103183Engaging Cytotoxic T and NK Cells for Immunotherapy in Chronic Lymphocytic Leukemia
Q90380859Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans
Q60924201Engineering and Design of Chimeric Antigen Receptors
Q91847813Engineering for Success: Approaches to Improve Chimeric Antigen Receptor T Cell Therapy for Solid Tumors
Q92059900Engineering strategies to overcome the current roadblocks in CAR T cell therapy
Q98292032Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design
Q92337122Escape From ALL-CARTaz: Leukemia Immunoediting in the Age of Chimeric Antigen Receptors
Q89457536Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma
Q92983054Evidence of long-lasting anti-CD19 activity of engrafted CD19 chimeric antigen receptor-modified T cells in a phase I study targeting pediatrics with acute lymphoblastic leukemia
Q92836860Evolution of Next Generation Therapeutics: Past, Present, and Future of Precision Medicines
Q90761903GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab
Q92283987Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges
Q90862859Genetically engineered T cells for cancer immunotherapy
Q91899225Gut microbiome and CAR-T therapy
Q98181408IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors
Q92640152IL-23 and PSMA-targeted duo-CAR T cells in Prostate Cancer Eradication in a preclinical model
Q101476400IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells
Q97597166ISSUE HIGHLIGHTS - July 2020
Q64278782Immune cells track hard-to-target brain tumours
Q64950921Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies.
Q89626900Immunotherapy of lymphomas
Q90156172Immunotherapy of multiple myeloma
Q89453284Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction
Q97530682Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen
Q93093467Improving CAR T cell immunotherapy-mediated remissions for pediatric leukemia
Q92438272In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
Q91919098Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity
Q89519257Interleukin-23 engineering improves CAR T cell function in solid tumors
Q64093637Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
Q56886922Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells
Q92480675Large-scale expansion and characterization of CD3+ T-cells in the Quantum® Cell Expansion System
Q60922704Lenalidomide can be safely combined with chlorambucil and rituximab in older patients with chronic lymphocytic leukemia
Q64998779Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy.
Q91240562L’émergence des traitements par cellules CAR-T dans les lymphomes
Q91742709Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy
Q92639482Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data
Q92150199Mechanisms of resistance to CAR T cell therapy
Q96231527Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies
Q92023481Metabolic interventions in the immune response to cancer
Q98720546Monitoring CAR T-cells using flow cytometry
Q96646541Monitoring CAR-T cell kinetics in clinical trials by multiparameteric flow cytometry: Benefits and challenges
Q100513877Monocytic Myeloid-Derived Suppressor Cells Underpin Resistance to Adoptive T Cell Therapy in Nasopharyngeal Carcinoma
Q64102615Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies
Q64268744Multiparametric analysis of CD8 T cell compartment phenotype in chronic lymphocytic leukemia reveals a signature associated with progression toward therapy
Q58548495Neurotoxicity Associated with CD19-Targeted CAR-T Cell Therapies
Q94467230New directions in chimeric antigen receptor T cell [CAR-T] therapy and related flow cytometry
Q97420808Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients
Q91826113Nitinol thin films functionalized with CAR-T cells for the treatment of solid tumours
Q60947916Oligoclonal T Cells Transiently Expand and Express Tim-3 and PD-1 Following Anti-CD19 CAR T Cell Therapy: A Case Report
Q88671244Only the best CAR T cells
Q92374995Optimization and Stability of Cell-Polymer Hybrids Obtained by "Clicking" Synthetic Polymers to Metabolically Labeled Cell Surface Glycans
Q91964127Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy
Q90690181Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia
Q92526117Peripheral Blood T-Cell Fitness Is Diminished in Patients With Pancreatic Carcinoma but Can Be Improved With Homeostatic Cytokines
Q90576088Precursor exhausted T cells: key to successful immunotherapy?
Q92480496Prevention of CAR-T-cell dysfunction
Q90453826Quantitative Control of Gene-Engineered T-Cell Activity through the Covalent Attachment of Targeting Ligands to a Universal Immune Receptor
Q100762007Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells
Q90220049Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Q90355383Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management
Q94503527Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
Q89157989STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity
Q64983614Safety and tolerability of conditioning chemotherapy followed by CD19-targeted CAR T cells for relapsed/refractory CLL.
Q91642886Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization
Q92880596Serial treatment of relapsed/refractory multiple myeloma with different BCMA-targeting therapies
Q95832157Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells
Q90855852Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic
Q93104450Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy
Q92959947Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation
Q92348600State-of-the-art for CAR T-cell therapy for chronic lymphocytic leukemia in 2019
Q92404807Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation
Q58726929Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes
Q92405303T Cell Dysfunction in Cancer Immunity and Immunotherapy
Q92245345T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance
Q90423229T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma
Q93061113TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors
Q99418746Targeting the epigenetic regulation of antitumour immunity
Q58561607Teaching an old dog new tricks: next-generation CAR T cells
Q98292030The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing
Q64075706The Discovery of Biomarkers in Cancer Immunotherapy
Q64118716The Emergence of Universal Immune Receptor T Cell Therapy for Cancer
Q92354027The Evolving Protein Engineering in the Design of Chimeric Antigen Receptor T Cells
Q57492021The Potential of CAR T Cell Therapy in Pancreatic Cancer
Q89515386The long road to the first FDA-approved gene therapy: chimeric antigen receptor T cells targeting CD19
Q90147870Trabectedin Reveals a Strategy of Immunomodulation in Chronic Lymphocytic Leukemia
Q97568608Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Q92538413Understanding and Modulating Immunity With Cell Reprogramming
Q91871527Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies
Q102369590Using single-cell analysis to predict CAR T cell outcomes
Q90262300[Combination of Oncolytic Virotherapy and CAR T/NK Cell Therapy for the Treatment of Cancer]
Q91698361c-Jun overexpression in CAR T cells induces exhaustion resistance
Q96229980convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

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