Simon F Lacey

medical researcher

Simon F Lacey is …
instance of (P31):
humanQ5

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P496ORCID iD0000-0003-2882-1962

P108employerAskBio (United States)Q30286896
University of PennsylvaniaQ49117
P734family nameLaceyQ24469938
LaceyQ24469938
LaceyQ24469938
P735given nameSimonQ4117588
SimonQ4117588
P106occupationmedical researcherQ15401884
P21sex or gendermaleQ6581097

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author (P50)
Q91189738A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor-positive cells
Q42424217A comparative study of Merkel cell, BK and JC polyomavirus infections in renal transplant recipients and healthy subjects
Q45976106A phase I study in adults of clofarabine combined with high-dose melphalan as reduced-intensity conditioning for allogeneic transplantation.
Q45946525A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.
Q61954948Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers
Q51736472Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.
Q64120245Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma
Q52579654Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.
Q35810028Assessment of cellular immunity to human cytomegalovirus in recipients of allogeneic stem cell transplants.
Q47604546Attenuated poxvirus expressing three immunodominant CMV antigens as a vaccine strategy for CMV infection.
Q38342331Attenuated poxviruses generate clinically relevant frequencies of CMV-specific T cells.
Q102056914Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals
Q92522868B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma
Q38082224Biomarkers in T-cell therapy clinical trials
Q88480236Biomarkers in chimeric antigen receptor T-cell therapy
Q60047537CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success
Q92039571CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
Q35114369CD8+ T cell-mediated suppressive activity inhibits HIV-1 after virus entry with kinetics indicating effects on virus gene expression.
Q85544183CRISPR-engineered T cells in patients with refractory cancer
Q47764871Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia
Q46690133Characterization of cytotoxic function of CMV-pp65-specific CD8+ T-lymphocytes identified by HLA tetramers in recipients and donors of stem-cell transplants
Q47622360Characterization of host immunity to cytomegalovirus pp150 (UL32).
Q35182714Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice
Q36284584Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma
Q47332598Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas
Q45878789Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer
Q29617588Chimeric antigen receptor T cells for sustained remissions in leukemia
Q41429394Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
Q35842287Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant
Q36349583Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
Q45417971Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals
Q33930455Cross-reactivity of T lymphocytes recognizing a human cytotoxic T-lymphocyte epitope within BK and JC virus VP1 polypeptides.
Q39385892Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.
Q50091857Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy: clinicopathological insights
Q46025567Cytomegalovirus immune reconstitution occurs in recipients of allogeneic hematopoietic cell transplants irrespective of detectable cytomegalovirus infection.
Q47626470DNA and low titer, helper-free, recombinant AAV prime-boost vaccination for cytomegalovirus induces an immune response to CMV-pp65 and CMV-IE1 in transgenic HLA A*0201 mice
Q97566149Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Q96223314Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
Q52715364Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.
Q39490642Development of infectious recombinant BK virus
Q100954027Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children
Q58889356Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Q88884600Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
Q30827633Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies
Q98171149Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer
Q104143710Endothelial Biomarkers Are Associated With Indirect Lung Injury in Sepsis-Associated Pediatric Acute Respiratory Distress Syndrome
Q50025585Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Q89457536Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma
Q51389717Evaluating the skin in patients undergoing chimeric antigen receptor modified T-cell therapy.
Q42645889Ex vivo detection of CD8 T cells specific for H-Y minor histocompatibility antigens in allogeneic hematopoietic stem cell transplant recipients
Q96343456First Trial of CRISPR-Edited T cells in Lung Cancer
Q45399744Functional characterization of BK virus-specific CD4+ T cells with cytotoxic potential in seropositive adults
Q33260989Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients
Q41047644Herpesvirus saimiri transformation of HIV type 1 suppressive CD8+ lymphocytes from an HIV type 1-infected asymptomatic individual
Q45736575Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8+ T cell subsets as a strong adaptive immune response to cytomegalovirus.
Q45833544IMCT-15PILOT STUDY OF T CELLS REDIRECTED TO EGFRvIII WITH A CHIMERIC ANTIGEN RECEPTOR IN PATIENTS WITH EGFRvIII+ GLIOBLASTOMA.
Q36651344Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia
Q33738328Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia
Q45710911Immunization with Th-CTL Fusion Peptide and Cytosine-Phosphate-Guanine DNA in Transgenic HLA-A2 Mice Induces Recognition of HIV-Infected T Cells and Clears Vaccinia Virus Challenge
Q37262446Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients
Q38314703In vitro expansion of polyclonal T-cell subsets for adoptive immunotherapy by recombinant modified vaccinia Ankara
Q37391085Increased programmed death-1 molecule expression in cytomegalovirus disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation
Q57059973Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Q46454296La Rosa C et al (J Infect Dis 2012; 205:1294–304).
Q91986087Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia
Q57132855Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma
Q45403250Low frequency of BK virus in prostatic adenocarcinomas
Q33851168Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy
Q34485950NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.
Q39097305Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.
Q37344283Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.
Q91279008Neurotoxicity after CTL019 in a pediatric and young adult cohort
Q41413246Noncytolytic CD8 T cell-mediated suppression of HIV replication
Q89169404Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma
Q40449697Oblimersen and alpha-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium.
Q91797314Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia
Q42363154PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.
Q37117624Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy
Q92666841Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers
Q47567558Preclinical development of an adjuvant-free peptide vaccine with activity against CMV pp65 in HLA transgenic mice.
Q45979494Programmed death-1 expression in liver transplant recipients as a prognostic indicator of cytomegalovirus disease.
Q33523611Programmed death-1 receptor and interleukin-10 in liver transplant recipients at high risk for late cytomegalovirus disease
Q34121209RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma
Q35677112Recombinant modified vaccinia virus ankara (MVA) expressing wild-type human p53 induces specific antitumor CTL expansion.
Q90374442Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells
Q47564568Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles
Q44539971Relevance of peptide avidity to the T cell receptor for cytomegalovirus-specific ex vivo CD8 T cell cytotoxicity
Q45875400Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients
Q104799444Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial
Q50026427Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
Q92880596Serial treatment of relapsed/refractory multiple myeloma with different BCMA-targeting therapies
Q46619364Simultaneous reconstitution of multiple cytomegalovirus-specific CD8+ cell populations with divergent functionality in hematopoietic stem-cell transplant recipients.
Q99356573Stable HLA antibodies following sustained CD19+ cell depletion implicate a long-lived plasma cell source
Q52016360Status of Cytomegalovirus Prevention and Treatment in 2000.
Q41918232Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor.
Q89714820Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis
Q40050634The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.
Q36576683The CXC chemokine stromal cell-derived factor 1 is not responsible for CD8+ T cell suppression of syncytia-inducing strains of HIV-1.
Q112575183The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma
Q50038368The cytological features of CAR(T) cells
Q37405194The effect of single and combined activating killer immunoglobulin-like receptor genotypes on cytomegalovirus infection and immunity after hematopoietic cell transplantation
Q96231836Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of epigenome
Q45896485Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells.
Q34742892Vaccine-induced control of viral shedding following rhesus cytomegalovirus challenge in rhesus macaques.

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