A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14.

scientific article published on 30 October 2017

A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.OPHTHA.2017.09.023
P932PMC publication ID5866166
P698PubMed publication ID29096998

P50authorZhiyong LuQ19857266
Emily ChewQ24266614
Anand SwaroopQ30506132
Rinki RatnapriyaQ83230798
Elvira AgrónQ83234331
Traci E ClemonsQ92993074
Age-Related Eye Disease Study 2 Research GroupQ117242065
P2093author name stringAyush Singhal
Michael Simmons
Freekje van Asten
Tiarnan D Keenan
P2860cites workAge-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNAQ24317658
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8Q24544001
Complement factor H polymorphism in age-related macular degenerationQ24553334
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degenerationQ24682343
Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular DegenerationQ28290149
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypesQ28943546
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factorsQ30239897
Effect of long-chain ω-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trialQ30457640
LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysisQ32125469
Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE studyQ33586908
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associationsQ33808357
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degenerationQ34066021
Natural history of drusenoid pigment epithelial detachment in age-related macular degeneration: Age-Related Eye Disease Study Report No. 28.Q34164826
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysisQ34437319
Age-related macular degeneration: genetics and biology coming togetherQ34440797
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease riskQ34452441
Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical TrialQ34490891
No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38Q34620551
The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1.Q34655539
Clinical characteristics and current treatment of age-related macular degenerationQ34930298
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study dataQ35052005
Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments TrialsQ35995626
Text mining for precision medicine: automating disease-mutation relationship extraction from biomedical literatureQ36001233
Text Mining for Precision Medicine: Bringing Structure to EHRs and Biomedical Literature to Understand Genes and HealthQ36180839
Association analysis of genetic and environmental risk factors in the cuticular drusen subtype of age-related macular degeneration.Q36194390
Text Mining Genotype-Phenotype Relationships from Biomedical Literature for Database Curation and Precision MedicineQ36207982
The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1)Q36360812
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variantsQ36556369
Retinal precursors and the development of geographic atrophy in age-related macular degeneration.Q36991543
Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2)Q36996217
ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degenerationQ37149450
Evaluation of optimized digital fundus reflex photographs for lens opacities in the age-related eye disease study 2: AREDS2 report 7Q37166967
Identification of a rare coding variant in complement 3 associated with age-related macular degenerationQ37265929
Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traitsQ37724216
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.Q38238059
Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular DegenerationQ38423796
The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degenerationQ38448712
Risk factors and biomarkers of age-related macular degenerationQ38828895
The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic targetQ39024579
The US twin study of age-related macular degeneration: relative roles of genetic and environmental influencesQ40438027
Association of LOC387715 A69S with vitreous hemorrhage in polypoidal choroidal vasculopathyQ46654633
A functional variant in the CFI gene confers a high risk of age-related macular degenerationQ47073487
Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degenerationQ48240873
Role of complement factor H I62V and age-related maculopathy susceptibility 2 A69S variants in the clinical expression of polypoidal choroidal vasculopathyQ83597754
Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean populationQ85017767
P433issue4
P921main subjectphenotypeQ104053
eye diseaseQ3041498
macular degenerationQ27429789
P304page(s)559-568
P577publication date2017-10-30
P1433published inOphthalmologyQ7098109
P1476titleA Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14.
P478volume125

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cites work (P2860)
Q92126793Application of magnetic nanoparticles in nucleic acid detection
Q92524759Association of Dietary and Supplementary Calcium Intake With Age-Related Macular Degeneration: Age-Related Eye Disease Study Report 39
Q64246936Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent
Q57826004Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Q58594328The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration

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