Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway.

scientific article published on 28 April 2011

Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIC.201100120
P698PubMed publication ID21538763

P50authorRoderich D. SüssmuthQ41669426
Tanja SchneiderQ42890232
P2093author name stringSaskia Rausch
Anne Hänchen
Alexander Denisiuk
Marius Löhken
P2860cites workFeglymycin, a novel inhibitor of the replication of the human immunodeficiency virus. Fermentation, isolation and structure elucidationQ28368368
3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteriaQ34352165
Glycopeptide and lipoglycopeptide antibioticsQ34392366
An oldie but a goodie - cell wall biosynthesis as antibiotic target pathwayQ37652425
Total synthesis of the antiviral peptide antibiotic feglymycinQ39889462
Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligaseQ42845111
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.Q43621566
Characterization and inhibition study of MurA enzyme by capillary electrophoresisQ43871900
Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).Q44522560
Antibacterial discovery and development--the failure of success?Q47825932
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
P433issue8
P304page(s)1171-1173
P577publication date2011-04-28
P1433published inChemBioChemQ634395
P1476titleFeglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway.
P478volume12

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cites work (P2860)
Q108127361A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters
Q37112508Advances in MRSA drug discovery: where are we and where do we need to be?
Q46453851Alanine scan of the peptide antibiotic feglymycin: assessment of amino acid side chains contributing to antimicrobial activity
Q52861046Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism.
Q37335513Development of a one-pot assay for screening and identification of Mur pathway inhibitors in Mycobacterium tuberculosis
Q36518393Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway
Q41826662Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation.
Q35223217UDP-N-acetylmuramic acid l-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death

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