Laminin induced local axonal translation of β-actin mRNA is impaired in SMN-deficient motoneurons

scientific article published on 19 July 2012

Laminin induced local axonal translation of β-actin mRNA is impaired in SMN-deficient motoneurons is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00418-012-0989-1
P698PubMed publication ID22810847

P50authorRobert BlumQ42172829
Michael SendtnerQ32426109
P2093author name stringSteven Havlicek
Nicolas Frank
Reena Rathod
P2860cites workAxonal elongation triggered by stimulus-induced local translation of a polarity complex proteinQ37298382
Ribosomes in axons--scrounging from the neighbors?Q37440168
To localize or not to localize: mRNA fate is in 3'UTR endsQ37588945
Subcellular mRNA localization in animal cells and why it mattersQ37645589
Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and β-Actin mRNA in Dendrites and Spines of Hippocampal NeuronsQ39648060
Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophyQ39751507
A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulumQ39881694
Gated migration: neurons migrate on but not onto substrates containing S-lamininQ41371550
The neurobiology of childhood spinal muscular atrophy.Q41489423
Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning.Q42024647
The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophyQ43569750
Dynamic visualization of local protein synthesis in hippocampal neuronsQ43631820
Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and DegradationQ43832078
Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophyQ43932877
An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidanceQ48419140
Sorting of β-Actin mRNA and Protein to Neurites and Growth Cones in CultureQ48558807
SMN, profilin IIa and plastin 3: a link between the deregulation of actin dynamics and SMA pathogenesis.Q48586391
Fragile X syndromeQ56091828
Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryosQ60215185
Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitroQ61516462
Smn depletion alters profilin II expression and leads to upregulation of the RhoA/ROCK pathway and defects in neuronal integrityQ81303651
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and functionQ24608468
In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation proteinQ28116617
Induction, assembly, maturation and maintenance of a postsynaptic apparatusQ28206352
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeQ28273791
Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneuronsQ28576647
Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2Q28591375
Distribution and Function of Laminins in the Neuromuscular System of Developing, Adult, and Mutant MiceQ28593330
Restricted Morphological and Behavioral Abnormalities following Ablation of β-Actin in the BrainQ28731512
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral VectorsQ29547596
Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1.Q30480161
Real-time visualization of ZBP1 association with beta-actin mRNA during transcription and localizationQ30717105
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytesQ33887288
The role of SMN in spinal muscular atrophy.Q33906259
Local translation of RhoA regulates growth cone collapseQ34231454
Local protein synthesis in neuronsQ34446417
Axonal Regeneration and Neuronal Function Are Preserved in Motor Neurons Lacking ß-Actin In VivoQ34708286
How and why does beta-actin mRNA target?Q35985195
Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotypeQ36234755
Neuronal RNA granules: movers and makersQ36597037
Mechanisms and cellular roles of local protein synthesis in mammalian cellsQ37123929
Function and regulation of local axonal translationQ37174970
Embryonic motor axon development in the severe SMA mouseQ37294791
P433issue5
P304page(s)737-748
P577publication date2012-07-19
P1433published inHistochemistry and Cell BiologyQ1524012
P1476titleLaminin induced local axonal translation of β-actin mRNA is impaired in SMN-deficient motoneurons
P478volume138

Reverse relations

cites work (P2860)
Q58379271A novel function for the survival motoneuron protein as a translational regulator
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Q36162571Altered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells
Q55272773Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures.
Q47150601BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221).
Q36659685Cell-autonomous axon growth of young motoneurons is triggered by a voltage-gated sodium channel
Q38546908Developing therapies for spinal muscular atrophy
Q39337972Developmental regulation of SMN expression: pathophysiological implications and perspectives for therapy development in spinal muscular atrophy
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Q38779901Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein α-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy
Q93178436Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions
Q26774987Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?
Q26996485Local translation in neuronal processes--in vivo tests of a "heretical hypothesis"
Q38134411Mechanisms for axon maintenance and plasticity in motoneurons: alterations in motoneuron disease
Q38222192Nervous translation, do you get the message? A review of mRNPs, mRNA-protein interactions and translational control within cells of the nervous system
Q43601070SMN-dependent intrinsic defects in Schwann cells in mouse models of spinal muscular atrophy
Q49808601mRNP assembly, axonal transport, and local translation in neurodegenerative diseases

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