Neurofilament Monoclonal Antibodies RT97 and 8D8 Recognize Different Modified Epitopes in Paired Helical Filament‐τ in Alzheimer's Disease

scientific article published on April 1, 1993

Neurofilament Monoclonal Antibodies RT97 and 8D8 Recognize Different Modified Epitopes in Paired Helical Filament‐τ in Alzheimer's Disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1471-4159.1993.TB03298.X
P953full work available at URLhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1471-4159.1993.tb03298.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1471-4159.1993.tb03298.x
P698PubMed publication ID7681101

P2093author name stringJ. Robertson
B. H. Anderton
J. P. Brion
A. M. Couck
T. L. Loviny
P2860cites workMonoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinantsQ48930800
Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE.Q48948134
Mapping of the Alz 50 epitope in microtubule-associated proteins tauQ49093258
Epitopes that span the tau molecule are shared with paired helical filaments.Q53186865
The carboxyl third of tau is tightly bound to paired helical filaments.Q53186869
Characterization of two pathological tau protein, variants in Alzheimer brain cortices.Q53187013
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.Q53296439
Ubiquitin is a component of paired helical filaments in Alzheimer's disease.Q53303482
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Differential sensitivity of the microtubule-associated protein, tau, in Alzheimer's disease tissue to formalin fixationQ69834370
Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and humanQ24297786
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tauQ24648590
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's diseaseQ28910345
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathologyQ29617284
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer diseaseQ29617285
Abnormal processing of multiple proteins in Alzheimer diseaseQ30450830
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer diseaseQ33582860
Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteinsQ33652987
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresisQ33720044
The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding regionQ33937669
A neuronal antigen in the brains of Alzheimer patientsQ34165422
Identification and localization of a tau peptide to paired helical filaments of Alzheimer diseaseQ34293057
Fetal-type phosphorylation of the tau in paired helical filamentsQ34377013
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brainsQ34620363
Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tanglesQ34624758
Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau proteinQ34624802
Tau protein function in living cellsQ36216609
Overexpression of tau in a nonneuronal cell induces long cellular processesQ36532768
Aberrant neurofilament phosphorylation in Alzheimer diseaseQ37692419
Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neuronsQ38342193
Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation siteQ41830652
Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylatedQ41868884
A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilitiesQ41879896
Localization of the Alz-50 epitope in recombinant human microtubule-associated protein tauQ43455343
Immunoaffinity demonstration that paired helical filaments of Alzheimer disease share epitopes with neurofilaments, MAP2 and tau.Q43857206
Phosphate-dependent monoclonal antibodies to neurofilaments and Alzheimer neurofibrillary tangles recognize a synthetic phosphopeptideQ45057702
Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractionsQ46412319
Heterogeneity of ubiquitin immunoreactivity in neurofibrillary tangles of Alzheimer's diseaseQ47796428
Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filamentsQ48272196
Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's diseaseQ48341418
One of the antigenic determinants of paired helical filaments is related to tau proteinQ48352721
Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoformsQ48571996
Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodiesQ48621838
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
monoclonal antibodyQ422248
P304page(s)1372-1382
P577publication date1993-04-01
P1433published inJournal of NeurochemistryQ6295643
P1476titleNeurofilament Monoclonal Antibodies RT97 and 8D8 Recognize Different Modified Epitopes in Paired Helical Filament‐τ in Alzheimer's Disease
P478volume60

Reverse relations

cites work (P2860)
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