| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1988PNAS...85.4506W |
| P356 | DOI | 10.1073/PNAS.85.12.4506 |
| P932 | PMC publication ID | 280459 |
| P698 | PubMed publication ID | 3132715 |
| P5875 | ResearchGate publication ID | 20023003 |
| P2093 | author name string | Walker JE | |
| Novak M | |||
| Roth M | |||
| Wischik CM | |||
| Milstein C | |||
| Jakes R | |||
| Runswick MJ | |||
| Klug A | |||
| Edwards PC | |||
| Thøgersen HC | |||
| P2860 | cites work | Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau | Q24648590 |
| Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes | Q28131700 | ||
| Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease | Q29617285 | ||
| Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels | Q33931836 | ||
| 1 Preparation of monoclonal antibodies: Strategies and procedures | Q34284111 | ||
| Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau) | Q35609568 | ||
| Immunocytochemical studies of neurofibrillary tangles. | Q35863875 | ||
| Paired helical filaments from Alzheimer disease patients contain cytoskeletal components | Q37690892 | ||
| Subunit structure of the Alzheimer tangle | Q39729351 | ||
| Use of colloidal gold particles in double-labeling immunoelectron microscopy of ultrathin frozen tissue sections | Q41356027 | ||
| Image reconstruction of the Alzheimer paired helical filament | Q41433311 | ||
| Subunit structure of paired helical filaments in Alzheimer's disease | Q41474830 | ||
| Alzheimer's paired helical filaments share epitopes with neurofilament side arms | Q42125111 | ||
| The primary structure and heterogeneity of tau protein from mouse brain | Q48122949 | ||
| Microtubule-associated protein tau. A component of Alzheimer paired helical filaments | Q48344680 | ||
| One of the antigenic determinants of paired helical filaments is related to tau protein | Q48352721 | ||
| Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants | Q48930800 | ||
| Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. | Q49074126 | ||
| ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY | Q51273858 | ||
| Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease | Q51288499 | ||
| Ubiquitin is a component of paired helical filaments in Alzheimer's disease. | Q53303482 | ||
| In vitro conditions for the self-polymerization of the microtubule-associated protein, tau factor | Q70385720 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 4506-4510 | |
| P577 | publication date | 1988-06-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease | |
| P478 | volume | 85 |
| Q38099071 | "Prion-like" templated misfolding in tauopathies |
| Q36109281 | 14-3-3ζ Mediates Tau Aggregation in Human Neuroblastoma M17 Cells |
| Q42739392 | 3R and 4R tau isoforms in paired helical filaments in Alzheimer's disease |
| Q39270980 | A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies |
| Q43494361 | A Monoclonal Antibody That Reacts Immunohistochemically with Amyloid Deposits in the Brain Tissue of Alzheimer Patients Binds to an Epitope Present on Complement Factor 4 |
| Q53310926 | A modified NOR-silver impregnation technique for amyloid plaques and neurofibrillary tangles: comparative assessment. |
| Q48435028 | A novel correlation between the levels of beta-amyloid protein precursor and tau transcripts in the aged human brain |
| Q48774769 | A novel fluorescent method for direct visualization of neurofibrillary pathology in Alzheimer's disease |
| Q33608410 | A nucleated assembly mechanism of Alzheimer paired helical filaments |
| Q33720044 | A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis |
| Q24632492 | A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions |
| Q53199877 | A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads |
| Q48687234 | A serine/threonine proline kinase activity is included in the tau protein kinase fraction forming a paired helical filament epitope |
| Q42276744 | A simple algorithm locates beta-strands in the amyloid fibril core of alpha-synuclein, Abeta, and tau using the amino acid sequence alone |
| Q48476929 | A tau-related protein of 130 kDa is present in Alzheimer brain |
| Q64245708 | A walk through tau therapeutic strategies |
| Q41879896 | A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities |
| Q33647231 | ATP-induced loss of Alz-50 immunoreactivity with the A68 proteins from Alzheimer brain is mediated by ubiquitin |
| Q90212144 | Aaron Klug and the study of Alzheimer's disease |
| Q35831092 | Aberrant accumulation of phospholipase C-delta in Alzheimer brains. |
| Q38206125 | Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target |
| Q48503134 | Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells |
| Q52238047 | Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease |
| Q48138390 | Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat |
| Q41786810 | Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease |
| Q43686152 | Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease |
| Q36426239 | Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease |
| Q48655836 | Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease |
| Q35527031 | Advanced Maillard reaction end products are associated with Alzheimer disease pathology |
| Q38870940 | Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy. |
| Q42023767 | Affinity purification of human tau proteins and the construction of a sensitive sandwich enzyme-linked immunosorbent assay for human tau detection |
| Q52146763 | Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid. |
| Q35756206 | Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines |
| Q89493910 | Altered Levels and Isoforms of Tau and Nuclear Membrane Invaginations in Huntington's Disease |
| Q40794805 | Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias |
| Q74222937 | Alzheimer disease |
| Q36433728 | Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin |
| Q49093229 | Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties |
| Q53199566 | Alzheimer paired helical filaments: a comparison with the twisted ribbon model. |
| Q40494272 | Alzheimer's Disease, ß-Amyloidosis, and Aging |
| Q36193841 | Alzheimer's disease models and functional genomics-How many needles are there in the haystack? |
| Q48262702 | Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. |
| Q53191493 | Alzheimer's disease. Paired helical filaments and the cytoskeleton. |
| Q34976291 | Alzheimer's disease: beta-Amyloid protein and tau. |
| Q37862502 | Alzheimer's disease: the challenge of the second century |
| Q48138434 | Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients |
| Q33180485 | Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice |
| Q42880381 | Amplification of Tau fibrils from minute quantities of seeds |
| Q39420600 | Amyloid precursor protein and tau transgenic models of Alzheimer‘s disease: insights from the past and directions for the future |
| Q33851064 | Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease |
| Q47715943 | Amyloidogenesis of Tau protein |
| Q53208716 | An antibody against the Alzheimer's disease amyloid precursor protein recognizes distinct conformational isoforms. |
| Q48188316 | An immunochemical study on tau glycation in paired helical filaments |
| Q42146033 | Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy |
| Q42480842 | Antisense strategy unravels tau proteins as molecular risk factors for glutamate-induced neurodegeneration. |
| Q35825892 | Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? |
| Q51263470 | Assays for the Screening and Characterization of Tau Aggregation Inhibitors. |
| Q48190781 | Assembly of Alzheimer-like filaments from full-length tau protein |
| Q48891767 | Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans |
| Q77838129 | Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease |
| Q36964038 | Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure |
| Q35796040 | Atomic force microscopy of paired helical filaments isolated from the autopsied brains of patients with Alzheimer's disease and immunolabeled against microtubule-associated protein tau |
| Q47145684 | Atypical, non-standard functions of the microtubule associated Tau protein |
| Q48291859 | Beta-amyloid protein precursor and tau mRNA levels versus beta-amyloid plaque and neurofibrillary tangles in the aged human brain |
| Q37407141 | Beyond the rat models of human neurodegenerative disorders |
| Q42672221 | Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects |
| Q35833178 | Biochemical and anatomical redistribution of tau protein in Alzheimer's disease |
| Q36465091 | Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau |
| Q44721394 | Brain ubiquitin is markedly elevated in Alzheimer disease |
| Q47108443 | Brainstem tau pathology in Alzheimer's disease is characterized by increase of three repeat tau and independent of amyloid β. |
| Q46858641 | C-terminal truncation modulates both nucleation and extension phases of tau fibrillization |
| Q33658107 | Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease |
| Q71814389 | Calpain‐Induced Proteolysis of Normal Human Tau and Tau Associated with Paired Helical Filaments |
| Q35688036 | Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain |
| Q41144848 | Catastrophe, chaos and Alzheimer's disease. The F E Williams Lecture |
| Q35934211 | Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases |
| Q38901388 | Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease |
| Q38693201 | Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models |
| Q48281702 | Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments |
| Q73134030 | Characterization of microtubule-associated proteins in teleosts |
| Q24300015 | Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain |
| Q30829185 | Co-expression of truncated and full-length tau induces severe neurotoxicity |
| Q41996773 | Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. |
| Q48838383 | Competitive ELISA for the measurement of tau protein in Alzheimer's disease |
| Q22242287 | Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease |
| Q42114209 | Conformational diversity of wild-type Tau fibrils specified by templated conformation change |
| Q48715961 | Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration |
| Q35922551 | Cross-seeding and conformational selection between three- and four-repeat human Tau proteins |
| Q41597304 | Cryo-EM structures of tau filaments from Alzheimer's disease. |
| Q41157300 | Crystallization and preliminary X-ray diffraction analysis of two peptides from Alzheimer PHF in complex with the MN423 antibody Fab fragment. |
| Q47687738 | Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro |
| Q48270156 | Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. |
| Q48330208 | Dentatorubral-pallidoluysian atrophy (DRPLA) with a small ganglioglioma component containing neurofibrillary tangles and polyglutamine aggregation. |
| Q52209534 | Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. |
| Q46127208 | Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau |
| Q52221315 | Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease. |
| Q37542016 | Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51 |
| Q33593817 | Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease |
| Q30412009 | Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration |
| Q48253639 | Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease |
| Q24564815 | Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease |
| Q41904960 | Distinct tau prion strains propagate in cells and mice and define different tauopathies |
| Q45050796 | Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. |
| Q51819282 | Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation. |
| Q35558517 | Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models |
| Q37511619 | Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial. |
| Q33830634 | Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain |
| Q35782389 | Evidence of neuronal oxidative damage in Alzheimer's disease. |
| Q38515389 | Exploring the structure and formation mechanism of amyloid fibrils by Raman spectroscopy: a review |
| Q33254317 | Expression in cultured human neuroblastoma cells of epitopes associated with affected neurons in Alzheimer's disease |
| Q41236012 | Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization |
| Q58455503 | Expression of three- and four-repeat tau isoforms in mouse liver |
| Q53182764 | Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia. |
| Q42836387 | FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions |
| Q42049177 | Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy |
| Q34377013 | Fetal-type phosphorylation of the tau in paired helical filaments |
| Q42065690 | Fibers of tau fragments, but not full length tau, exhibit a cross beta-structure: implications for the formation of paired helical filaments |
| Q37349941 | Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy |
| Q33703950 | Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies |
| Q47344070 | Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423. |
| Q37066038 | Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations |
| Q35764771 | Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. |
| Q37987142 | Frontotemporal dementia: implications for understanding Alzheimer disease |
| Q26777247 | Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutations |
| Q48314402 | Functional domains on chemically modified tau protein |
| Q32173558 | Glial contributions to neurodegeneration in tauopathies |
| Q47232991 | Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity |
| Q34094582 | Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability |
| Q30940142 | Hydration water mobility is enhanced around tau amyloid fibers |
| Q53119677 | Hypothalamic hamartoma with neurofibrillary tangles. |
| Q34314365 | Hypothesis: microtubules, a key to Alzheimer disease |
| Q34293057 | Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease |
| Q41082322 | Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease |
| Q41310684 | Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. |
| Q73571587 | Identification of microtubule-associated protein tau isoforms in Alzheimer's paired helical filaments |
| Q24681982 | Identification of septins in neurofibrillary tangles in Alzheimer's disease |
| Q35831902 | Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles |
| Q36703367 | Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain. |
| Q53210685 | Immunogold labelling of paired helical filaments and amyloid fibrils by specific monoclonal and polyclonal antibodies. |
| Q48790501 | Immunological characterization of epitopes on tau of Alzheimer's type and chemically modified tau. |
| Q41186950 | Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity |
| Q48599521 | In vitro assembly of Alzheimer-like filaments. How a small cluster of charged residues in Tau and MAP2 controls filament morphology |
| Q53215351 | In vitro polymerization of embryonic MAP-2c and fragments of the MAP-2 microtubule binding region into structures resembling paired helical filaments. |
| Q42051931 | Induction of epitopes associated with neurofibrillary tangles in clonal mouse neuroblastoma (S20Y) cells |
| Q92990787 | Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies |
| Q53685113 | Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review. |
| Q38515285 | Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration. |
| Q36508892 | Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis |
| Q34460089 | Introducing transglutaminase into the study of Alzheimer's disease. A personal look back |
| Q27020981 | Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging |
| Q37669514 | Is supramolecular filament chirality the underlying cause of major morphology differences in amyloid fibrils? |
| Q37514577 | Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis |
| Q41614205 | Life and death of neurons in the aging brain |
| Q36904846 | Looking for novel ways to treat the hallmarks of Alzheimer's disease |
| Q37454199 | Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322. |
| Q34938739 | Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity. |
| Q91451090 | MAPT mutations, tauopathy, and mechanisms of neurodegeneration |
| Q66680387 | Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors |
| Q37542021 | Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease. |
| Q37614978 | Mechanism of Alzheimer's disease: arguments for a neurotransmitter-aluminium complex implication |
| Q89855151 | Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model |
| Q46086091 | Memantine prevents sensitivity to excitotoxic cell death of rat cortical neurons expressing human truncated tau protein. |
| Q42911754 | Microglia display modest phagocytic capacity for extracellular tau oligomers |
| Q38713424 | Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer's Disease |
| Q24313123 | Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262 |
| Q48332575 | Microtubule-associated proteins tau and amyloid P component in Alzheimer's disease |
| Q40907496 | Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions |
| Q47308968 | Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development |
| Q26748105 | Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation |
| Q35811579 | Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study |
| Q40871850 | Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament |
| Q24555663 | Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease |
| Q37812055 | Molecular neuropathology of Alzheimer's disease: in situ hybridization studies |
| Q36976394 | Molecular pathology of Alzheimer's disease. |
| Q37658077 | Molecular structure and function of microtubule-associated proteins |
| Q42484574 | Monitoring pathological assembly of tau and beta-amyloid proteins in Alzheimer's disease |
| Q42141099 | Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes |
| Q33559556 | Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis |
| Q50101026 | Neurodegeneration and the ordered assembly of α-synuclein |
| Q36477014 | Neurofibrillary Tangles, Dystrophic IMeurites (Curly Fibers), and Abnormal Phosphorylation of Tau |
| Q42050682 | Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease |
| Q72971650 | Neurofibrillary tangles in the neurons of spinal dorsal root ganglia of patients with progressive supranuclear palsy |
| Q53201554 | Neurofilament Monoclonal Antibodies RT97 and 8D8 Recognize Different Modified Epitopes in Paired Helical Filament‐τ in Alzheimer's Disease |
| Q41263650 | Neuronal Cdc2-like kinase: from cell cycle to neuronal function |
| Q50990954 | Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis. |
| Q37793507 | Neuronal responses to injury and aging: lessons from animal models |
| Q42873156 | Neuron‐selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: Essential role for aggregation in neurotoxicity |
| Q28775941 | Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease |
| Q26750922 | New Features about Tau Function and Dysfunction |
| Q37395885 | New age of neuroproteomics in Alzheimer's disease research |
| Q34156138 | New insights into genetic and molecular mechanisms of brain degeneration in tauopathies |
| Q48465841 | New patterns of intraneuronal accumulation of the microtubular binding domain of tau in granulovacuolar degeneration |
| Q47896160 | Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series |
| Q37189443 | Non-targeted identification of prions and amyloid-forming proteins from yeast and mammalian cells |
| Q41727024 | Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. |
| Q26769950 | Nuclear Tau and Its Potential Role in Alzheimer's Disease |
| Q57986225 | Oligomer Diversity during the Aggregation of the Repeat Region of Tau |
| Q77384408 | Oral and subcutaneous administration of the glycosaminoglycan C3 attenuates Abeta(25-35)-induced abnormal tau protein immunoreactivity in rat brain |
| Q42855049 | Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease |
| Q33983175 | Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments |
| Q48033282 | PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. |
| Q35058484 | PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo |
| Q53186077 | Paired helical filaments are not the major binding sites for wheat germ and Dolichos biflorus agglutinins in the neurofibrillary tangles of Alzheimer's disease. |
| Q84590188 | Pathogenesis of the tauopathies |
| Q48389127 | Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies |
| Q53184505 | Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins. |
| Q30613304 | Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. |
| Q45057702 | Phosphate-dependent monoclonal antibodies to neurofilaments and Alzheimer neurofibrillary tangles recognize a synthetic phosphopeptide |
| Q24292882 | Phosphorylation of microtubule-associated protein tau by AMPK-related kinases |
| Q93037794 | Phosphorylation of serine 305 in tau inhibits aggregation |
| Q48395304 | Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments |
| Q33861704 | Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders |
| Q71823486 | Polymerization of Microtubule-associated Protein Tau under Near-physiological Conditions |
| Q74664401 | Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations |
| Q42519015 | Post-aggregation oxidation of mutant huntingtin controls the interactions between aggregates. |
| Q37573270 | Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau's interaction with microtubules in axon-like processes. |
| Q64898725 | Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody. |
| Q39307688 | Prion-like Spreading in Tauopathies |
| Q38248883 | Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies |
| Q38336025 | Prions and Protein Assemblies that Convey Biological Information in Health and Disease. |
| Q40750866 | Probing modifications of the neuronal cytoskeleton |
| Q68380544 | Production of a bi-specific monoclonal antibody recognizing mouse kappa light chains and horseradish peroxidase. Applications in immunoassays |
| Q53203171 | Proline-directed and non-proline-directed phosphorylation of PHF-tau. |
| Q39338832 | Propagation of Tau aggregates |
| Q44380124 | Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain |
| Q44324475 | Protective effect of the heparin-derived oligosaccharide C3, on AF64A-induced cholinergic lesion in rats |
| Q48879570 | Protein TAU variants present in paired helical filaments (PHFs) of Alzheimer brains |
| Q38214594 | Protein phosphorylation in neurodegeneration: friend or foe? |
| Q38091670 | Protein truncation as a common denominator of human neurodegenerative foldopathies |
| Q37135431 | Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD. |
| Q41896600 | Pseudohyperphosphorylation causing AD-like changes in tau has significant effects on its polymerization |
| Q42714320 | Psychiatry and neuropathology: the maturing of a relationship |
| Q53185661 | Purification and solubilization of paired helical filaments from Alzheimer brains. |
| Q53300564 | Pyramidal cell topography of microtubule-associated proteins and their precipitation into paired helical filaments. |
| Q35059268 | Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects |
| Q49247951 | RCAN1 in the inverse association between Alzheimer's disease and cancer |
| Q42422246 | RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth |
| Q34737245 | RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments |
| Q37117419 | Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice |
| Q49310065 | Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease |
| Q53374246 | Regions of tau implicated in the paired helical fragment core as defined by NMR. |
| Q35811267 | Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles |
| Q50227554 | Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease |
| Q57825213 | Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes |
| Q42049334 | Role of glycosaminoglycans in determining the helicity of paired helical filaments |
| Q48905569 | Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial |
| Q35613197 | Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation |
| Q35153833 | Selective expression of epitopes in multiphosphorylation repeats of the high and middle molecular weight neurofilament proteins in Alzheimer neurofibrillary tangles |
| Q24598853 | Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines |
| Q35830851 | Sequestration of tau by granulovacuolar degeneration in Alzheimer's disease |
| Q46688752 | Side chain-dependent stacking modulates tau filament structure |
| Q33852825 | Single mutations in tau modulate the populations of fibril conformers through seed selection |
| Q41217536 | Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A. |
| Q42110850 | Site-specific dynamic nuclear polarization of hydration water as a generally applicable approach to monitor protein aggregation |
| Q47926474 | Small-molecule PET Tracers for Imaging Proteinopathies |
| Q104064633 | Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils |
| Q48590331 | Specific monoclonal antibodies against normal microtubule-associated protein-2 (MAP2) epitopes present in Alzheimer pathological structures do not recognize paired helical filaments |
| Q35745700 | Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease |
| Q37435073 | Straight and paired helical filaments in Alzheimer disease have a common structural unit |
| Q47758213 | Structural and kinetic features of amyloid beta-protein fibrillogenesis |
| Q33586330 | Structural characterization of the core of the paired helical filament of Alzheimer disease |
| Q36817219 | Structural principles of tau and the paired helical filaments of Alzheimer's disease |
| Q34280787 | Structure and pathology of tau protein in Alzheimer disease |
| Q33971326 | Structure of tau protein and assembly into paired helical filaments |
| Q34443878 | Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases |
| Q37533492 | Surface characterization of insulin protofilaments and fibril polymorphs using tip-enhanced Raman spectroscopy (TERS). |
| Q64236054 | Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges |
| Q50350781 | Tau Filaments and the Development of Positron Emission Tomography Tracers. |
| Q26769957 | Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies |
| Q48040565 | Tau Proteins Cross the Blood-Brain Barrier |
| Q22242304 | Tau Proteins and Neurofibrillary Degeneration |
| Q34995112 | Tau and axonopathy in neurodegenerative disorders |
| Q38472413 | Tau and neurodegenerative disorders |
| Q36970350 | Tau as a therapeutic target in neurodegenerative disease |
| Q35747827 | Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau. |
| Q24312948 | Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis |
| Q35199848 | Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains |
| Q73471049 | Tau dephosphorylation at tau-1 site correlates with its association to cell membrane |
| Q57051159 | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold |
| Q34730572 | Tau function and dysfunction in neurons: its role in neurodegenerative disorders |
| Q41830652 | Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site |
| Q41868884 | Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated |
| Q55421746 | Tau in neurodegenerative disease. |
| Q38657468 | Tau in physiology and pathology |
| Q33909959 | Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease |
| Q38107632 | Tau pathology and neurodegeneration |
| Q41945501 | Tau pathology: predictive diagnostics, targeted preventive and personalized medicine and application of advanced research in medical practice |
| Q36418199 | Tau phosphorylation and aggregation in Alzheimer's disease pathology |
| Q28070250 | Tau physiology and pathomechanisms in frontotemporal lobar degeneration |
| Q37515094 | Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells |
| Q53232645 | Tau protein and the paired helical filament of Alzheimer's disease. |
| Q41836559 | Tau protein assembles into isoform- and disulfide-dependent polymorphic fibrils with distinct structural properties. |
| Q24323891 | Tau protein binds to microtubules through a flexible array of distributed weak sites |
| Q53313203 | Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain. |
| Q37812393 | Tau protein: an update on structure and function |
| Q41261728 | Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type |
| Q26739412 | Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease |
| Q22252512 | Tau-aggregation inhibitor therapy for Alzheimer's disease |
| Q50632272 | Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy. |
| Q38715233 | Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium |
| Q28831067 | Tau-mediated synaptic damage in Alzheimer's disease |
| Q93203071 | Tauopathy and neurodegeneration: A role for stress |
| Q42407159 | Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate |
| Q36642455 | Tauopathy: an overview |
| Q36671491 | Template-assisted filament growth by parallel stacking of tau. |
| Q59137449 | Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead |
| Q53384769 | The "jaws" of the tau-microtubule interaction. |
| Q37055497 | The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective |
| Q93164519 | The Cytoskeleton as a Modulator of Aging and Neurodegeneration |
| Q58246789 | The C‐terminal region of human tau protein with ability of filament formation |
| Q40990185 | The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells. |
| Q39084544 | The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of Dementia |
| Q37693375 | The Synucleinopathies: Twenty Years On. |
| Q51918243 | The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease. |
| Q38231789 | The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease |
| Q46351285 | The effect of apolipoprotein E genotype on biochemical markers of Alzheimer's disease |
| Q63101708 | The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? |
| Q44853344 | The formation of straight and twisted filaments from short tau peptides |
| Q28540122 | The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles |
| Q43897145 | The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity |
| Q36255194 | The link between cholesterol and Alzheimer's disease |
| Q43423232 | The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease |
| Q40794800 | The molecular and cellular biology of tau. |
| Q28610657 | The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis |
| Q92374124 | The neuropathological diagnosis of Alzheimer's disease |
| Q35071628 | The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease |
| Q35209677 | The repeat region of microtubule-associated protein tau forms part of the core of the paired helical filament of Alzheimer's disease |
| Q34777685 | The role of tau in Alzheimer's disease |
| Q37765632 | The role of tau in Alzheimer's disease and related disorders |
| Q46669000 | The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties |
| Q92480817 | Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans |
| Q33593147 | Three repeat isoforms of tau inhibit assembly of four repeat tau filaments |
| Q41713209 | Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease |
| Q33881855 | Tissue transglutaminase: a possible role in neurodegenerative diseases |
| Q33594005 | Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease |
| Q38027940 | Towards understanding the phosphorylation code of tau. |
| Q35921110 | Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology |
| Q48510520 | Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. |
| Q36749585 | Twisted ribbon structure of paired helical filaments revealed by atomic force microscopy |
| Q38950512 | UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review |
| Q48897393 | Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease |
| Q38234883 | Ubiquitin pathways in neurodegenerative disease |
| Q36723776 | Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease |
| Q58216336 | Ultrastructural and biochemical basis of Alzheimer's disease |
| Q37426445 | Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles |
| Q44188274 | Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques |
| Q99711176 | Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches |
| Q40833020 | Vertical Pt-C replication for TEM, a revolution in imaging non-periodic macromolecules, biological gels and low-density polymer networks |
| Q26830542 | Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways |
| Q27649220 | X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease |
| Q42127900 | beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease |
| Q48264016 | p44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons |
| Q34088124 | pH-dependent structural transitions of Alzheimer amyloid peptides |
| Q40468759 | β‐Amyloid precursor protein is modified with O‐linked N‐acetylglucosamine |
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