Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin

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Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1993PNAS...90.6825S
P356DOI10.1073/PNAS.90.14.6825
P932PMC publication ID47025
P698PubMed publication ID8393578
P5875ResearchGate publication ID14804885

P50authorJohn Q. TrojanowskiQ6253636
P2093author name stringShin RW
Lee VM
Bramblett GT
P2860cites workExpression patterns of beta-amyloid precursor protein (beta-APP) in neural and nonneural human tissues from Alzheimer's disease and control subjectsQ44975029
Amyloid beta-protein deposition in tissues other than brain in Alzheimer's diseaseQ45039020
Ubiquitin-protein conjugates in Alzheimer's lesionsQ46858168
Phosphorylation determines two distinct species of Tau in the central nervous systemQ48261881
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)Q48532140
Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoformsQ48571996
Neurofilament reassembly in vitro: biochemical, morphological and immuno-electron microscopic studies employing monoclonal antibodies to defined epitopesQ48672153
Immunological and conformation characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's diseaseQ53179342
Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease.Q53180787
Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.Q53186541
The carboxyl third of tau is tightly bound to paired helical filaments.Q53186869
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.Q53296439
Ubiquitin is a component of paired helical filaments in Alzheimer's disease.Q53303482
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tauQ67894826
The potential of the immunogold-silver staining method for paraffin sectionsQ72381507
The distribution of tau in the mammalian central nervous systemQ29622896
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer diseaseQ33582860
Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer diseaseQ33594005
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresisQ33720044
A neuronal antigen in the brains of Alzheimer patientsQ34165422
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluidsQ34255552
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brainsQ34620363
Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues.Q34888210
The disordered neuronal cytoskeleton in Alzheimer's diseaseQ35469472
Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical studyQ35811579
Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's diseaseQ35831408
Alzheimer's disease: a cell biological perspectiveQ36129542
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's diseaseQ36443496
Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.Q37721348
Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementiasQ40794805
Production of the Alzheimer amyloid beta protein by normal proteolytic processingQ41599298
Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's diseaseQ41644400
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's diseaseQ41883825
Epitopes located in spatially separate domains of each neurofilament subunit are present in parkinson's disease lewy bodiesQ41930639
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementiaQ42050538
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)6825-6828
P577publication date1993-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAlzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin
P478volume90

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cites work (P2860)
Q34530632A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer's disease
Q40494272Alzheimer's Disease, ß-Amyloidosis, and Aging
Q53246225Alzheimer's and Parkinson's disease--overlapping or synergistic pathologies?
Q48617231Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain
Q48123614An extensive network of PHF tau-rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease
Q35764636Beta-amyloid protein-containing inclusions in skeletal muscle of apolipoprotein-E-deficient mice
Q35763640Carboxyl-terminal fragments of beta-amyloid precursor protein bind to microtubules and the associated protein tau
Q42048866Interaction of aluminum with PHFtau in Alzheimer's disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method
Q40986730Mechanisms of neuronal degeneration in Alzheimer's disease
Q35763660Monoclonal antibodies to a 100-kd protein reveal abundant A beta-negative plaques throughout gray matter of Alzheimer's disease brains
Q38960046Potential mechanisms and implications for the formation of tau oligomeric strains
Q40750866Probing modifications of the neuronal cytoskeleton
Q53200544Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.
Q41370400The ubiquitin system: a role in disease?
Q37550818Therapeutic strategies for tau mediated neurodegeneration
Q42127900beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease
Q42481537β-Amyloid Peptide and Amyloid Precursor Proteins in Olfactory Mucosa of Patients with Alzheimer's Disease, Parkinson's Disease, and down Syndrome

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