Genetics and epigenetics of Parkinson's disease.

scientific article

Genetics and epigenetics of Parkinson's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1100/2012/489830
P932PMC publication ID3353471
P698PubMed publication ID22623900
P5875ResearchGate publication ID225059551

P2093author name stringFabio Coppedè
P2860cites workImportance of low-range CAG expansion and CAA interruption in SCA2 ParkinsonismQ46960409
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Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonismQ48395727
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patientsQ48489167
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brainQ48521070
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A two-stage meta-analysis identifies several new loci for Parkinson's diseaseQ21144948
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateQ22252904
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repressionQ24293587
Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicityQ24301946
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
Aging-associated alteration of subtelomeric methylation in Parkinson's disease.Q53390945
Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brainQ56637599
Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson DiseaseQ57977634
Novel mutations in SPG11 cause hereditary spastic paraplegia associated with early-onset levodopa-responsive ParkinsonismQ59153436
MicroRNA and proteome expression profiling in early-symptomatic α-synuclein(A30P)-transgenic miceQ82775800
HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced stressQ83206996
Increased incidence of Parkinson disease among relatives of patients with Gaucher diseaseQ83228051
Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusionsQ83339692
MicroRNAs in Parkinson's diseaseQ83371481
Identification of blood microRNAs associated to Parkinsonĭs diseaseQ83372764
Study of methylation levels of parkin gene promoter in Parkinson's disease patientsQ84333501
Global DNA hypomethylation and DNA hypermethylation of the alpha synuclein promoter in females with anorexia nervosaQ95790350
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationQ24312713
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36.Q24535854
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseQ24596763
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studiesQ24606055
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153Q24633965
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.Q24634577
Genome-wide association study reveals genetic risk underlying Parkinson's diseaseQ24646654
Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson diseaseQ24656075
Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36Q24680678
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
alpha-Synuclein locus triplication causes Parkinson's diseaseQ27860533
GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activationQ28116164
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPaseQ28116395
The complex language of chromatin regulation during transcriptionQ28131748
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathologyQ28131833
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's diseaseQ28257086
Aggresome formation and neurodegenerative diseases: therapeutic implicationsQ28265926
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's diseaseQ28292932
FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndromeQ28302099
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's diseaseQ28307422
alpha-Synuclein produces a long-lasting increase in neurotransmitter releaseQ28510893
A MicroRNA feedback circuit in midbrain dopamine neuronsQ28513149
α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activityQ28572683
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine systemQ28594502
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene databaseQ29417106
Repression of alpha-synuclein expression and toxicity by microRNA-7.Q29542272
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementiaQ29547174
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's diseaseQ29547175
Alpha-synuclein locus duplication as a cause of familial Parkinson's diseaseQ29614762
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's diseaseQ29614900
The PINK1/Parkin pathway regulates mitochondrial morphologyQ29615641
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in DrosophilaQ29617091
Genomewide association study for susceptibility genes contributing to familial Parkinson diseaseQ30437480
POLG1-related and other "mitochondrial Parkinsonisms": an overview.Q37827400
Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph diseaseQ37899333
Genetic mutations and functions of PINK1.Q37904442
Identification of gene expression changes in transgenic C. elegans overexpressing human alpha-synucleinQ38518569
MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial functionQ39545068
Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibitionQ39676713
Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease.Q39722408
Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repairQ39823278
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.Q39955983
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinomaQ39979336
Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in AsiaQ40251831
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.Q40503405
Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's diseaseQ42628290
Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutationsQ42947297
DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein functionQ43073853
Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease modelsQ43187683
Methylation status and neurodegenerative markers in Parkinson diseaseQ43292322
Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study.Q43861801
Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?Q44479792
The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese familyQ44984888
DNA hypermethylation of the alpha synuclein promoter in patients with alcoholismQ45239060
Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.Q45922508
Nuclear localization of alpha-synuclein and its interaction with histonesQ46597702
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Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's diseaseQ30493604
Replication of MAPT and SNCA, but not PARK16-18, as susceptibility genes for Parkinson's disease.Q30499875
Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's diseaseQ33323265
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's diseaseQ33760744
Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegenerationQ33762517
Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formationQ33948478
One-carbon metabolism and Alzheimer's disease: focus on epigeneticsQ34094250
FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients.Q34115520
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityQ34157005
Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 proteinQ34197130
Parkin genetics: one model for Parkinson's diseaseQ34300017
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagyQ34399382
Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemiaQ34467458
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.Q34660005
Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseasesQ34685028
Molecular insights into Parkinson's diseaseQ34988753
Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's diseaseQ35385117
Epigenetic mechanisms in developmental programming of adult disease.Q35581063
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damageQ35708210
Advances in epigenetics and epigenomics for neurodegenerative diseasesQ35709124
Exploring the link between glucocerebrosidase mutations and parkinsonismQ35955350
Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degenerationQ36123405
The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disordersQ36486264
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synucleinQ36718966
Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arraysQ36719174
Biomarkers of folate and vitamin B(12) status in cerebrospinal fluidQ36950520
Spinocerebellar ataxia 2 (SCA2).Q37140787
Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseasesQ37332243
Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c releaseQ37397403
Histone deacetylases as targets for the treatment of human neurodegenerative diseasesQ37602632
Epigenetic regulation in the pathophysiology of Alzheimer's diseaseQ37680418
Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutationsQ37776461
Epigenetics in neurodegeneration: a new layer of complexity.Q37782161
Genetic Analysis of Pathways to Parkinson DiseaseQ37801078
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
P304page(s)489830
P577publication date2012-05-01
P1433published inThe Scientific World JournalQ7762585
P1476titleGenetics and epigenetics of Parkinson's disease.
P478volume2012

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