The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes.

scientific article published on 12 January 2007

The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M607712200
P698PubMed publication ID17220301

P2093author name stringTushar Patel
Heather Smith
Yoshiyuki Ueno
Fanyin Meng
Hania Wehbe-Janek
Roger Henson
P2860cites workNeurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signalingQ24319849
RAS is regulated by the let-7 microRNA familyQ27860522
Unique microRNA molecular profiles in lung cancer diagnosis and prognosisQ27860631
A microRNA polycistron as a potential human oncogeneQ27860720
Oncomirs - microRNAs with a role in cancerQ27860773
c-Myc-regulated microRNAs modulate E2F1 expressionQ27861046
MicroRNA expression profiles classify human cancersQ28032481
let-7 microRNA functions as a potential growth suppressor in human colon cancer cellsQ28237683
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cellsQ28262214
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survivalQ28264400
Specificity of microRNA target selection in translational repressionQ28776123
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell linesQ28975767
The colorectal microRNAomeQ29616082
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptorsQ33941380
Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytesQ34881846
The role of IL-6 and STAT3 in inflammation and cancerQ36274467
Prediction and validation of microRNAs and their targetsQ36281297
Gene regulation by microRNAsQ36406938
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesisQ37486563
Evaluation of potential Stat3-regulated genes in human breast cancerQ38322580
Membrane-associated STAT3 and PY-STAT3 in the cytoplasm.Q40331313
Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cellsQ40345898
Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosisQ40832782
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cellsQ40972355
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
microRNAQ310899
P304page(s)8256-8264
P577publication date2007-01-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes.
P478volume282

Reverse relations

cites work (P2860)
Q35562369A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma.
Q36411472A six-microRNA set as prognostic indicators for bile duct cancer
Q37878880Aberrant DNA methylation profile in cholangiocarcinoma
Q39881903Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1.
Q35655840Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis
Q38228503Autophagy and microRNA dysregulation in liver diseases
Q35953283Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile
Q36250109Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Q36130078Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma
Q36406800Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer
Q45883493Decreased expression of microRNA-375 in nonsmall cell lung cancer and its clinical significance
Q37275739Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin
Q35191416Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein
Q37798161Desperately seeking microRNA targets
Q36224976Downregulation of microRNA‑33a promotes cyclin‑dependent kinase 6, cyclin D1 and PIM1 expression and gastric cancer cell proliferation
Q39318958Dynamic regulation of microRNA expression following interferon-γ-induced gene transcription.
Q34200081Emerging insights into the role of microRNAs in the pathogenesis of cholangiocarcinoma
Q38642455Emerging molecular targets and therapy for cholangiocarcinoma
Q24624514Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7
Q37306838Epigenetic modifications in rheumatoid arthritis
Q46608275Epigenetic role of miRNAs in normal and leukemic hematopoiesis
Q35048239Functional analysis of microRNAs in human hepatocellular cancer stem cells
Q37045820Genetic and epigenetic changes associated with cholangiocarcinoma: from DNA methylation to microRNAs
Q27005787Genetic profiling of intrahepatic cholangiocarcinoma
Q34412371Genomic DNA copy-number alterations of the let-7 family in human cancers
Q36051517High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease
Q33889122IL-6R/STAT3/miR-204 feedback loop contributes to cisplatin resistance of epithelial ovarian cancer cells
Q34838128Identification of miRNAs associated with tumorigenesis of retinoblastoma by miRNA microarray analysis
Q28394212Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of rapamycin complex 1 regulation and global protein translation
Q33372109Interfering RNA and HIV: reciprocal interferences
Q36938072Interleukin-6 and its receptor in cancer: implications for translational therapeutics
Q34399321Lactation-related microRNA expression profiles of porcine breast milk exosomes
Q39789168Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells
Q37640216Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk
Q36955306Lin28 and let-7: roles and regulation in liver diseases.
Q34428326Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion
Q58704736Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells
Q44139838MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma
Q37238372MiRNAs, epigenetics, and cancer
Q37751868MicroRNA and drug resistance
Q33926927MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes
Q39015995MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint.
Q28510366MicroRNA expression and regulation in mouse uterus during embryo implantation
Q39580400MicroRNA expression in tumor cells from Waldenstrom's macroglobulinemia reflects both their normal and malignant cell counterparts.
Q81345831MicroRNA expression profiling: a molecular tool for defining the phenotype of hepatocellular tumors
Q85541574MicroRNA let-7a ameliorates con A-induced hepatitis by inhibiting IL-6-dependent Th17 cell differentiation
Q37388413MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer
Q28475999MicroRNA signature and regulatory functions in the endometrium during normal and disease states
Q38509951MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications
Q27488310MicroRNA signatures in liver diseases
Q34895116MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b.
Q34228326MicroRNA-22 can reduce parathymosin expression in transdifferentiated hepatocytes
Q35601698MicroRNA-let-7a expression is increased in the mesangial cells of NZB/W mice and increases IL-6 production in vitro
Q34878670MicroRNA: A matter of life or death
Q26865762MicroRNAs and benign biliary tract diseases
Q36324033MicroRNAs in Breastmilk and the Lactating Breast: Potential Immunoprotectors and Developmental Regulators for the Infant and the Mother
Q33991899MicroRNAs in Cholangiopathies
Q37981158MicroRNAs in Hepatobiliary and Pancreatic Cancers
Q36410357MicroRNAs in biliary diseases.
Q30437444MicroRNAs in cancer
Q26783579MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment
Q37287182MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
Q99548917Milk Exosomes: Perspective Agents for Anticancer Drug Delivery
Q39605990Mir-148a improves response to chemotherapy in sensitive and resistant oesophageal adenocarcinoma and squamous cell carcinoma cells.
Q37371743Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes
Q92269858Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells
Q35820533Molecular Targets in Biliary Carcinogenesis and Implications for Therapy
Q37878879Molecular mechanisms of cholangiocarcinoma
Q47153848NcRNAs and Cholangiocarcinoma
Q37280624Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
Q36951319OncomiRs: the discovery and progress of microRNAs in cancers
Q58557374Preliminary study on the effect of nucleolin specific aptamer-miRNA let-7d chimera on Janus kinase-2 expression level and activity in gastric cancer (MKN-45) cells
Q36879784RISCy business: MicroRNAs, pathogenesis, and viruses
Q41977319Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors
Q33994814Recent advances in the regulation of cholangiocarcinoma growth
Q41890041Role of miRNA let-7 and its major targets in prostate cancer.
Q26770485Role of microRNAs in chemoresistance
Q39471126Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration
Q38346740Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells
Q36210966Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma
Q38156148Small RNA regulation of reproductive function
Q38547893Small RNAs: Their Possible Roles in Reproductive Failure
Q36683019The challenge of cholangiocarcinoma: dissecting the molecular mechanisms of an insidious cancer
Q37262636The expression and potential regulatory function of microRNAs in the pathogenesis of leiomyoma
Q38257098The impact of hepatitis B virus x protein and microRNAs in hepatocellular carcinoma: a comprehensive analysis
Q34356918The myriad essential roles of microRNAs in cardiovascular homeostasis and disease
Q26865749The significance of genetics for cholangiocarcinoma development
Q38210867Therapeutic potential of microRNA let-7: tumor suppression or impeding normal stemness.
Q59800406Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages
Q36070235Tumor-suppressive effects of atelocollagen-conjugated hsa-miR-520d-5p on un-differentiated cancer cells in a mouse xenograft model
Q35746187Uterine microRNA signature and consequence of their dysregulation in uterine disorders.
Q37225736Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma
Q91741405Xeno-miRNA in Maternal-Infant Immune Crosstalk: An Aid to Disease Alleviation
Q39638471miR-1228 prevents cellular apoptosis through targeting of MOAP1 protein
Q28303576miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation
Q34241503miR-93 suppresses proliferation and colony formation of human colon cancer stem cells
Q53099936miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma.
Q35086852miRNA regulation of cytokine genes
Q36224336microRNA expression pattern and its alteration following celecoxib intervention in human colorectal cancer
Q38921257microRNA-377 suppresses the proliferation of human osteosarcoma MG-63 cells by targeting CDK6.

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