Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells.

scientific article published on 30 April 2018

Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1802415115
P932PMC publication ID5960326
P698PubMed publication ID29712835

P2093author name stringJianfei Qi
Ladan Fazli
Martin Gleave
Arif Hussain
Xuesen Dong
Lingling Fan
Xiaolu Cui
Fengbo Zhang
Songhui Xu
P2860cites workExpression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survivalQ21091046
NF-κB2/p52:c-Myc:hnRNPA1 Pathway Regulates Expression of Androgen Receptor Splice Variants and Enzalutamide Sensitivity in Prostate CancerQ38865962
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomasQ38967517
Activation of alpha-tropomyosin exon 2 is regulated by the SR protein 9G8 and heterogeneous nuclear ribonucleoproteins H and F.Q39127727
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell linesQ39250655
Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rulesQ39277603
Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.Q39329100
Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progressionQ39605639
Role of Jhdm2a in regulating metabolic gene expression and obesity resistanceQ41876713
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in DrosophilaQ41951844
The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing eventQ46698520
Integrative Clinical Genomics of Advanced Prostate Cancer.Q53788627
Heterogeneous nuclear ribonucleoprotein F/H proteins modulate the alternative splicing of the apoptotic mediator Bcl-xQ81662355
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptorQ24315882
A combinatorial code for splicing silencing: UAGG and GGGG motifsQ24792190
Intronic binding sites for hnRNP A/B and hnRNP F/H proteins stimulate pre-mRNA splicingQ25256959
Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancerQ26777310
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancerQ27853062
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growthQ28116222
The secondary structure of the human immunodeficiency virus type 1 transcript modulates viral splicing and infectivityQ30440740
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancerQ30485336
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variantQ30495758
Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and betaQ30815190
JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner.Q33558243
The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cellsQ33728316
A second exon splicing silencer within human immunodeficiency virus type 1 tat exon 2 represses splicing of Tat mRNA and binds protein hnRNP H.Q33954292
Regulation of alternative splicing by histone modificationsQ34035543
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptorQ34165500
NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognitionQ34977477
Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase 1.Q35575633
Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapiesQ35842471
Influence of RNA secondary structure on the pre-mRNA splicing processQ35968217
Mechanisms of the androgen receptor splicing in prostate cancer cellsQ36005683
Androgen Receptor Splice Variants Dimerize to Transactivate Target GenesQ36021859
Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survivalQ36590632
Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runsQ37160862
Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53.Q37478627
High levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone MetastasesQ38718521
P407language of work or nameEnglishQ1860
P921main subjectalternative mRNA splicing, via spliceosomeQ21114084
P577publication date2018-04-30
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleHistone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells.

Reverse relations

cites work (P2860)
Q92023458A positive role of c-Myc in regulating androgen receptor and its splice variants in prostate cancer
Q91900019AKR1C3 Promotes AR-V7 Protein Stabilization and Confers Resistance to AR-Targeted Therapies in Advanced Prostate Cancer
Q58598144Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer
Q90091985Androgen receptor variant-driven prostate cancer II: advances in laboratory investigations
Q92316366Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications
Q91151375Epigenetic regulation of lung cancer cell proliferation and migration by the chromatin remodeling protein BRG1
Q57106917Genetics and biology of prostate cancer
Q90835355Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells
Q97681497Identification of long non-coding RNAs in advanced prostate cancer associated with androgen receptor splicing factors
Q97646705Role of H3K9 demethylases in DNA double-strand break repair
Q89919982Roles of Splicing Factors in Hormone-Related Cancer Progression
Q64967604Splicing Factors Have an Essential Role in Prostate Cancer Progression and Androgen Receptor Signaling.
Q90059156Targeting USP1-dependent KDM4A protein stability as a potential prostate cancer therapy
Q99711645The Crosstalk Between Epigenetic Mechanisms and Alternative RNA Processing Regulation
Q91826178Understanding aberrant RNA splicing to facilitate cancer diagnosis and therapy

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