Apelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and MEK/Erk pathways.

scientific article

Apelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and MEK/Erk pathways. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11427-015-4861-0
P698PubMed publication ID25951933

P2093author name stringLi Chen
Yong Tao
YanRong Jiang
P2860cites workA human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11Q24336729
The phosphoinositide 3-kinase pathwayQ27860738
Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJQ28143727
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanismQ28198114
Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryoQ28243896
Retardation of retinal vascular development in apelin-deficient miceQ28286058
Apelin is a novel angiogenic factor in retinal endothelial cellsQ28291991
Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microgliaQ28571667
Molecular properties of apelin: tissue distribution and receptor bindingQ28577748
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
Phosphoinositide kinasesQ29618047
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytesQ29619621
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammationQ30481616
Cilostazol is anti-inflammatory in BV2 microglial cells by inactivating nuclear factor-kappaB and inhibiting mitogen-activated protein kinases.Q33767214
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Q33889530
Interleukin 1 in the brain: biology, pathology and therapeutic targetQ34117586
IL-1-regulated responses in astrocytes: relevance to injury and recoveryQ34357276
Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ.Q34600236
Regulatory mechanisms of mitogen-activated kinase signalingQ34668193
Laser-induced choroidal neovascularization in mice attenuated by deficiency in the apelin-APJ systemQ34748519
Involvement of a Stat3 binding site in inflammation-induced enteric apelin expressionQ36977036
The role of inflammatory cytokines in diabetic nephropathy.Q37078749
The multifaceted profile of activated microglia.Q37560782
Microglia in the healthy and degenerating retina: insights from novel mouse modelsQ37767283
Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy.Q37871339
Inflammation in diabetic retinopathyQ37884176
The role of glia in retinal vascular diseaseQ38004034
Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell culturesQ40434588
TNFalpha up-regulates apelin expression in human and mouse adipose tissue.Q42801394
Apelin is a crucial factor for hypoxia-induced retinal angiogenesisQ42938981
Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathyQ43134752
Apelin in epiretinal fibrovascular membranes of patients with retinopathy of prematurity and the changes after intravitreal bevacizumabQ44363219
TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activityQ44903289
Role of interleukin-1beta in the development of retinopathy in rats: effect of antioxidantsQ45124577
Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathyQ46458778
Apelin-13 regulates proliferation, migration and survival of retinal Müller cells under hypoxiaQ46477410
Microglial activation in human diabetic retinopathyQ46758870
Brain cytokine synthesis induced by an intraparenchymal injection of LPS is reduced in MCP-1-deficient mice prior to leucocyte recruitmentQ48457563
P433issue6
P921main subjectinflammationQ101991
microgliaQ1622829
P304page(s)531-540
P577publication date2015-05-08
P1433published inScience in China. Series C: Life SciencesQ2619480
P1476titleApelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and MEK/Erk pathways.
P478volume58

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cites work (P2860)
Q92838048Apelin induces the proliferation, migration and expression of cytoskeleton and tight junction proteins in human RPE cells via PI-3K/Akt and MAPK/Erk signaling pathways
Q54944071Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3K/Akt and MAPK/Erk Signaling Pathways.
Q64062305Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway
Q47978333CNS Targets of Adipokines
Q64111949Cascade Signals of Papaverine Inhibiting LPS-Induced Retinal Microglial Activation
Q27316188Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.
Q37594223Effect of the PI3K/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells
Q47578701Effects of apelin on retinal microglial cells in a rat model of oxygen-induced retinopathy of prematurity.
Q38728549Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth
Q40261085Neurodegeneration in Diabetic Retinopathy: Current Concepts and Therapeutic Implications
Q59329094Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina

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