The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore.

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The presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore. is …
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scholarly articleQ13442814

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P356DOI10.1111/J.1432-1033.1990.TB15667.X
P698PubMed publication ID2176603

P2093author name stringA Costi
M Crompton
N Yafei
O McGuinness
P2860cites workPeptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilinQ24338951
Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteinsQ29618460
Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeniQ38340859
The entrapment of the Ca2+ indicator arsenazo III in the matrix space of rat liver mitochondria by permeabilization and resealing. Na+-dependent and -independent effluxes of Ca2+ in arsenazo III-loaded mitochondriaQ38350395
The importance of free radicals and catalytic metal ions in human diseasesQ39837663
A heart mitochondrial Ca2(+)-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open statesQ41782125
Cytosolic free Ca2+ in single rat heart cells during anoxia and reoxygenationQ41955683
The reversible Ca2+-induced permeabilization of rat liver mitochondriaQ42067210
Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondriaQ42163611
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
cyclosporineQ367700
P304page(s)671-679
P577publication date1990-12-01
P1433published inFEBS JournalQ1388041
P1476titleThe presence of two classes of high-affinity cyclosporin A binding sites in mitochondria. Evidence that the minor component is involved in the opening of an inner-membrane Ca(2+)-dependent pore.
P478volume194