The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.

scientific article

The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCISIGNAL.AAN4144
P932PMC publication ID6462218
P698PubMed publication ID29717061

P50authorAkiko IwasakiQ19958193
Kachiko HayashiQ88537649
Manabu TauraQ88537652
P2093author name stringKachiko Hayashi
Manabu Taura
P2860cites workToll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cellsQ36371359
Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.Q36402885
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferonQ36498450
Type I interferon in systemic lupus erythematosus and other autoimmune diseasesQ36595839
RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cellsQ36880014
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells.Q37050067
Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexesQ37206862
Non-canonical NF-κB signaling pathwayQ37822660
Biogenesis and cargo selectivity of autophagosomesQ37872765
Autophagy and autophagy-related proteins in the immune systemQ38588827
Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.Q40037557
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon inductionQ40437839
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} inductionQ40446857
IKK-dependent, NF-κB-independent control of autophagic gene expression.Q42186872
IKKα controls ATG16L1 degradation to prevent ER stress during inflammationQ42323488
Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3Q42702955
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradationQ42972278
Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.Q54689085
A Toll-like receptor recognizes bacterial DNAQ24290668
Network organization of the human autophagy systemQ24324004
The IKK complex contributes to the induction of autophagyQ24329117
The LIR motif - crucial for selective autophagyQ26825455
Structural basis of target recognition by Atg8/LC3 during selective autophagyQ27652961
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptorsQ27860900
Atg8: an autophagy-related ubiquitin-like protein familyQ28246433
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9Q28507728
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6Q28584723
Identification of a candidate therapeutic autophagy-inducing peptideQ28593490
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cellsQ28594284
The role of autophagy during the early neonatal starvation periodQ29547489
Autophagy-dependent viral recognition by plasmacytoid dendritic cellsQ29614177
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisQ29614481
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral responseQ29617083
Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.Q33794944
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implicationsQ34583474
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cellsQ35768621
Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activityQ36027805
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteinsQ36181466
The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3Q36371303
P433issue528
P921main subjecttoll-like receptorQ408004
P577publication date2018-05-01
P1433published inScience SignalingQ7433604
P1476titleThe interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome
P478volume11

Reverse relations

cites work (P2860)
Q58803163A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics
Q94465336Autophagy Is a Potential Therapeutic Target Against Duck Tembusu Virus Infection in vivo
Q92353405Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
Q64250849Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity
Q92766138Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells
Q89574004DNA Sensing in the Innate Immune Response
Q89078318Effect of high glucose on cytokine production by human peripheral blood immune cells and type I interferon signaling in monocytes: Implications for the role of hyperglycemia in the diabetes inflammatory process and host defense against infection
Q92209913Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)
Q93198245Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis
Q57054228LAP it up, fuzz ball: a short history of LC3-associated phagocytosis
Q91759731LC3-associated phagocytosis at a glance
Q60952270Macropinocytosis and autophagy crosstalk in nutrient scavenging
Q64079632Mapping of Signaling Pathways Linked to sIgAD Reveals Impaired IL-21 Driven STAT3 B-Cell Activation
Q58199388Molecular dissection of plasmacytoid dendritic cell activation during a viral infection
Q96136653Plasmacytoid dendritic cell biology and its role in immune-mediated diseases

Search more.