Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis

scientific article published on 27 December 2019

Autophagy and Macrophage Functions: Inflammatory Response and Phagocytosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS9010070
P932PMC publication ID7016593
P698PubMed publication ID31892110

P50authorJiahong LuQ59693022
P2093author name stringMing-Yue Wu
P2860cites workActivation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destructionQ24303900
The inflammasomesQ24304087
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growthQ24304447
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune responseQ24316320
Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturationQ24322789
AMPK phosphorylation of raptor mediates a metabolic checkpointQ24329244
Indomethacin suppresses LAMP-2 expression and induces lipophagy and lipoapoptosis in rat enterocytes via the ER stress pathway.Q44616132
Sorafenib induces autophagy and suppresses activation of human macrophageQ45203186
Fatty acid synthesis configures the plasma membrane for inflammation in diabetesQ45894590
Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese populationQ46869773
Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling.Q48190373
Cellular and molecular mechanism for secretory autophagyQ48336628
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.Q50002350
The Salmonella effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication.Q52334093
A brief history of autophagy from cell biology to physiology and disease.Q52568575
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1.Q52678418
Autophagy dictates metabolism and differentiation of inflammatory immune cells.Q53112796
NF-κB as a central regulator of macrophage function in tumors.Q53316905
The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.Q54113162
Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils.Q54260270
Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages.Q54354288
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.Q54520926
LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune ToleranceQ57025342
Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling AxisQ58746351
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagyQ64082026
The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading BacteriaQ64103312
MicroRNA-326 suppresses iNOS expression and promotes autophagy of dopaminergic neurons through the JNK signaling by targeting XBP1 in a mouse model of Parkinson's diseaseQ64764729
Rab5-dependent autophagosome closure by ESCRT.Q64971553
A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates XenophagyQ68472446
The non-canonical role of Atg family members as suppressors of innate antiviral immune signalingQ81407624
Autophagy modulates osteoarthritis-related gene expression in human chondrocytesQ82837043
Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsisQ88410634
Autophagy in the renewal, differentiation and homeostasis of immune cellsQ90371605
iNOS Interacts with Autophagy Receptor p62 and is Degraded by Autophagy in MacrophagesQ90749110
Autophagy induction via STING trafficking is a primordial function of the cGAS pathwayQ92179904
The NF-κB Factor Relish Regulates Atg1 Expression and Controls AutophagyQ93274007
The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMOQ24336822
Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIPQ24337587
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolismQ24337667
Cyclic di-GMP sensing via the innate immune signaling protein STINGQ24338485
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathwayQ24601311
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammationQ24609294
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesisQ24656576
Tissue-resident macrophagesQ26991488
Mechanisms of inflammasome activation: recent advances and novel insightsQ27005760
Macrophage Receptor with Collagenous Structure (MARCO) Is Processed by either Macropinocytosis or Endocytosis-Autophagy PathwayQ27346886
Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagyQ27349252
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagyQ27933717
Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusionQ27933991
A protein conjugation system essential for autophagyQ27940154
An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathwaysQ28139919
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateQ28187453
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosusQ28261767
TRAF6 is a signal transducer for interleukin-1Q28291934
Requirement of DNase II for definitive erythropoiesis in the mouse fetal liverQ28508639
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagyQ28585634
The TBK1-binding domain of optineurin promotes type I interferon responsesQ28771750
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome MaturationQ29030353
Monocyte and macrophage heterogeneityQ29547438
Alternative activation of macrophages: mechanism and functionsQ29614350
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta productionQ29614472
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisQ29614481
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1Q29614873
The family of five: TIR-domain-containing adaptors in Toll-like receptor signallingQ29615457
Synaptic pruning by microglia is necessary for normal brain developmentQ29615591
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryQ29615618
Macrophage diversity enhances tumor progression and metastasisQ29615847
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responsesQ37632327
The NF-kappaB family of transcription factors and its regulationQ37672294
Protein sorting receptors in the early secretory pathwayQ37763713
Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapterQ37921944
Signaling in innate immunity and inflammationQ37980557
Metabolism of inflammation limited by AMPK and pseudo-starvationQ38074586
Metabolic pathways in immune cell activation and quiescenceQ38100361
Intracellular trafficking and secretion of inflammatory cytokinesQ38104469
Autophagy and cellular immune responsesQ38131217
A20 in inflammation and autoimmunityQ38163677
Autophagy in antimicrobial immunityQ38207186
Cargo recognition and trafficking in selective autophagyQ38215949
Autophagy and autophagy-related proteins in the immune systemQ38588827
Macrophage Immunometabolism: Where Are We (Going)?Q38732304
Phagocytosis: An Immunobiologic ProcessQ38776882
Cellular Functions of Optineurin in Health and DiseaseQ38915157
Clearance of apoptotic neutrophils and resolution of inflammationQ38936566
TLR2 mediates phagocytosis and autophagy through JNK signaling pathway in Staphylococcus aureus-stimulated RAW264.7 cellsQ39035405
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent mannerQ39062783
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained ImmunityQ39170824
mTORC1 signaling and the metabolic control of cell growthQ39243905
AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic BalanceQ39378752
Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathwayQ39404614
Two distinct classes of carbohydrate-recognition domains in animal lectinsQ39648429
Listeria monocytogenes ActA-mediated escape from autophagic recognitionQ39800150
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties.Q39837169
p65/RelA modulates BECN1 transcription and autophagyQ39872195
TRIM-directed selective autophagy regulates immune activationQ40113749
Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation.Q40120827
Regulation of autophagy by NFkappaB transcription factor and reactives oxygen speciesQ40138941
Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK).Q40211366
Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient miceQ40250591
Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas SepsisQ40309248
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host DefenseQ40395820
Escape of intracellular Shigella from autophagyQ40485419
TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.Q40528170
TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective AutophagyQ40585385
The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.Q41590212
TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction.Q41612118
Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorptionQ41772601
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signalingQ41851410
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage HomeostasisQ41863769
AMPK and autophagy get connected.Q41874222
Btk regulates macrophage polarization in response to lipopolysaccharide.Q41882583
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switchQ42033503
Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genesQ42503387
Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles.Q36287059
Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.Q36298354
TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation.Q36603144
NF-κB Restricts Inflammasome Activation via Elimination of Damaged MitochondriaQ36625160
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axisQ36667276
Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation.Q36769730
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infectionQ36781320
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infectionQ36829036
RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cellsQ36880014
IRAK1: a critical signaling mediator of innate immunityQ36949358
MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.Q36981000
Fusion, fission, and secretion during phagocytosisQ37029648
Secretory versus degradative autophagy: unconventional secretion of inflammatory mediatorsQ37046163
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signalingQ37115242
Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia CellsQ37145468
Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexesQ37206862
Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin's lymphoma cellsQ37299640
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of InflammationQ37412828
The ubiquitin ligase parkin mediates resistance to intracellular pathogensQ37458253
Development of monocytes, macrophages, and dendritic cellsQ29616446
A lineage of myeloid cells independent of Myb and hematopoietic stem cellsQ29620147
Macrophage biology in development, homeostasis and diseaseQ29620350
Toll-like receptors control autophagy.Q30481722
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell inductionQ30496577
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.Q30559146
Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injuryQ31136783
CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarizationQ33553562
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repairQ33565774
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.Q33652731
Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in MacrophagesQ33681241
Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritisQ33729300
Bacterial Autophagy: Offense and Defense at the Host-Pathogen InterfaceQ33824141
Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophageQ33858542
Triggering TLR2, -3, -4, -5, and -8 reinforces the restrictive nature of M1- and M2-polarized macrophages to HIV.Q34059582
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Q34084866
The immune system in atherosclerosisQ34164644
Genomic analysis of C-type lectinsQ34185907
The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregatesQ34311564
The C-type lectin-like domain superfamilyQ34473873
Regulation of steady-state neutrophil homeostasis by macrophages.Q34542130
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradationQ34684708
TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS).Q35079488
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammationQ35083309
Regulation of immunity and inflammation by mediators from macrophagesQ35303428
Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cellsQ35409371
Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophagesQ35439832
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate AutophagyQ35738682
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagyQ35749637
Autophagy and mechanisms of effective immunityQ35928336
The Atg5 Atg12 conjugate associates with innate antiviral immune responsesQ35956883
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.Q36000076
Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesiclesQ36100748
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMMLQ36111614
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteinsQ36181466
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectmacrophageQ184204
phagocytosisQ184726
autophagyQ288322
P577publication date2019-12-27
P1433published inCellsQ27724621
P1476titleAutophagy and Macrophage Functions: Inflammatory Response and Phagocytosis
P478volume9

Reverse relations

cites work (P2860)
Q90149217NLRP3 Inflammasome and Inflammatory Diseases
Q99414286Roles of Specialized Pro-Resolving Lipid Mediators in Autophagy and Inflammation

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