Mechanism of poly(ethylene glycol) interaction with proteins.

scientific article published in November 1985

Mechanism of poly(ethylene glycol) interaction with proteins. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/BI00345A005
P698PubMed publication ID4074726

P2093author name stringArakawa T
Timasheff SN
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)6756-6762
P577publication date1985-11-01
P1433published inBiochemistryQ764876
P1476titleMechanism of poly(ethylene glycol) interaction with proteins.
P478volume24

Reverse relations

cites work (P2860)
Q41780163'Macromolecular crowding' is a primary factor in the organization of the cytoskeleton
Q30331631A comparison between the protection of LDH during freeze-thawing by PEG 6000 and Brij 35 at low concentrations.
Q92133344A stepwise mechanism for aqueous two-phase system formation in concentrated antibody solutions
Q77333732Acetonitrile-protein interactions: amino acid solubility and preferential solvation
Q53868893Adhesion barriers of carboxymethylcellulose and polyethylene oxide composite gels.
Q74171451Application of aqueous two-phase partition to the production of homogeneous preparations of fluorescently labelled human serum albumin
Q34177978Assessing accumulated solvent near a macromolecular solute by preferential interaction coefficients
Q39461755Changes in the lipid dynamics of liposomal membranes induced by poly(ethylene glycol): free volume alterations revealed by inter- and intramolecular excimer-forming phospholipid analogs
Q42111378Characterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability
Q67931693Chromatography of proteins on hydrophobic interaction and ion-exchange chromatographic matrices: mobile phase contributions to selectivity
Q27664265Conformational exchange in a membrane transport protein is altered in protein crystals
Q67528181Cosolvent assisted protein refolding
Q37980653Current strategies and future perspectives for intraperitoneal adhesion prevention
Q41761416Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers
Q45996801Densimetric determination of carbohydrate content in glycoproteins
Q57136663Destabilization of human serum albumin by polyethylene glycols studied by thermodynamical equilibrium and kinetic approaches
Q40272005Dielectric behavior of lysozyme and ferricytochrome-c in water/ethylene-glycol solutions
Q43628327Dimethylsulfoxide promotes K+-independent activity of pyruvate kinase and the acquisition of the active catalytic conformation
Q57691292Effect of compatible and noncompatible osmolytes on the enzymatic activity and thermal stability of bovine liver catalase
Q52538087Effect of ethanol and osmotic stress on receptor conformation. Reduced water activity amplifies the effect of ethanol on metarhodopsin II formation.
Q36242272Effect of interior loop length on the thermal stability and pK(a) of i-motif DNA
Q48916206Effect of partial PEGylation on particle uptake by macrophages.
Q34392528Effect of polyethylene glycol on the liquid-liquid phase transition in aqueous protein solutions
Q57111659Effects of Dimethyl Sulfoxide, Glycerol, and Ethylene Glycol on Secondary Structures of Cytochrome c and Lysozyme As Observed by Infrared Spectroscopy
Q80289328Effects of additives on the thermostability of chloroperoxidase
Q44020867Effects of polyhydroxy compounds on the structure and activity of alpha-chymotrypsin
Q57345795Enhanced protein renaturation by temperature-responsive polymers
Q46629434Estimation of recombinant bovine somatotropin solubility by excluded-volume interaction with polyethylene glycols
Q50275761Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation
Q88959635Excluded Cosolvent in Chromatography
Q34190379Factors affecting short-term and long-term stabilities of proteins
Q41949814Factors affecting the antigen-antibody reaction
Q39036104Galactosylated poly(ethylene glycol) methacrylate-st-3-guanidinopropyl methacrylamide copolymers as siRNA carriers for inhibiting Survivin expression in vitro and in vivo
Q34177270Hydration effects of heparin on antithrombin probed by osmotic stress
Q30538937Hydration of polyethylene glycol-grafted liposomes
Q34168531Hydration structure of antithrombin conformers and water transfer during reactive loop insertion
Q36487081In disperse solution, "osmotic stress" is a restricted case of preferential interactions
Q90150120Interrogating Cellular Functions with Designer Janus Particles
Q37872687Intraperitoneal adhesions--an ongoing challenge between biomedical engineering and the life sciences
Q90547946Investigation of the reversibility of freeze/thaw stress-induced protein instability using heat cycling as a function of different cryoprotectants
Q43655452Large solutes induce structural perturbations in proteins and membranes
Q38363126Large-scale crystallization of proteins for purification and formulation
Q34185062Liquid-liquid phase separation in hemoglobins: distinct aggregation mechanisms of the beta6 mutants
Q36540464Measurements of attractive forces between proteins and end-grafted poly(ethylene glycol) chains
Q47632778Metastability Gap in the Phase Diagram of Monoclonal IgG Antibody
Q33330366Micropallet arrays with poly(ethylene glycol) walls
Q39310346Mineralization and non-ideality: on nature's foundry
Q73137221Modeling of adsorption in hydrophobic interaction chromatography systems using a preferential interaction quadratic isotherm
Q35562174Molecular crowding enhances facilitated diffusion of two human DNA glycosylases
Q34370891Molecular dynamics simulations on aqueous two-phase systems - Single PEG-molecules in solution
Q40413633Molecular mechanisms for passive and active transport of water.
Q63347521New Insight into the Role of Polyethylene Glycol Acting as Protein Release Modifier in Lipidic Implants
Q74590992New stable folding of beta-lactoglobulin induced by 2-propanol
Q46071368Oligoethylene glycols prevent thermal aggregation of α-chymotrypsin in a temperature-dependent manner: implications for design guidelines
Q96127052On the Aggregation and Nucleation Mechanism of the Monoclonal Antibody Anti-CD20 Near Liquid-Liquid Phase Separation (LLPS)
Q46400045Opposing effects of two osmolytes--trehalose and glycerol--on thermal inactivation of rabbit muscle 6-phosphofructo-1-kinase.
Q44320010Oral colon lavage solutions containing polyethylene glycol may interfere with ELISA detection of tumor-associated antigens in colonic effluent
Q36255206Osmolyte-driven contraction of a random coil protein
Q30433385Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins
Q40900136PEG-variant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration
Q43944417PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation.
Q39660719Phospholipase A2 as a mechanosensor
Q73459355Plasma-deposited membranes for controlled release of antibiotic to prevent bacterial adhesion and biofilm formation
Q42169550Poly(ethylene glycol) doubly and singly cationized by different alkali metal ions: relative cation affinities and cation-dependent resolution in a quadrupole ion trap mass spectrometer.
Q57349263Poly(ethylene glycol): Protein-repulsive or albumin-compatible?
Q47770993Polyethylene glycol 4000 attenuates adhesion formation in rats by suppression of peritoneal inflammation and collagen incorporation
Q41765907Polyethylene glycol-induced precipitation of interferon alpha-2a followed by vacuum drying: development of a novel process for obtaining a dry, stable powder
Q34171907Polymeric nonelectrolytes to probe pore geometry: application to the alpha-toxin transmembrane channel
Q35730064Preferential Interactions and the Effect of Protein PEGylation.
Q53851582Preferential hydration and the exclusion of cosolvents from protein surfaces.
Q44590337Preferential interactions of urea with lysozyme and their linkage to protein denaturation
Q67907003Protein adsorption to poly(ethylene oxide) surfaces
Q30332236Protein formulation and fill-finish operations.
Q36982552Protein stability during freezing: separation of stresses and mechanisms of protein stabilization
Q47338048Protein-solvent interaction
Q34075314Protein-solvent preferential interactions, protein hydration, and the modulation of biochemical reactions by solvent components
Q37946879Proteins under extreme physical conditions
Q50273109Purification of proteins from solutions containing residual host cell proteins via preparative crystallization
Q30476790Radial compression of microtubules and the mechanism of action of taxol and associated proteins.
Q92854538Recovery of Polyphenols from Grape Pomace Using Polyethylene Glycol (PEG)-Grafted Silica Particles and PEG-Assisted Cosolvent Elution
Q42843093Refolding and proton pumping activity of a polyethylene glycol-bacteriorhodopsin water-soluble conjugate
Q43777326Regulation of glycosaminoglycan function by osmotic potentials. Measurement of water transfer during antithrombin activation by heparin
Q44329006SPE and purification of DNA using magnetic particles
Q47863270Self-interaction chromatography: a tool for the study of protein-protein interactions in bioprocessing environments
Q34040753Serge Timasheff: the man with a genius for solutions in biology
Q67954121Should we let sleeping PEGs lie?
Q47253049Size-Selective Harvesting of Extracellular Vesicles for Strategic Analyses Towards Tumor Diagnoses
Q92853632Stabilization of Intrinsically Disordered DKK2 Protein by Fusion to RNA-Binding Domain
Q73170236Stabilization of insulin against agitation-induced aggregation by the GMO cubic phase gel
Q71744528Stabilization of recombinant human keratinocyte growth factor by osmolytes and salts
Q47701128Stabilization of the water oxidizing polypeptide assembly on Photosystem II membranes by osmolytes and other solutes
Q30333565Steric exclusion is the principal source of the preferential hydration of proteins in the presence of polyethylene glycols
Q41649776Structure as basis for understanding interfacial properties of lipases
Q71695665Swelling and viscoelastic properties of osmotically stressed elastin
Q28306938The Hofmeister effect and the behaviour of water at interfaces
Q34176870The effect of water on the rate of conformational change in protein allostery
Q39713591The mechanism of cryoprotection of proteins by solutes
Q30157350The osmolyte trimethylamine-N-oxide stabilizes the Fyn SH3 domain without altering the structure of its folding transition state
Q72125209The stabilization of a human IgM monoclonal antibody with poly(vinylpyrrolidone)
Q57367781The synthesis and self-assembly of bioconjugates composed of thermally-responsive polymer chains and pendant lysozyme molecules
Q27676377The use of trimethylamineN-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography
Q47373166Thermal stability of low molecular weight urokinase during heat treatment. II. Effect of polymeric additives
Q35028518Thermodynamic binding and site occupancy in the light of the Schellman exchange concept
Q35895112Toward a molecular understanding of protein solubility: increased negative surface charge correlates with increased solubility
Q47287226Transition of a compact intermediate state of pea lectin under the influence of different molecular weight polyethylene glycols
Q44813794Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres?
Q47681572[8] Using cosolvents to stabilize protein conformation for crystallization