Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib.

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Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JNCI/DJV307
P698PubMed publication ID26563356

P2093author name stringSiraj M Ali
Vincent A Miller
Philip J Stephens
Jeffrey S Ross
Victor Wong
John Crawford
Roman Yelensky
Dean Pavlick
Tim Brennan
Hyunah Ahn
Denise Malicki
P2860cites workOncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.Q27852601
Infantile fibrosarcoma: management based on the European experience.Q33516050
Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcomaQ34754714
Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissuesQ38462062
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cellsQ41813875
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencingQ47163678
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcrizotinibQ5186964
comprehensive genomic profilingQ114107212
P577publication date2015-11-12
P1433published inJournal of the National Cancer InstituteQ400279
P1476titleEvaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib.
P478volume108

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cites work (P2860)
Q57055324A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes
Q58720733A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report
Q38891711Causes and consequences of nuclear envelope alterations in tumour progression
Q55003763Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.
Q36257816FuGePrior: A novel gene fusion prioritization algorithm based on accurate fusion structure analysis in cancer RNA-seq samples.
Q96302702Histology-agnostic drug development - considering issues beyond the tissue
Q46229973Identification of NTRK fusions in pediatric mesenchymal tumors
Q58080406Immunohistochemical Correlates of Recurrent Genetic Alterations in Sarcomas
Q37357286Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101.
Q54117764Inhibiting TRK Proteins in Clinical Cancer Therapy.
Q89842057Integrative clinical and biopathology analyses to understand the clinical heterogeneity of infantile rhabdomyosarcoma: A report from the French MMT committee
Q54958100Lipofibromatosis-like neural tumor: Case report of a unique infantile presentation.
Q54981810Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Q51733074NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma.
Q52885342Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic/haemangiopericytic pattern.
Q38956444Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions
Q36350870Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells.
Q47649693Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas: Expanding the Genetic Spectrum of Tumors With Overlapping Features With Infantile Fibrosarcoma
Q48368768Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy.
Q41631541Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors
Q48151927Recurrent and metastatic congenital mesoblastic nephroma: where does the evidence stand?
Q55289701Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.
Q64237933Refractory and metastatic infantile fibrosarcoma harboring fusion shows complete and durable response to crizotinib
Q98386647Successful treatment of lipofibromatosis-like neural tumor of the lumbar spine with an NTRK-fusion inhibitor
Q57815366Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors
Q57050736TRK Inhibition: A New Tumor-Agnostic Treatment Strategy
Q55422121The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.

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