Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS.

scientific article published on 25 May 2016

Glycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPREGU.00043.2016
P698PubMed publication ID27225947

P2093author name stringJing Zhang
Huiling Zhu
Yulan Liu
Guolong Zhang
Xiuying Wang
Yongqing Hou
Chien-An Andy Hu
Huanting Wu
Shaokui Chen
P2860cites workAccurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesQ24534395
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Pattern recognition receptors and inflammationQ27861115
The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancerQ33874156
Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trialQ33968290
Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammationQ33988273
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and womenQ34179131
Regulation of muscle protein synthesis during sepsis and inflammationQ34628735
Double or bifid zygomaticus major muscle: Anatomy, incidence, and clinical correlationQ34751906
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agentQ35067484
Regulation of protein synthesis by amino acids in muscle of neonatesQ35114422
Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in miceQ35178582
Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigsQ35842227
Molecular and cellular mechanisms of skeletal muscle atrophy: an update.Q36179105
Regulation of muscle growth by pathogen-associated moleculesQ37056056
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders.Q37596057
Glycine metabolism in animals and humans: implications for nutrition and healthQ38101481
N-acetylcysteine stimulates protein synthesis in enterocytes independently of glutathione synthesisQ38830489
Glycine stimulates protein synthesis and inhibits oxidative stress in pig small intestinal epithelial cellsQ38966151
Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexiaQ39128938
Supplementation with l-carnitine downregulates genes of the ubiquitin proteasome system in the skeletal muscle and liver of pigletsQ39375978
Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubesQ39503456
NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin ResistanceQ39647567
Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionineQ40056140
Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2).Q40121808
Structure and biology of inhibitory glycine receptorsQ41460071
Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophyQ42011965
Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinaseQ42169148
Effect of spray-dried plasma and lipopolysaccharide exposure on weaned pigs: I. Effects on the immune axis of weaned pigsQ42518312
Dietary supplementation of glycine modulates inflammatory response indicators in broiler chickensQ42526260
Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signalingQ42800302
Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscleQ44107264
Glycine modulates cytokine secretion, inhibits hepatic damage and improves survival in a model of endotoxemia in miceQ44535183
Dietary glycine prevents chemical-induced experimental colitis in the rat.Q44569538
Metabolomic analysis reveals differences in umbilical vein plasma metabolites between normal and growth-restricted fetal pigs during late gestationQ46324390
A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle.Q46346112
Downregulation of muscle protein degradation in sepsis by eicosapentaenoic acid (EPA).Q46429807
Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cellsQ46530971
Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscleQ46681308
Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigsQ46753293
Effects of orally administered glycine on myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle in chicksQ48393417
Aspartate alleviates liver injury and regulates mRNA expressions of TLR4 and NOD signaling-related genes in weaned pigs after lipopolysaccharide challengeQ50667849
Enteral feeding decreases gut apoptosis, permeability, and lung inflammation during murine endotoxemiaQ51548210
Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challengeQ54290216
Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigsQ54339899
Glycine-induced cytoprotection is mediated by ERK1/2 and AKT in renal cells with ATP depletion.Q54629406
P433issue2
P921main subjecttoll-like receptorQ408004
P304page(s)R365-73
P577publication date2016-05-25
P1433published inAmerican Journal of Physiology - Regulatory, Integrative and Comparative PhysiologyQ2201819
P1476titleGlycine enhances muscle protein mass associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing TLR4 and NOD2 signaling in piglets challenged with LPS.
P478volume311

Reverse relations

cites work (P2860)
Q58692935Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury
Q41255629Glutamate alleviates muscle protein loss by modulating TLR4, NODs, Akt/FOXO and mTOR signaling pathways in LPS-challenged piglets.
Q90186430Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial
Q42368204Therapeutic Potential of Amino Acids in Inflammatory Bowel Disease

Search more.