Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

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Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCB2977
P698PubMed publication ID24880666

P50authorEduard BatlleQ42353440
Roger GomisQ42846404
Ramón ManguesQ55603191
Sylwia GawrzakQ57051075
Francisco M BarrigaQ64786171
P2093author name stringAngel R Nebreda
Nancy Kemeny
María Virtudes Céspedes
Evarist Planet
Cristina Nadal
Ignacio Dolado
Anna Bellmunt
Jelena Urosevic
Marc Guiu
Esther Fernandez
Milica Pavlovic
Xabier Garcia-Albéniz
Sebastián Real
P2860cites workBioconductor: open software development for computational biology and bioinformaticsQ21194861
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Two distinct pathways leading to nuclear apoptosisQ24676123
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell deathQ28209183
Genome remodelling in a basal-like breast cancer metastasis and xenograftQ28395637
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisitedQ29547915
Metastasis: from dissemination to organ-specific colonizationQ29614295
Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potentialQ30478479
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling eventsQ33789562
Molecular mechanisms of osteolytic bone metastasesQ33909842
Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal CancerQ34062558
Mechanisms and functions of p38 MAPK signalling.Q34125736
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapseQ34171959
BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle inductionQ34575583
Follow-up of patients with colorectal cancer: numbers needed to test and treatQ34615990
Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivoQ34825844
Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitorsQ35768629
Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.Q35781371
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.Q36073367
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancerQ36570605
Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.Q36599592
Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formationQ36948482
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
Metastatic colorectal cancer: from improved survival to potential cureQ37762682
Meeting the biologic challenge of colorectal metastasesQ38051068
Parathyroid-related protein plays a critical role in bone invasion by oral squamous cell carcinoma.Q39709554
An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell deathQ39937441
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imagingQ40579830
Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strengthQ40852104
Serum matrilysin levels predict outcome in curatively resected colorectal cancer patients.Q51787558
Semi-parametric differential expression analysis via partial mixture estimation.Q51887194
Serum matrilysin correlates with poor survival independently of KRAS and BRAF status in refractory advanced colorectal cancer patients treated with irinotecan plus cetuximab.Q54630883
KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal CancerQ57092215
Metastatic behavior of tumor cells isolated from primary and metastatic human colorectal carcinomas implanted into different sites in nude miceQ60043810
Parathyroid hormone-related protein expression in the human colon: immunohistochemical evaluationQ71126531
Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten yearsQ79193052
Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidateQ82985233
P433issue7
P921main subjectcolon cancerQ18555025
P304page(s)685-694
P577publication date2014-06-01
P1433published inNature Cell BiologyQ1574111
P1476titleColon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH
P478volume16

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cites work (P2860)
Q35724108ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion
Q37685867Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
Q33591502Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer
Q47138859Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling
Q37573461Cancer and the metastatic substrate
Q91712271Cathepsin C Interacts with TNF-α/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma
Q35849038Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome
Q39722702Codon 13 KRAS mutation predicts patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases
Q39085740Determinants of metastatic competency in colorectal cancer
Q93122630Differential gene expression in bovine endometrial epithelial cells after challenge with LPS; specific implications for genes involved in embryo maternal interactions
Q37732988Down-regulation of miR-125a-5p is associated with salivary adenoid cystic carcinoma progression via targeting p38/JNK/ERK signal pathway
Q92895803Effects of somatic alterations at pathway level are more mechanism-explanatory and clinically applicable to quantity of liver metastases of colorectal cancer
Q107162147Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
Q64913565Fibroblast growth factor 18 promotes the growth, migration and invasion of MDA‑MB‑231 cells.
Q47282038HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis.
Q35600057Hidden among the crowd: differential DNA methylation-expression correlations in cancer occur at important oncogenic pathways
Q58792082Hsp27 regulates epithelial mesenchymal transition, metastasis and proliferation in colorectal carcinoma
Q50086554Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?
Q26772279Impact of somatic mutations on patterns of metastasis in colorectal cancer
Q36645236Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination.
Q34332372Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression
Q58772874Interaction between Tumor-Associated Dendritic Cells and Colon Cancer Cells Contributes to Tumor Progression via CXCL1
Q92125845Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B
Q60960764Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203
Q103740472Long noncoding RNA lncGALM increases risk of liver metastasis in gallbladder cancer through facilitating N-cadherin and IL-1β-dependent liver arrest and tumor extravasation
Q35959009Lung microenvironment promotes the metastasis of human hepatocellular carcinoma cells to the lungs.
Q43002710MAPK signaling control of colon cancer metastasis
Q48190414MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer
Q38667176Management of resectable colorectal lung metastases
Q28076164Metastatic colonization by circulating tumour cells
Q47161788NRAS destines tumor cells to the lungs
Q90215566Organ-specific metastases
Q60307719Overexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion
Q58561619PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway
Q38671275Pattern and Dynamics of Distant Metastases in Metastatic Colorectal Cancer
Q38614956Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation
Q35929836RARRES3 suppressed metastasis through suppression of MTDH to regulate epithelial-mesenchymal transition in colorectal cancer
Q35911017RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer
Q37622594Reconstructing metastatic seeding patterns of human cancers
Q33802043Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma
Q38366515Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.
Q54980437STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway.
Q38776725Silencing TAK1 alters gene expression signatures in bladder cancer cells
Q35202991Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases
Q38676055Surviving at a distance: organ specific metastasis
Q60054767TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma
Q89658448Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
Q91600784The Molecular Basis of Metastatic Colorectal Cancer
Q95643120The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer
Q90308758The p38 Pathway: From Biology to Cancer Therapy
Q55430424Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer.
Q28073065Tumor cell dormancy
Q64058072UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer
Q42353406Understanding the molecular mechanisms driving metastasis

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