Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

scientific article published on 07 February 2020

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS21031102
P932PMC publication ID7037308
P698PubMed publication ID32046099

P50authorWalter KolchQ30504262
Jens RauchQ37837239
P2093author name stringShannon Lee
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c-Jun N-Terminal Kinase Inactivation by Mitogen-Activated Protein Kinase Phosphatase 1 Determines Resistance to Taxanes and Anthracyclines in Breast Cancer.Q38733953
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Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.Q54348724
The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation.Q54977412
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.Q54978327
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p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathwayQ58326859
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p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2Q64377557
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AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and PaclitaxelQ90029648
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Reduced NF1 expression confers resistance to EGFR inhibition in lung cancerQ33572728
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The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer.Q34005738
p38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.Q34008781
Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formationQ34104152
Mechanisms and functions of p38 MAPK signalling.Q34125736
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitorsQ34248395
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascadeQ34281252
Cancer Genetics and Epigenetics: Two Sides of the Same Coin?Q34287662
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The Warburg Effect: How Does it Benefit Cancer Cells?Q34509467
Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancersQ34615545
P38 MAPK contributes to resistance and invasiveness of HER2- overexpressing breast cancerQ34675545
The role of JNK in the development of hepatocellular carcinomaQ34691340
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinaseQ34720797
Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanismQ34742599
Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic functionQ34745057
Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomasQ35018167
The Warburg effect: evolving interpretations of an established conceptQ35169587
Therapeutic control and resistance of the EGFR-driven signaling network in glioblastomaQ35341639
JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases.Q35822826
Oncogene addiction as a foundational rationale for targeted anti‐cancer therapy: promises and perilsQ36038823
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.Q36140332
PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibitionQ36215920
Activated estrogen receptor-mitogen-activated protein kinases cross talk confer acquired resistance to lapatinibQ36247858
IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.Q36266768
Targeting the MAPK-RAS-RAF signaling pathway in cancer therapyQ36278239
MEK1/2 Inhibitors: Molecular Activity and Resistance MechanismsQ36328021
Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanismsQ36338753
PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal CancerQ36437685
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cellsQ36476849
Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate TransactivationQ36531161
Infiltrating mast cells increase prostate cancer chemotherapy and radiotherapy resistances via modulation of p38/p53/p21 and ATM signalsQ36738823
Interfering with MAP kinase docking interactions: implications and perspective for the p38 routeQ36757177
Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cellsQ36907149
Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activationQ36907156
p38 MAPK-induced MDM2 degradation confers paclitaxel resistance through p53-mediated regulation of EGFR in human lung cancer cellsQ36946749
Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulationQ36965134
BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic InhibitionQ36973111
The molecular and clinical verification of therapeutic resistance via the p38 MAPK-Hsp27 axis in lung cancerQ37046602
BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanomaQ37109564
The complexity of mitogen-activated protein kinases (MAPKs) made simpleQ37230945
Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cellsQ37260512
Epigenetic Reprogramming in CancerQ37291110
In vivo MAPK reporting reveals the heterogeneity in tumoral selection of resistance to RAF inhibitorsQ37365693
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibitionQ37626175
Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition.Q37644414
Pathological roles of MAPK signaling pathways in human diseasesQ37676393
RETRACTED ARTICLE: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagyQ37702749
Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancerQ37715399
Roles of p38 MAPKs in invasion and metastasisQ37977166
Computational approaches for analyzing information flow in biological networksQ38003247
Tumor adaptation and resistance to RAF inhibitorsQ38160738
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectneoplasmQ1216998
drug resistanceQ12147416
MAP kinase signaling systemQ71130435
P577publication date2020-02-07
P13046publication type of scholarly workreview articleQ7318358
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleTargeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
P478volume21

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