| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M701071200 |
| P698 | PubMed publication ID | 17360712 |
| P50 | author | Hugh Christian Watkins | Q5930325 |
| P2093 | author name string | Paul Robinson | |
| Elena Kremneva | |||
| Steven Marston | |||
| Mohammed El-Mezgueldi | |||
| Charles Redwood | |||
| Olga Nikolaeva | |||
| Mahmooda Mirza | |||
| Dimitry Levitsky | |||
| O'neal Copeland | |||
| P2860 | cites work | Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy | Q24290985 |
| Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype | Q24304085 | ||
| Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy | Q24314590 | ||
| Deciphering the design of the tropomyosin molecule | Q27632998 | ||
| The structure of the carboxyl terminus of striated alpha-tropomyosin in solution reveals an unusual parallel arrangement of interacting alpha-helices | Q27640325 | ||
| ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL | Q27861036 | ||
| Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy | Q28139470 | ||
| Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy | Q28198707 | ||
| Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament | Q28255352 | ||
| Thermal unfolding of smooth muscle and nonmuscle tropomyosin alpha-homodimers with alternatively spliced exons | Q28576855 | ||
| Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin | Q34188103 | ||
| Tropomyosin: a new asymmetric protein component of the muscle fibril | Q39420149 | ||
| Separation of subfragment-1 isoenzymes from rabbit skeletal muscle myosin | Q39741645 | ||
| Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit. | Q42606576 | ||
| Regulatory properties of tropomyosin effects of length, isoform, and N-terminal sequence | Q42651874 | ||
| Cooperativity and switching within the three-state model of muscle regulation. | Q42690203 | ||
| Differential regulation of the actomyosin interaction by skeletal and cardiac troponin isoforms. | Q42690345 | ||
| A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: evidence that tropomyosin and troponin increase force in single thin filaments | Q42997459 | ||
| Ca2+-induced rolling of tropomyosin in muscle thin filaments: the alpha- and beta-band hypothesis revisited | Q44728813 | ||
| The muscle thin filament as a classical cooperative/allosteric regulatory system | Q48769623 | ||
| Cooperative inhibition of actin filaments in the absence of tropomyosin. | Q51053097 | ||
| Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin. | Q51389950 | ||
| The 14-fold periodicity in alpha-tropomyosin and the interaction with actin. | Q52851499 | ||
| Characterization of the equilibrium between blocked and closed states of muscle thin filaments. | Q54014357 | ||
| Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility. | Q54561766 | ||
| Effect of Hypertrophic Cardiomyopathy Mutations in Human Cardiac Muscle α -tropomyosin (Asp175Asn and Glu180Gly) on the Regulatory Properties of Human Cardiac Troponin Determined by in vitro Motility Assay | Q57279235 | ||
| P433 | issue | 18 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | dilated cardiomyopathy | Q283656 |
| familial dilated cardiomyopathy | Q56013812 | ||
| P304 | page(s) | 13487-13497 | |
| P577 | publication date | 2007-03-13 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments. | |
| P478 | volume | 282 |
| Q38108764 | A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium |
| Q38134256 | Alpha-tropomyosin mutations in inherited cardiomyopathies |
| Q37264422 | An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity |
| Q27315223 | Arrhythmia caused by a Drosophila tropomyosin mutation is revealed using a novel optical coherence tomography instrument |
| Q42730557 | Conserved noncanonical residue Gly-126 confers instability to the middle part of the tropomyosin molecule. |
| Q34450885 | DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges. |
| Q81107472 | Defective regulation of contractile function in muscle fibres carrying an E41K beta-tropomyosin mutation |
| Q24308001 | Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity |
| Q51308664 | Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle. |
| Q64963237 | Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics. |
| Q38321122 | Effects of non-catalytic, distal amino acid residues on activity of E. coli DinB (DNA polymerase IV). |
| Q28287994 | Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity |
| Q90173602 | Functional outcomes of structural peculiarities of striated muscle tropomyosin |
| Q47254208 | Functional role of the core gap in the middle part of tropomyosin |
| Q53416334 | HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. |
| Q81462180 | How does genotype define phenotype? Microphysiology of a tropomyosin mutation in situ shows the limitations of reductionism |
| Q22061743 | Impaired tropomyosin–troponin interactions reduce activation of the actin thin filament |
| Q28727222 | Integrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosin |
| Q51664761 | Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation. |
| Q42473760 | Investigation of a transgenic mouse model of familial dilated cardiomyopathy. |
| Q51180607 | Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy. |
| Q38184402 | Maladaptive modifications in myofilament proteins and triggers in the progression to heart failure and sudden death |
| Q35172648 | Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. |
| Q35144972 | Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse |
| Q39785961 | Molecular mechanisms of sarcomere dysfunction in dilated and hypertrophic cardiomyopathy |
| Q33768442 | Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K. |
| Q41949346 | Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity. |
| Q30438108 | Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unit |
| Q46953119 | Role of caldesmon in the Ca2+ regulation of smooth muscle thin filaments: evidence for a cooperative switching mechanism |
| Q34608346 | Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin. |
| Q47378513 | Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H. |
| Q91597359 | Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1. |
| Q28307606 | Thin filament mutations: developing an integrative approach to a complex disorder |
| Q37198630 | Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction. |
| Q38186601 | Tropomyosin dynamics |
| Q36982376 | Use of 2-D DIGE analysis reveals altered phosphorylation in a tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy |
| Q38998926 | Using baculovirus/insect cell expressed recombinant actin to study the molecular pathogenesis of HCM caused by actin mutation A331P |
| Q42022510 | Why is it important to analyze the cardiac sarcomere subproteome? |
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