| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1051566328 |
| P356 | DOI | 10.1007/S10974-013-9358-5 |
| P698 | PubMed publication ID | 24005378 |
| P2093 | author name string | Paul Robinson | |
| Charles Redwood | |||
| P2860 | cites work | Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis | Q24290682 |
| Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy | Q24290985 | ||
| Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype | Q24304085 | ||
| Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity | Q24308001 | ||
| Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy | Q24314590 | ||
| Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere | Q24316399 | ||
| Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T | Q27650626 | ||
| Structure of the Rigor Actin-Tropomyosin-Myosin Complex | Q27670842 | ||
| Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy | Q28198707 | ||
| Vertebrate tropomyosin: distribution, properties and function | Q28216589 | ||
| Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy | Q28236892 | ||
| Sarcomere gene mutations in isolated left ventricular noncompaction cardiomyopathy do not predict clinical phenotype | Q28236991 | ||
| What is the role of tropomyosin in the regulation of muscle contraction? | Q28243862 | ||
| A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation | Q28258622 | ||
| Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy | Q28275501 | ||
| Shared genetic causes of cardiac hypertrophy in children and adults | Q28276100 | ||
| Gene mutations in apical hypertrophic cardiomyopathy | Q28280136 | ||
| Mutations in sarcomere protein genes in left ventricular noncompaction | Q28281620 | ||
| Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations | Q28287468 | ||
| Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity | Q28287994 | ||
| Tropomyosin de-phosphorylation in the heart: what are the consequences? | Q28293301 | ||
| Regulation of contraction in striated muscle | Q28610114 | ||
| Regulation of cardiac hypertrophy by intracellular signalling pathways | Q29615166 | ||
| Targeted amino-terminal acetylation of recombinant proteins in E. coli | Q33784412 | ||
| Hypertrophic cardiomyopathy: a systematic review | Q34117625 | ||
| Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β. | Q34162142 | ||
| Contractile dysfunction in hypertrophic cardiomyopathy: elucidating primary defects of mutant contractile proteins by gene transfer | Q34175630 | ||
| Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins | Q64378861 | ||
| Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant alpha-tropomyosins in adult cardiac myocytes | Q64381152 | ||
| Sequence repeats in α-tropomyosin | Q67341520 | ||
| Phosphorylation of tropomyosin in live frog muscle | Q67561795 | ||
| Novel missense mutation in alpha-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy | Q70792037 | ||
| Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility | Q73756846 | ||
| A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice | Q74626036 | ||
| Mechanism of acute mechanical benefit from VDD pacing in hypertrophied heart: similarity of responses in hypertrophic cardiomyopathy and hypertensive heart disease | Q77066258 | ||
| Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction | Q77986125 | ||
| A novel TPM1 mutation in a family with hypertrophic cardiomyopathy and sudden cardiac death in childhood | Q78493649 | ||
| Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy | Q82658704 | ||
| The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle | Q82879726 | ||
| Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle | Q83536107 | ||
| The effect of the dilated cardiomyopathy-causing mutation Glu54Lys of alpha-tropomyosin on actin-myosin interactions during the ATPase cycle | Q84330956 | ||
| The effect of the dilated cardiomyopathy-causing Glu40Lys TPM1 mutation on actin-myosin interactions during the ATPase cycle | Q84528298 | ||
| Identification of a novel TPM1 mutation in a family with left ventricular noncompaction and sudden death | Q85237807 | ||
| A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding | Q85419617 | ||
| Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin | Q34188103 | ||
| Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy | Q34399188 | ||
| DCM-related tropomyosin mutants E40K/E54K over-inhibit the actomyosin interaction and lead to a decrease in the number of cycling cross-bridges. | Q34450885 | ||
| Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations | Q34568089 | ||
| Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. | Q34568719 | ||
| Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion | Q35113389 | ||
| The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy | Q36143822 | ||
| Tropomyosin dephosphorylation results in compensated cardiac hypertrophy | Q36492849 | ||
| Genetic mutations and mechanisms in dilated cardiomyopathy | Q36497170 | ||
| Use of thin filament reconstituted muscle fibres to probe the mechanism of force generation. | Q36565792 | ||
| Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene | Q36833594 | ||
| Genetic testing for dilated cardiomyopathy in clinical practice | Q36882310 | ||
| Decreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathy | Q37213860 | ||
| Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? | Q37834124 | ||
| How do mutations in contractile proteins cause the primary familial cardiomyopathies? | Q37855688 | ||
| Functional alpha-tropomyosin produced in Escherichia coli. A dipeptide extension can substitute the amino-terminal acetyl group | Q38309278 | ||
| Rapid detection of genetic variants in hypertrophic cardiomyopathy by custom DNA resequencing array in clinical practice | Q39793333 | ||
| Thin filament-mediated regulation of cardiac contraction | Q41117735 | ||
| Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia. | Q41896456 | ||
| Ca2+ buffering in the heart: Ca2+ binding to and activation of cardiac myofibrils. | Q41918986 | ||
| Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin | Q42173536 | ||
| Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin | Q42727154 | ||
| α-Tropomyosin with a D175N or E180G mutation in only one chain differs from tropomyosin with mutations in both chains | Q43092360 | ||
| Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade | Q44095817 | ||
| Ca2+-induced rolling of tropomyosin in muscle thin filaments: the alpha- and beta-band hypothesis revisited | Q44728813 | ||
| alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways | Q44805483 | ||
| Physiological significance of troponin T binding domains in striated muscle tropomyosin | Q44932362 | ||
| Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy | Q46557269 | ||
| Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments | Q46954266 | ||
| Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy | Q47759938 | ||
| Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin (TPM1) gene in familial hypertrophic cardiomyopathy | Q48020405 | ||
| Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin. | Q51389950 | ||
| Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle. | Q51816671 | ||
| The 14-fold periodicity in alpha-tropomyosin and the interaction with actin. | Q52851499 | ||
| Novel mutation in the alpha-tropomyosin gene and transition from hypertrophic to hypocontractile dilated cardiomyopathy. | Q52968696 | ||
| The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments. | Q54445230 | ||
| A child cohort study from southern Italy enlarges the genetic spectrum of hypertrophic cardiomyopathy. | Q54470458 | ||
| Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility. | Q54561766 | ||
| Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function. | Q54567660 | ||
| Inherited Cardiomyopathies | Q56384883 | ||
| Effect of Hypertrophic Cardiomyopathy Mutations in Human Cardiac Muscle α -tropomyosin (Asp175Asn and Glu180Gly) on the Regulatory Properties of Human Cardiac Troponin Determined by in vitro Motility Assay | Q57279235 | ||
| A Mutant Tropomyosin That Causes Hypertrophic Cardiomyopathy Is Expressed In Vivo and Associated With an Increased Calcium Sensitivity | Q57279249 | ||
| Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience | Q57316356 | ||
| The Importance of Genetic Counseling, DNA Diagnostics, and Cardiologic Family Screening in Left Ventricular Noncompaction Cardiomyopathy | Q57364826 | ||
| P433 | issue | 3-4 | |
| P304 | page(s) | 285-294 | |
| P577 | publication date | 2013-08-01 | |
| P1433 | published in | Journal of Muscle Research & Cell Motility | Q13739445 |
| P1476 | title | Alpha-tropomyosin mutations in inherited cardiomyopathies | |
| P478 | volume | 34 |
| Q90237180 | A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics |
| Q30839458 | Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice |
| Q34031117 | An atomic model of the tropomyosin cable on F-actin |
| Q28066435 | Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype |
| Q38853345 | Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice |
| Q64963237 | Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics. |
| Q27334908 | Energy landscapes reveal the myopathic effects of tropomyosin mutations |
| Q93137582 | Evaluation of cardiac hypertrophy in the setting of sudden cardiac death |
| Q47254208 | Functional role of the core gap in the middle part of tropomyosin |
| Q64280641 | Functional significance of HCM mutants of tropomyosin, V95A and D175N, studied with motility assays |
| Q44288700 | Introducing a special edition of the Journal of Muscle Research and Cell Motility on tropomyosin: form and function |
| Q51664761 | Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation. |
| Q35172648 | Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. |
| Q47705176 | Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region |
| Q38184400 | Myofilament dysfunction as an emerging mechanism of volume overload heart failure |
| Q37367932 | Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling |
| Q91314949 | Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction |
| Q34608346 | Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin. |
| Q47378513 | Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H. |
| Q38205172 | The myosin-activated thin filament regulatory state, M⁻-open: a link to hypertrophic cardiomyopathy (HCM). |
| Q91597359 | Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1. |
| Q33717809 | Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects |
| Q39094600 | Tropomyosin Structure, Function, and Interactions: A Dynamic Regulator |
| Q42001691 | Tropomyosin movement on F-actin during muscle activation explained by energy landscapes |
| Q36275252 | Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma |
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