| scholarly article | Q13442814 |
| P50 | author | Lucie Carrier | Q28595187 |
| Jolanda van der Velden | Q28595192 | ||
| Folkert J ten Cate | Q42828798 | ||
| Carolyn Ho | Q48604633 | ||
| P2093 | author name string | Anne M Murphy | |
| Corrado Poggesi | |||
| E Rosalie Witjas-Paalberends | |||
| Paul J M Wijnker | |||
| Vasco Sequeira | |||
| Sakthivel Sadayappan | |||
| Aref Najafi | |||
| Cris Dos Remedios | |||
| D Brian Foster | |||
| Diederik W D Kuster | |||
| Ger J M Stienen | |||
| Jessica A Regan | |||
| Louise L A M Nijenkamp | |||
| Marjon A van Slegtenhorst | |||
| Michelle Michels | |||
| Nicky Boontje | |||
| Ruud Zaremba | |||
| Tjeerd Germans | |||
| P2860 | cites work | Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation | Q80340057 |
| Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I | Q82796150 | ||
| Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy | Q24291970 | ||
| Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form | Q24306847 | ||
| Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T | Q27650626 | ||
| Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy | Q28198707 | ||
| Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy | Q28236892 | ||
| Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction | Q28237729 | ||
| Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament | Q28255352 | ||
| Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function | Q28255692 | ||
| Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice | Q28263306 | ||
| GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication | Q28282353 | ||
| Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice | Q28288922 | ||
| Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties | Q28289247 | ||
| Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function | Q28290449 | ||
| Thin filament mutations: developing an integrative approach to a complex disorder | Q28307606 | ||
| Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T | Q28590907 | ||
| Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart | Q30049005 | ||
| Effects of a cardiomyopathy-causing troponin t mutation on thin filament function and structure. | Q30328020 | ||
| Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unit | Q30438108 | ||
| Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy | Q30480164 | ||
| Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene. | Q31722329 | ||
| How do hypertrophic cardiomyopathy mutations affect myocardial function in carriers with normal wall thickness? Assessment with cardiovascular magnetic resonance. | Q33741738 | ||
| Myofilament length dependent activation | Q33787650 | ||
| Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy | Q33978845 | ||
| Tissue Doppler imaging consistently detects myocardial contraction and relaxation abnormalities, irrespective of cardiac hypertrophy, in a transgenic rabbit model of human hypertrophic cardiomyopathy | Q34008230 | ||
| Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults | Q34058337 | ||
| Tropomyosin ends determine the stability and functionality of overlap and troponin T complexes | Q34181125 | ||
| Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy | Q34195823 | ||
| High resolution melting: improvements in the genetic diagnosis of hypertrophic cardiomyopathy in a Portuguese cohort | Q34201881 | ||
| Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C | Q34368485 | ||
| Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy | Q34386835 | ||
| More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease. | Q34420272 | ||
| Myosin head orientation: a structural determinant for the Frank-Starling relationship | Q35056950 | ||
| The N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filament | Q36207947 | ||
| Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoform | Q36235612 | ||
| Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes | Q36369925 | ||
| Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes | Q36528069 | ||
| Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants | Q36743165 | ||
| Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy | Q36828757 | ||
| Myocardial infarction in mice alters sarcomeric function via post-translational protein modification | Q36860519 | ||
| O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function | Q37040657 | ||
| Ala scanning of the inhibitory region of cardiac troponin I. | Q37339001 | ||
| cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance. | Q37956980 | ||
| Cardiac myosin binding protein C phosphorylation in cardiac disease. | Q37962818 | ||
| Single particle analysis of relaxed and activated muscle thin filaments. | Q38447830 | ||
| The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity. | Q38454523 | ||
| Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. | Q38458847 | ||
| The cellular basis of the length-tension relation in cardiac muscle | Q39830305 | ||
| Removal of tropomyosin overlap modifies cooperative binding of myosin S-1 to reconstituted thin filaments of rabbit striated muscle | Q41309166 | ||
| Structural basis for Ca2+-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin | Q41626993 | ||
| Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C). | Q41836341 | ||
| Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia. | Q41896456 | ||
| Structure and orientation of troponin in the thin filament | Q43123353 | ||
| Effects of phosphorylation and mutation R145G on human cardiac troponin I function. | Q43809968 | ||
| Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing | Q44300159 | ||
| Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling. | Q44324598 | ||
| Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility | Q46745076 | ||
| Characterization of the equilibrium between blocked and closed states of muscle thin filaments. | Q54014357 | ||
| Steric-model for activation of muscle thin filaments 1 1 Edited by P.E. Wright | Q58052724 | ||
| Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies | Q58087788 | ||
| Effect of length and cross-bridge attachment on Ca2+ binding to cardiac troponin C | Q70033641 | ||
| Separation and characterization of the two functional regions of troponin involved in muscle thin filament regulation | Q70782795 | ||
| Effect of ionic strength on length-dependent Ca(2+) activation in skinned cardiac muscle | Q73367665 | ||
| Length dependence of Ca(2+)-tension relationship in aequorin-injected ferret papillary muscles | Q73757474 | ||
| Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I | Q74097767 | ||
| Cross-bridge kinetics in rat myocardium: effect of sarcomere length and calcium activation | Q74103856 | ||
| A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice | Q74626036 | ||
| Mechanism of acute mechanical benefit from VDD pacing in hypertrophied heart: similarity of responses in hypertrophic cardiomyopathy and hypertensive heart disease | Q77066258 | ||
| Protein kinase A-mediated acceleration of the stretch activation response in murine skinned myocardium is eliminated by ablation of cMyBP-C | Q80264868 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hypertrophic cardiomyopathy | Q1364270 |
| P304 | page(s) | 1491-505 | |
| P577 | publication date | 2013-05-24 | |
| P1433 | published in | Circulation Research | Q2599020 |
| P1476 | title | Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations | |
| P478 | volume | 112 |
| Q64068696 | A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection |
| Q36394188 | ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease. |
| Q47141059 | Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes |
| Q38134256 | Alpha-tropomyosin mutations in inherited cardiomyopathies |
| Q34277909 | Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathy |
| Q58699044 | Altered Ca and Na Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis |
| Q36579173 | Cardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent Activation |
| Q36444026 | Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation. |
| Q28066435 | Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype |
| Q38584470 | Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology |
| Q38163334 | Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships |
| Q26858986 | Cardiac thin filament regulation and the Frank-Starling mechanism |
| Q47170506 | Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy |
| Q64971291 | Cardiomyopathies and Related Changes in Contractility of Human Heart Muscle. |
| Q57095885 | Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca sensitivity |
| Q38775917 | Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue |
| Q37629210 | Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy |
| Q42119619 | Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. |
| Q34088867 | Differences in the regulation of RyR2 from human, sheep, and rat by Ca²⁺ and Mg²⁺ in the cytoplasm and in the lumen of the sarcoplasmic reticulum |
| Q41957734 | Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle |
| Q47655251 | Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium |
| Q41815143 | ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study). |
| Q64284619 | Extra energy for hearts with a genetic defect: ENERGY trial |
| Q34430364 | FHL2 expression and variants in hypertrophic cardiomyopathy |
| Q35048381 | Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I* |
| Q42592709 | Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput? |
| Q58087435 | Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation |
| Q52662539 | Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy. |
| Q51446174 | Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. |
| Q33903336 | Genotype-specific pathogenic effects in human dilated cardiomyopathy. |
| Q38184398 | Heart failure in congenital heart disease: the role of genes and hemodynamics |
| Q55399715 | High Fibroblast Growth Factor 23 concentrations in experimental renal failure impair calcium handling in cardiomyocytes. |
| Q39310653 | Historical perspective on heart function: the Frank-Starling Law. |
| Q52371503 | Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits. |
| Q42515078 | Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy |
| Q49923294 | Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle |
| Q42877248 | Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies |
| Q36200058 | In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene |
| Q33707376 | Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes |
| Q34080849 | Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy |
| Q36563967 | LRRC10 is required to maintain cardiac function in response to pressure overload. |
| Q55410018 | Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium. |
| Q50850267 | Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24. |
| Q28308168 | Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation |
| Q34608313 | Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation |
| Q42320941 | Life-long tailoring of management for patients with hypertrophic cardiomyopathy : Awareness and decision-making in changing scenarios. |
| Q39138183 | Linking myofilaments to sudden cardiac death: recent advances. |
| Q28242903 | Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy |
| Q41013371 | MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. |
| Q38184402 | Maladaptive modifications in myofilament proteins and triggers in the progression to heart failure and sudden death |
| Q89829948 | Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations |
| Q42622003 | Mechanical aberrations in hypetrophic cardiomyopathy: emerging concepts |
| Q92012621 | Metabolic Alterations in Inherited Cardiomyopathies |
| Q61651710 | Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology |
| Q28255887 | Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes |
| Q37696227 | Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation? |
| Q101224925 | Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes |
| Q27314792 | Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy. |
| Q44354566 | Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy |
| Q37009456 | Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation |
| Q38895391 | Myocardial energy depletion and dynamic systolic dysfunction in hypertrophic cardiomyopathy. |
| Q92948948 | Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy |
| Q41710182 | Myosin filament activation in the heart is tuned to the mechanical task. |
| Q46650156 | Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity |
| Q41627235 | Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models. |
| Q38265757 | Pathomechanisms in heart failure: the contractile connection. |
| Q28087567 | Pathophysiological concepts in the congenital myopathies: blurring the boundaries, sharpening the focus |
| Q89046157 | Phenotyping cardiomyopathy in adult zebrafish |
| Q28239800 | Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes |
| Q45894311 | Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations |
| Q91710630 | Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis |
| Q61800649 | Proposed mechanism for the length dependence of the force developed in maximally activated muscles |
| Q92027205 | Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy |
| Q36339414 | Rapid large-scale purification of myofilament proteins using a cleavable His6-tag |
| Q96304601 | Regulation of Myofilament Contractile Function in Human Donor and Failing Hearts |
| Q46149450 | Relationship of cardiac troponin to systolic global longitudinal strain in hypertrophic cardiomyopathy. |
| Q34219487 | Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations |
| Q27694507 | Research priorities in sarcomeric cardiomyopathies |
| Q42380685 | Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres |
| Q26800070 | Role of Imaging in the Evaluation of Patients at Risk for Sudden Cardiac Death: Genotype-Phenotype Intersection |
| Q34626001 | Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy |
| Q40042653 | Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model. |
| Q51128798 | Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice. |
| Q28607749 | Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs |
| Q39389993 | The Frank-Starling Law: a jigsaw of titin proportions |
| Q47687870 | The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform |
| Q88528489 | The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration |
| Q90711478 | The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM |
| Q36646689 | Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins |
| Q34302767 | Troponin I phosphorylation in human myocardium in health and disease. |
| Q28304882 | Ubiquitin-proteasome system and hereditary cardiomyopathies |
| Q36998382 | Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate |
| Q38743378 | Untangling the Biology of Genetic Cardiomyopathies with Pluripotent Stem Cell Disease Models |
| Q28079573 | Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations? |
| Q38722030 | β-adrenergic receptor signalling and its functional consequences in the diseased heart. |
Search more.