The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration

scientific article published on 27 May 2018

The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1113/JP275579
P698PubMed publication ID29714038

P50authorIrene PerticiQ86131876
Vincenzo LombardiQ88528484
Ger StienenQ42651829
Marco CaremaniQ51648938
Marco LinariQ58943541
Massimo ReconditiQ58943555
Gabriella PiazzesiQ60973154
P2093author name stringFrancesca Pinzauti
Theyencheri Narayanan
P2860cites workChanges in force and cytosolic Ca2+ concentration after length changes in isolated rat ventricular trabeculaeQ74271488
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Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effectorQ27320554
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Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Q33654696
Detyrosinated microtubules buckle and bear load in contracting cardiomyocytesQ33719770
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Is the cross-bridge stiffness proportional to tension during muscle fiber activation?Q33880365
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Stiffness and fraction of Myosin motors responsible for active force in permeabilized muscle fibers from rabbit psoasQ35781242
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Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Q36444026
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Comparison between the sarcomere length-force relations of intact and skinned trabeculae from rat right ventricle. Influence of calcium concentrations on these relationsQ36476237
Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteinsQ36646689
Size and speed of the working stroke of cardiac myosin in situQ36770707
Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor functionQ37068634
The effect of myofilament compliance on kinetics of force generation by myosin motors in muscle.Q37277031
Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filamentsQ37682309
Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseasesQ37701056
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The stiffness of skeletal muscle in isometric contraction and rigor: the fraction of myosin heads bound to actinQ40120574
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Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including manQ42455774
Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle.Q43070024
Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human heartsQ44071888
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Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacingQ44300159
Myosin from failing and non-failing human ventricles exhibit similar contractile propertiesQ44353360
Characterization of radial force and radial stiffness in Ca(2+)-activated skinned fibres of the rabbit psoas muscleQ44646341
Age-dependent changes in contraction and regional myocardial myosin heavy chain isoform expression in ratsQ44954078
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Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke sizeQ47260737
Mechanical and kinetic properties of β-cardiac/slow skeletal muscle myosinQ47322365
Mechanical parameters of the molecular motor myosin II determined in permeabilised fibres from slow and fast skeletal muscles of the rabbit.Q48048732
Minimum number of myosin motors accounting for shortening velocity under zero load in skeletal muscle.Q48053831
Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24.Q50850267
The non-linear elasticity of the muscle sarcomere and the compliance of myosin motors.Q51132298
Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments.Q51648911
Fraction of myosin heads bound to thin filaments in rigor fibrils from insect flight and vertebrate musclesQ59068567
Tension development and sarcomere length in rat cardiac trabeculae. Evidence of length-dependent activationQ71156313
Effects of calcium on the sarcomere length-tension relation in rat cardiac muscle. Implications for the Frank-Starling mechanismQ71294302
Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitroQ71888375
The relation between stiffness and filament overlap in stimulated frog muscle fibresQ72093308
All myosin heads form bonds with actin in rigor rabbit skeletal muscleQ72424233
Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardiumQ73112836
P433issue13
P304page(s)2581-2596
P577publication date2018-05-27
P1433published inJournal of PhysiologyQ7743612
P1476titleThe force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration
P478volume596

Reverse relations

cites work (P2860)
Q64264646A short history of the development of mathematical models of cardiac mechanics
Q90577227Force-Dependent Recruitment from the Myosin Off State Contributes to Length-Dependent Activation
Q60919762Inotropic interventions do not change the resting state of myosin motors during cardiac diastole
Q90711446Myosin filament-based regulation of the dynamics of contraction in heart muscle
Q97418201Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
Q55385445Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task.

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