Expression of the Mammalian Target of Rapamycin Pathway Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma

scientific article published on January 27, 2012

Expression of the Mammalian Target of Rapamycin Pathway Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1159/000334340
P953full work available online athttps://www.karger.com/Article/Pdf/334340
P698PubMed publication ID22286903

P2093author name stringHyun-Soo Kim
Gou Young Kim
Sung-Jig Lim
Youn Wha Kim
P2860cites workActivation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutationsQ43179588
PTEN expression in breast and endometrial cancer: correlations with steroid hormone receptor statusQ43901794
Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancerQ44735709
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesionsQ44968631
Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomasQ46194088
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.Q46708758
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosisQ47680928
PTEN mutations in gliomas and glioneuronal tumors.Q47995275
Higher pAkt expression predicts a significant worse prognosis in glioblastomasQ48228324
Prognostic and predictive values of pERK1/2 and pAkt-1 expression in non-small cell lung cancer patients treated with adjuvant chemotherapy.Q54632156
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.Q27824772
TOR signaling in growth and metabolismQ27860757
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancersQ28145813
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinomaQ28303718
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AktQ29547767
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathwaysQ31837554
Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitorsQ33385120
Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumorsQ34010378
mTOR-targeted therapy of cancer with rapamycin derivativesQ34397003
Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancerQ34616626
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breastQ35788322
Targeting the molecular target of rapamycin (mTOR).Q35997230
mTOR and cancer: reason for dancing at the crossroads?Q36344439
Cancer statistics in Korea: incidence, mortality and survival in 2005.Q37418027
Activation of the mTOR signaling pathway in breast cancer and its correlation with the clinicopathologic variablesQ38504589
Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumorsQ40205287
Significance of Akt phosphorylation on tumor growth and vascular endothelial growth factor expression in human gastric carcinomaQ40265342
Determinants of rapamycin sensitivity in breast cancer cellsQ40590648
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancerQ42660087
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectsirolimusQ32089
adenocarcinomaQ356033
P304page(s)84-93
P577publication date2012-01-27
P1433published inPathobiologyQ2948036
P1476titleExpression of the Mammalian Target of Rapamycin Pathway Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma
P478volume79

Reverse relations

cites work (P2860)
Q49181173Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells
Q33633647Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis
Q83974502Reduced N-Myc downstream-regulated gene 2 expression is associated with CD24 upregulation and poor prognosis in patients with lung adenocarcinoma
Q53226241Sirolimus use and cancer incidence among US kidney transplant recipients
Q64269604The Prognostic Role of Ribosomal Protein S6 Kinase 1 Pathway in Patients With Solid Tumors: A Meta-Analysis

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