Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

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Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00125-006-0497-8
P698PubMed publication ID17160673
P5875ResearchGate publication ID6638430

P2093author name stringF Y Ma
B J Rollins
G H Tesch
D J Nikolic-Paterson
E Ozols
F Y Chow
P2860cites workChronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activitiesQ28513582
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityQ29614283
IKK-beta links inflammation to obesity-induced insulin resistanceQ29614285
CCR2 modulates inflammatory and metabolic effects of high-fat feedingQ29622869
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistanceQ33997240
Diabetic kidney disease in thedb/dbmouseQ34195384
Monocyte chemoattractant protein 1 in obesity and insulin resistanceQ35163496
Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) miceQ36375621
Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient miceQ36400287
Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growthQ37380502
Regulation of nitric oxide production by murine peritoneal macrophages treated in vitro with chemokine monocyte chemoattractant protein 1.Q40765518
Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.Q41165230
Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.Q42804854
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscleQ43759228
In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathwayQ44024701
Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathyQ44265195
ACE inhibitors improve diabetic nephropathy through suppression of renal MCP-1.Q44526996
Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injuryQ44692955
Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosisQ45170289
Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db miceQ46460973
Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazoneQ46620643
Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated miceQ46865455
Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy.Q51554738
Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.Q52566078
Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.Q54223604
Chemokines control fat accumulation and leptin secretion by cultured human adipocytesQ57076426
The role of macrophages in diabetic glomerulosclerosisQ70704470
Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in miceQ73400431
Macrophage accumulation at a site of renal inflammation is dependent on the M-CSF/c-fms pathwayQ74770030
Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritisQ78656070
Production and release of macrophage migration inhibitory factor from human adipocytesQ81089261
P433issue2
P921main subjectobesityQ12174
type 2 diabetesQ3025883
inflammationQ101991
P304page(s)471-480
P577publication date2006-12-12
P1433published inDiabetologiaQ5270140
P1476titleMonocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.
P478volume50

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cites work (P2860)
Q3432455325-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study
Q90307901ALPK1 regulates streptozotocin-induced nephropathy through CCL2 and CCL5 expressions
Q36352141Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy
Q42641988Activation of peroxisome proliferator-activated receptor delta inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice
Q50522405An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes.
Q47733423Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice
Q43876702Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse
Q48395232Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.
Q39009713Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases.
Q36666878Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics
Q54651740Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response
Q35558662BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses
Q89584780Beneficial Effects of Qingzixiaoban Granule on Henoch-Schönlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation
Q50089749Beneficial Effects of n-3 Fatty Acids on Cardiometabolic and Inflammatory Markers in Type 2 Diabetes Mellitus: A Clinical Trial
Q33620560C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria
Q42945868CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice
Q33816616CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice
Q40791151Chemokine expression in renal ischemia/reperfusion injury is most profound during the reparative phase
Q38495475Colchicine attenuates inflammatory cell infiltration and extracellular matrix accumulation in diabetic nephropathy.
Q35141424Combined effect of hyperfiltration and renin angiotensin system activation on development of chronic kidney disease in diabetic db/db mice
Q43174450Critical role for osteopontin in diabetic nephropathy
Q41854992Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy.
Q61512392Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes
Q39370127Detection of adiponectin and monocyte chemoattractant protein-1 using a calixcrown derivatives-coated protein chip
Q34387952Diabetic nephropathy - complications and treatment
Q36589609Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis
Q38810830Dietary low-fat soy milk powder retards diabetic nephropathy progression via inhibition of renal fibrosis and renal inflammation.
Q41652967Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis
Q41854872Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease.
Q37155484Effect of Regular Exercise on the Histochemical Changes of d-Galactose-Induced Oxidative Renal Injury in High-Fat Diet-Fed Rats
Q26825467Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases
Q37684896Emerging roles of hematopoietic cells in the pathobiology of diabetic complications
Q30482887Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet
Q50058406Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy
Q61648712Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice
Q41858296Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy
Q50903298High association of IL-4 gene intron 3 VNTR polymorphism with diabetic peripheral neuropathy.
Q38936622Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets
Q36645971Implications of treatment that target protective mechanisms against diabetic nephropathy
Q99579043In silico prediction and validation of potential therapeutic genes in pancreatic β-cells associated with type 2 diabetes
Q35821566Induction of hemeoxygenase-1 reduces renal oxidative stress and inflammation in diabetic spontaneously hypertensive rats
Q41880267Induction of oxidative stress in kidney
Q26866480Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets
Q35904102Inflammation and oxidative stress in obesity-related glomerulopathy
Q47305480Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets.
Q38042593Inflammation in diabetic nephropathy
Q38255902Inflammation in diabetic nephropathy: moving toward clinical biomarkers and targets for treatment.
Q37871339Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy.
Q39496640Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice
Q41788971Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.
Q91259809Macrophages: versatile players in renal inflammation and fibrosis
Q33699810Mechanisms of inflammatory responses in obese adipose tissue
Q39801451Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy.
Q35439302Metformin suppresses pancreatic tumor growth with inhibition of NFκB/STAT3 inflammatory signaling
Q38692630MicroRNA-29b inhibits diabetic nephropathy in db/db mice
Q80558926Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy
Q50956817Mixed compared with single-source proteins in high-protein diets affect kidney structure and function differentially in obese fa/fa Zucker rats.
Q36222092Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes
Q85225771Monocyte chemoattractant protein-1 (MCP-1) 2518G/A gene polymorphism in Turkish type 2 diabetes patients with nephropathy
Q38140956Monocyte chemoattractant protein-1 -2518G/A gene polymorphism and the risk of nephropathy in type 2 diabetes mellitus among Asians: a meta-analysis
Q41506750Mori cortex prevents kidney damage through inhibiting expression of inflammatory factors in the glomerulus in streptozocin-induced diabetic rats
Q42253708Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy.
Q43049709Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression.
Q34836376Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy
Q64945155Novel Immunomodulatory Cytokine Regulates Inflammation, Diabetes, and Obesity to Protect From Diabetic Nephropathy.
Q38265818Novel effective drugs for diabetic kidney disease? or not?
Q33742301Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats
Q38298806Obesity-associated mouse adipose stem cell secretion of monocyte chemotactic protein-1.
Q84742870Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin-angiotensin-aldosterone system inhibition
Q47321983Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose‑treated HK‑2 cells
Q43286010Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
Q43196259Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.
Q37819453Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy
Q36666799Reduced albuminuria with sarpogrelate is accompanied by a decrease in monocyte chemoattractant protein-1 levels in type 2 diabetes
Q92824810Reduction in Urinary Chemokine (C-C Motif) Ligand 2 (CCL2) After Surgery-Induced Weight Loss
Q38842693Renoprotective effect of a combination of garlic and telmisartan against ischemia/reperfusion-induced kidney injury in obese rats
Q82270824Renoprotective effects of clarithromycin via reduction of urinary MCP-1 levels in type 2 diabetic patients
Q33963259Resveratrol increases nephrin and podocin expression and alleviates renal damage in rats fed a high-fat diet
Q38359435Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.
Q36863519Role of MCP-1 on inflammatory processes and metabolic dysfunction following high-fat feedings in the FVB/N strain
Q54782198Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.
Q88035415Role of the Immune System in Diabetic Kidney Disease
Q35048727SUMOylation of PPARγ by rosiglitazone prevents LPS-induced NCoR degradation mediating down regulation of chemokines expression in renal proximal tubular cells
Q46979190Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells.
Q37174513Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.
Q36731626Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor γ agonist improve vascular function and decrease renal injury in hypertensive obese rats
Q87462719Switching to multiple daily injection therapy with glulisine improves glycaemic control, vascular damage and treatment satisfaction in basal insulin glargine-injected diabetic patients
Q37798716Systemic effects of white adipose tissue dysregulation and obesity-related inflammation
Q26852726Targeting inflammation in diabetes: Newer therapeutic options
Q38144642The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation.
Q49499359The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy
Q34603718The therapeutic role of monocyte chemoattractant protein-1 in a renal tissue engineering strategy for diabetic patients
Q35079607Therapeutic targets for treating fibrotic kidney diseases
Q35720839Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy
Q64325743Tumour necrosis factor-related apoptosis-inducing ligand expression in patients with diabetic nephropathy
Q90216471Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα

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