Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance.

scientific article

Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.24232
P698PubMed publication ID21520171
P5875ResearchGate publication ID51077103

P50authorIrene Oi-lin NgQ67487913
P2093author name stringJoyce Man-Fong Lee
Karen Man-Fong Sze
Glanice Kin-Yan Chu
Tai-On Yau
Kris Lai-Ting Wong
P2860cites workMicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologueQ24643939
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stabilityQ33706377
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activityQ33774967
beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance.Q34302259
Regulation of PTEN by Rho small GTPasesQ34406790
Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissuesQ36179908
Tenets of PTEN tumor suppressionQ37154214
PRL1 promotes cell migration and invasion by increasing MMP2 and MMP9 expression through Src and ERK1/2 pathwaysQ37395771
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.Q37594844
Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidneyQ38359975
Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cellsQ39822190
Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migrationQ39845007
Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cellsQ40126795
PPARgamma activator rosiglitazone inhibits cell migration via upregulation of PTEN in human hepatocarcinoma cell line BEL-7404.Q40267742
Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway.Q40274284
Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1.Q40278801
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potentialQ40558090
The alteration of PTEN tumor suppressor expression and its association with the histopathological features of human primary hepatocellular carcinomaQ40596882
Establishment of cell lines from a primary hepatocellular carcinoma and its metastatisQ42798888
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinomaQ43049041
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.Q43621579
Activation of PPARgamma increases PTEN expression in pancreatic cancer cellsQ44283207
The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinasesQ45408836
Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9.Q46126230
PTEN/MMAC1 mutations in hepatocellular carcinomasQ48203168
The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells.Q52573380
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1Q57184595
Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activationQ73194343
Expression and significance of new tumor suppressor gene PTEN in primary liver cancerQ73437715
Molecular pathogenesis of hepatocellular carcinomaQ80172406
Treatment of hepatocellular carcinomaQ81502350
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)1558-1569
P577publication date2011-05-01
P1433published inHepatologyQ15724398
P1476titleLoss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance
P478volume53

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cites work (P2860)
Q36644350A Targetable Molecular Chaperone Hsp27 Confers Aggressiveness in Hepatocellular Carcinoma
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Q36546768Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway
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