| scholarly article | Q13442814 |
| P356 | DOI | 10.1006/ABBI.1993.1401 |
| P698 | PubMed publication ID | 8342945 |
| P50 | author | Elizabeth M. Gillam | Q63088924 |
| P2093 | author name string | Baba T | |
| Guengerich FP | |||
| Ohmori S | |||
| Kim BR | |||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Escherichia coli | Q25419 |
| P304 | page(s) | 123-131 | |
| P577 | publication date | 1993-08-01 | |
| P1433 | published in | Archives of Biochemistry and Biophysics | Q635818 |
| P1476 | title | Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme | |
| P478 | volume | 305 |
| Q34342947 | 1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes. |
| Q47937263 | 7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites |
| Q35580887 | Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysis |
| Q33224655 | Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis |
| Q46601389 | Anionic phospholipid-induced regulation of reactive oxygen species production by human cytochrome P450 2E1. |
| Q35554802 | Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. |
| Q74497640 | Bacterial expression of two human aryl sulfotransferases |
| Q42066742 | CO binding kinetics of human cytochrome P450 3A4. Specific interaction of substrates with kinetically distinguishable conformers. |
| Q33891038 | CYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus |
| Q88763523 | CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712 |
| Q30985116 | Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase |
| Q54576819 | Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli. |
| Q38675000 | Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate |
| Q58035710 | Cooperativity in Cytochrome P450 3A4 |
| Q36598930 | Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5). |
| Q24298673 | Crystal structure of human cytochrome P450 2D6 |
| Q41135778 | Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase. |
| Q43513492 | Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones |
| Q33900892 | Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. Catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate |
| Q33912074 | Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid. |
| Q39243009 | Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes |
| Q40948757 | Cytochrome P450 proteins and potential utilization in biodegradation |
| Q34551011 | Defining CYP3A4 structural responses to substrate binding. Raman spectroscopic studies of a nanodisc-incorporated mammalian cytochrome P450. |
| Q50118326 | Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108. |
| Q48712941 | Differential inducibility of specific mRNA corresponding to five CYP3A isoforms in female rat liver by RU486 and food deprivation: comparison with protein abundance and enzymic activities. |
| Q37330641 | Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether |
| Q34383431 | Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli |
| Q38781487 | Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4. |
| Q53572387 | Effects of N-terminal modification of recombinant human cytochrome P450 1A2 on catalytic activity. |
| Q46859251 | Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers |
| Q35608108 | Effects of membrane mimetics on cytochrome P450-cytochrome b5 interactions characterized by NMR spectroscopy. |
| Q36446785 | Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes |
| Q34951334 | Engineered yeasts simulating P450-dependent metabolisms: tricks, myths and reality. |
| Q59443728 | Engineering highly functional thermostable proteins using ancestral sequence reconstruction |
| Q51157184 | Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego. |
| Q36611878 | Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide |
| Q77747864 | Expression, purification, and spectroscopic characterization of human thromboxane synthase |
| Q34036767 | Facile production of minor metabolites for drug development using a CYP3A shuffled library |
| Q54567842 | Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11. |
| Q42233562 | Functional reconstitution of monomeric CYP3A4 with multiple cytochrome P450 reductase molecules in Nanodiscs |
| Q55055040 | Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization. |
| Q77158068 | High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli |
| Q36724323 | Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase |
| Q42929087 | Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function |
| Q59153222 | Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers |
| Q51467454 | Human, rat and crocodile liver microsomal monooxygenase activities measured using diazepam and nifedipine: effects of CYP3A inhibitors and relationship to immunochemically detected CYP3A apoprotein. |
| Q45996870 | Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase. |
| Q43960740 | In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids |
| Q44492695 | In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s |
| Q24296409 | Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation |
| Q46560552 | Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers. |
| Q37216568 | Inhibition of Human Cytochrome P450 2c8-catalyzed Amodiaquine N-desethylation: Effect of Five Traditionally and Commonly Used Herbs |
| Q34998005 | Inhibition of human cytochrome P450 3A4 by cholesterol |
| Q24293148 | Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes |
| Q42428773 | Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer |
| Q33802460 | Isocyanides inhibit human heme oxygenases at the verdoheme stage |
| Q46935182 | Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. |
| Q41904468 | Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. |
| Q54578311 | Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. |
| Q57447560 | Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes |
| Q34710847 | Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4. |
| Q41101001 | Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli |
| Q41045769 | Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. |
| Q34575026 | Mechanism-based inactivation of human cytochrome P450 3A4 by two piperazine-containing compounds |
| Q42429132 | Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs |
| Q45965531 | Membrane integration of recombinant human P450 forms. |
| Q33639797 | Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison. |
| Q50120819 | Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase. |
| Q46906291 | Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series |
| Q36520398 | Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids |
| Q48000536 | Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification. |
| Q77366605 | Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein |
| Q24796562 | Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs |
| Q38393619 | Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4 |
| Q54984248 | Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses. |
| Q41188301 | New applications of bacterial systems to problems in toxicology. |
| Q44741178 | Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9. |
| Q43783052 | Oxidation of N,N-dimethylformamide and N,N-diethylformamide by human liver microsomes and human recombinant P450s |
| Q41785690 | Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13 |
| Q36926122 | Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine |
| Q41034255 | Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes |
| Q51278611 | Production of ω-hydroxy palmitic acid using CYP153A35 and comparison of cytochrome P450 electron transfer system in vivo. |
| Q73021372 | Purification and characterization of the hepatic CYP2C and 3A isozymes from phenobarbitone pretreated rhesus monkey |
| Q50140928 | Purification of functional recombinant P450s from bacteria. |
| Q40574839 | Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group. |
| Q34529849 | Recent Structural Insights into Cytochrome P450 Function |
| Q50048298 | Recombinant Production of Eukaryotic Cytochrome P450s in microbial cell factories. |
| Q24309389 | Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1 |
| Q38354366 | Regioselective hydroxylation of steroid hormones by human cytochromes P450. |
| Q34975426 | Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy |
| Q35231748 | Simultaneous measurement of CYP1A2 activity, regioselectivity, and coupling: Implications for environmental sensitivity of enzyme-substrate binding |
| Q35776638 | Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals |
| Q43645369 | Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase |
| Q33538232 | Strategies to enhance the coexpression of cytochrome P450 2E1 and reductase in bacteria |
| Q90198868 | Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability |
| Q28577087 | Structure-function relationships of rat liver CYP3A9 to its human liver orthologs: site-directed active site mutagenesis to a progesterone dihydroxylase |
| Q44433649 | Studies on the Interactions between Drug and Estrogen. II. On the Inhibitory Effect of 29 Drugs Reported to Induce Gynecomastia on the Oxidation of Estradiol at C-2 or C-17 |
| Q40927959 | Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systems |
| Q24607331 | Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase |
| Q43106337 | Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations |
| Q58035715 | The Ferrous-Dioxygen Intermediate in Human Cytochrome P450 3A4 |
| Q58035712 | The One-electron Autoxidation of Human Cytochrome P450 3A4 |
| Q34082998 | The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil |
| Q37308650 | The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. |
| Q36565026 | Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli |
| Q73815753 | Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions |
| Q33898260 | Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. |
| Q36412665 | mRNA distribution and heterologous expression of orphan cytochrome P450 20A1 |
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