Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson's Disease Penetrance.

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Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson's Disease Penetrance. is …
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scholarly articleQ13442814

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P356DOI10.1155/2018/8684906
P932PMC publication ID5863306
P698PubMed publication ID29707191

P50authorIrene PichlerQ30347710
Andrew A HicksQ37389840
P2093author name stringPeter P Pramstaller
Alessandra Zanon
P2860cites workFamilial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutationQ73187402
An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical productionQ73192853
Sequence analysis of the entire mitochondrial genome in Parkinson's diseaseQ77577390
Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controlsQ88257756
Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaQ21563375
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesisQ22242250
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's diseaseQ24294809
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityQ24296955
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Q24297155
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyQ24300975
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1Q24301357
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagyQ24316726
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsQ24322788
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagyQ24339224
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.Q24634577
Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic StressQ27305291
Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's diseaseQ27686808
Sequence and organization of the human mitochondrial genomeQ27860659
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing studyQ28114901
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality controlQ28114972
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkleQ28235835
Mitochondrial dysfunction and oxidative damage in parkin-deficient miceQ28593859
Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent MitophagyQ29147504
Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson DiseaseQ29398392
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkinQ29547423
Mitochondrial respiratory-chain diseasesQ29614474
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by ParkinQ29615623
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusinQ29615625
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsQ29615627
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinQ29615684
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson diseaseQ29619113
PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkinQ29622838
Epidemiology, environmental risk factors and genetics of Parkinson's disease.Q30238483
Genetics of Parkinson's disease.Q30241723
Postencephalitic parkinsonism--a reviewQ30432015
A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2Q30497782
Environment, mitochondria, and Parkinson's diseaseQ34133031
PINK1 mutations are associated with sporadic early-onset parkinsonismQ34345883
A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's diseaseQ34526685
Mitochondrial DNA: impacting central and peripheral nervous systemsQ34737643
Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanismsQ34864555
Gut microbiota are related to Parkinson's disease and clinical phenotypeQ35492461
Respiratory chain enzyme activities in lymphocytes from untreated patients with Parkinson diseaseQ72964832
SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and DrosophilaQ47928029
Point mutations of mitochondrial genome in Parkinson's diseaseQ48075275
Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondriaQ48333081
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neuronsQ48588748
Mitochondrial DNA polymorphism in substantia nigraQ48844431
CHCHD2 gene mutations in familial and sporadic Parkinson's diseaseQ49100971
Early-onset familial parkinsonism due to POLG mutationsQ50278596
A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathyQ50493784
Microbe-mitochondrion crosstalk and health: An emerging paradigmQ51801047
Mitochondrial DNA sequence analysis of four Alzheimer's and Parkinson's disease patientsQ53321449
Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's diseaseQ64796856
Epidemiology of Parkinson's disease.Q67401761
Deficiencies in complex I subunits of the respiratory chain in Parkinson's diseaseQ69356679
Abnormalities of the electron transport chain in idiopathic Parkinson's diseaseQ69361952
???Q64787295
The role of environmental exposures in neurodegeneration and neurodegenerative diseasesQ35551001
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neuronsQ35611727
Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons.Q35852144
Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivoQ35912064
Elevated serum pesticide levels and risk of Parkinson diseaseQ36060169
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's DiseaseQ36212145
Somatic mtDNA variation is an important component of Parkinson's diseaseQ36595656
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brainQ36727241
Deciphering the role of heterozygous mutations in genes associated with parkinsonismQ36854642
Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson diseaseQ37027318
Mitochondria in the aetiology and pathogenesis of Parkinson's diseaseQ37037953
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial traffickingQ37219276
Effects of the organochlorine pesticide methoxychlor on dopamine metabolites and transporters in the mouse brain.Q37401337
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson diseaseQ37434427
Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brainsQ37623036
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicityQ37683630
Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neuronsQ37715032
A tale on animal models of Parkinson's diseaseQ37882583
What genetics tells us about the causes and mechanisms of Parkinson's diseaseQ37947563
Neurotoxin-based models of Parkinson's diseaseQ37959729
Mechanism of the neurotoxicity of MPTP. An updateQ38005808
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequencesQ38021865
Parkinsonism, cognitive deficit and behavioural disturbance caused by a novel mutation in the polymerase gamma geneQ38365994
Of Pesticides and Men: a California Story of Genes and Environment in Parkinson's DiseaseQ38726592
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's DiseaseQ38746811
Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiomeQ38962543
Mutations of glucocerebrosidase gene and susceptibility to Parkinson's disease: An updated meta-analysis in a European populationQ40914689
Mitochondrial complex I deficiency in Parkinson's diseaseQ41821730
PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.Q42321011
Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in ratsQ42436464
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.Q45161551
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes.Q45963658
Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's diseaseQ46691979
Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylationQ46715278
Parkinsonism associated with the homozygous W748S mutation in the POLG1 gene.Q46717380
Pooled analysis of tobacco use and risk of Parkinson diseaseQ46785257
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.Q47823702
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectParkinson's diseaseQ11085
P304page(s)8684906
P577publication date2018-03-07
P1433published inParkinson's diseaseQ27723341
P1476titleEnvironmental and Genetic Variables Influencing Mitochondrial Health and Parkinson's Disease Penetrance.
P478volume2018

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cites work (P2860)
Q90121106Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases
Q61809108Potential Role of Mic60/Mitofilin in Parkinson's Disease
Q57026122Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes

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