Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.

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Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer. is …
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scholarly articleQ13442814

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P356DOI10.1038/S41598-018-24755-8
P932PMC publication ID5928241
P698PubMed publication ID29712937

P50authorBenjamin G BarwickQ57039490
Hao FengQ88408821
Elizabeth KennedyQ88524510
Zhentian LiQ88524512
William DynanQ88524515
Paula VertinoQ88524517
P2093author name stringD R Powell
J Kowalski
K N Conneely
B Dwivedi
J S K Bell
M R McCrary
P2860cites workDouble strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG islandQ21092482
Bioconductor: open software development for computational biology and bioinformaticsQ21194861
An integrated encyclopedia of DNA elements in the human genomeQ22122150
The 15-country collaborative study of cancer risk among radiation workers in the nuclear industry: estimates of radiation-related cancer risksQ23912278
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG IslandsQ24297794
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shoresQ24649374
The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine OxidationsQ26824713
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1Q27651995
Role of TET enzymes in DNA methylation, development, and cancerQ28068541
Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beingsQ28237254
Functions of DNA methylation: islands, start sites, gene bodies and beyondQ29547260
Integrative analysis of 111 reference human epigenomesQ29615565
Solid cancer incidence in atomic bomb survivors: 1958-1998Q29620810
Short- and long-term effects of (56)Fe irradiation on cognition and hippocampal DNA methylation and gene expression.Q30826360
Space radiation risks for astronauts on multiple International Space Station missionsQ31159280
Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.Q33606592
Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects ModelsQ33687771
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genesQ33742114
Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung.Q33907138
Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancerQ34153828
CpGassoc: an R function for analysis of DNA methylation microarray dataQ34208767
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteinsQ34377284
Modulation of the DNA-damage response to HZE particles by shielding.Q39955124
Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific mannerQ40016096
Microarray analysis of promoter methylation in lung cancers.Q40325370
Late-occurring chromosome aberrations and global DNA methylation in hematopoietic stem/progenitor cells of CBA/CaJ mice exposed to silicon ((28)Si) ionsQ40510770
Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ miceQ41614571
Densely ionizing radiation affects DNA methylation of selective LINE-1 elements.Q41640839
Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expressionQ42831643
Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.Q43121080
Calculation of the energy deposition in nanovolumes by protons and HZE particles: geometric patterns of initial distributions of DNA repair fociQ44558515
Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changesQ44974933
High LET (56)Fe ion irradiation induces tissue-specific changes in DNA methylation in the mouseQ45214127
Updates to astronaut radiation limits: radiation risks for never-smokersQ45374657
Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition: analyzing DNA methylation of transcriptional enhancers reveals missed regulatory links between cancer risk loci and genesQ46241160
The methylation of DNA repeat elements is sex-dependent and temporally different in response to X radiation in radiosensitive and radioresistant mouse strainsQ46950131
Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation.Q47824835
Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation.Q51497663
Heavy ion carcinogenesis and human space exploration.Q53321679
Analyses of the Secondary Particle Radiation and the DNA Damage It Causes to Human KeratinocytesQ58432987
Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ionsQ84288843
Gamma irradiation does not induce detectable changes in DNA methylation directly following exposure of human cellsQ34425083
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.Q34485631
Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) miceQ34651076
Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cellsQ34711034
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencingQ34723852
Distinct transcriptome profiles identified in normal human bronchial epithelial cells after exposure to γ-rays and different elemental particles of high Z and energyQ34750487
Software for computing and annotating genomic rangesQ34945230
Genome-wide screen of DNA methylation changes induced by low dose X-ray radiation in mice.Q35116647
Identification of radiation-induced aberrant hypomethylation in colon cancerQ35127773
DNA methylation status predicts cell type-specific enhancer activity.Q35176962
Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampusQ35977326
Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lungQ36271584
Proton Beams Inhibit Proliferation of Breast Cancer Cells by Altering DNA Methylation StatusQ36563924
ChromHMM: automating chromatin-state discovery and characterizationQ36625108
Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimatesQ36632251
Radiation-induced changes in DNA methylation of repetitive elements in the mouse heartQ36788582
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic primingQ36853522
Enhancer methylation dynamics contribute to cancer plasticity and patient mortalityQ36893810
Induction of Chronic Inflammation and Altered Levels of DNA Hydroxymethylation in Somatic and Germinal Tissues of CBA/CaJ Mice Exposed to (48)Ti IonsQ37039724
Charting a dynamic DNA methylation landscape of the human genomeQ37292011
Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures.Q37450570
Effects of low fluences of radiations found in space on cellular systemsQ37453253
Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancerQ37653607
Epigenetic determinants of space radiation-induced cognitive dysfunctionQ37654846
Aging epigenetics: causes and consequencesQ38024561
Animal studies of charged particle-induced carcinogenesisQ38049102
Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) MiceQ38418655
Bi-directional and shared epigenomic signatures following proton and 56Fe irradiationQ38429129
Relative effectiveness at 1 gy after acute and fractionated exposures of heavy ions with different linear energy transfer for lung tumorigenesisQ38445568
Radiation-induced epigenetic DNA methylation modification of radiation-response pathwaysQ38487760
Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing RadiationQ38662727
Particle Radiation Therapy for Gastrointestinal CancersQ38724284
The effect of radiation quality on genomic DNA methylation profiles in irradiated human cell linesQ39581344
Radiation-induced epigenetic alterations after low and high LET irradiationsQ39620020
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)6709
P577publication date2018-04-30
P1433published inScientific ReportsQ2261792
P1476titleGalactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer
P478volume8

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cites work (P2860)
Q90194223Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications
Q57058967Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure
Q99413898Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations
Q99237760Why Do the Cosmic Rays Induce Aging?

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