Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.

scientific article

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JMCB/MJV050
P932PMC publication ID4937888
P698PubMed publication ID26186941

P50authorHeather O'HaganQ73821325
Stephen B. BaylinQ28113000
P2093author name stringNing Ding
Brooke E Hannon
Emily M Bonham
Thomas R Amick
P2860cites workThe hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cellsQ39487655
DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.Q39531551
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cellsQ40405040
DNA methyltransferase Dnmt1 and mismatch repairQ40513970
Correction of hypermutability, N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6.Q41086058
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery.Q41122376
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutationQ41448577
The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP poolQ44025676
Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis.Q53294599
Noncanonical Mismatch Repair as a Source of Genomic Instability in Human CellsQ63383558
Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templatesQ73854858
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG islandQ21092482
Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1Q22299424
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG IslandsQ24297794
A census of human soluble protein complexesQ24297808
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomasQ24617520
Comprehensive molecular characterization of human colon and rectal cancerQ24630415
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsQ28144364
DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsQ28212826
DNA Repair EnzymesQ28264799
Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesQ28285134
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nucleiQ29616800
Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cellsQ31081839
Recruitment of DNA methyltransferase I to DNA repair sitesQ33217127
Recruitment of mismatch repair proteins to the site of DNA damage in human cellsQ33365884
Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.Q33606592
TET enzymes, TDG and the dynamics of DNA demethylation.Q33715010
Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6.Q33855528
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survivalQ35080450
H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cellsQ36021719
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymesQ36044774
Epigenetics and colorectal cancerQ36081553
Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiationQ36325598
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation productsQ36445449
Classification of colorectal cancer based on correlation of clinical, morphological and molecular featuresQ36699559
Chromatin challenges during DNA replication and repairQ36744476
Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatmentQ36791604
Prime, repair, restore: the active role of chromatin in the DNA damage responseQ38022970
Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.Q38221703
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectDNA mismatch repairQ2984243
DNA damageQ5205747
P304page(s)244-254
P577publication date2015-07-17
P1433published inJournal of Molecular Cell BiologyQ2456339
P1476titleMismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage
P478volume8

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cites work (P2860)
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Q29147555Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer
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Q90477163JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage
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Q33618077Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health?
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