Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.

scientific article published in January 2017

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2016.12.013
P932PMC publication ID5260804
P698PubMed publication ID28107650

P50authorStephen B. BaylinQ28113000
Wenbing XieQ41634154
Jianjun LuoQ56769648
Hariharan EaswaranQ59451799
P2093author name stringZhihong Wang
Yi Cai
Yana Li
Limin Xia
Ray-Whay Chiu Yen
Yang W Zhang
P2860cites workDouble strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG islandQ21092482
Acetylation-dependent regulation of Skp2 functionQ24292805
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG IslandsQ24297794
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2Q24306181
Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidationQ24311603
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Q24316558
Cancer-associated IDH1 mutations produce 2-hydroxyglutarateQ24320239
A decade of exploring the cancer epigenome - biological and translational implicationsQ24614467
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
Histone H3K27ac separates active from poised enhancers and predicts developmental stateQ24628758
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNAQ24632387
IDH1 and IDH2 mutations in gliomasQ24648948
Inflammation and cancerQ24649640
Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNAQ27681187
Histone deacetylases and cancerQ28240447
The epigenomics of cancerQ28289975
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specificationQ28504641
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiationQ29615366
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
Proteomics. Tissue-based map of the human proteomeQ29617248
Mutation in TET2 in myeloid cancersQ29619292
TET enzymes, TDG and the dynamics of DNA demethylation.Q33715010
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylationQ34258768
Role of Tet proteins in enhancer activity and telomere elongationQ34271341
The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformationQ34355585
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage.Q34485631
Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylationQ34954115
Acquired mutations in TET2 are common in myelodysplastic syndromesQ34984094
oxBS-450K: a method for analysing hydroxymethylation using 450K BeadChips.Q35007310
CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenasesQ35007645
TET proteins and the control of cytosine demethylation in cancerQ35021377
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesisQ35575250
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutationsQ35624365
DNA methylation: TET proteins-guardians of CpG islands?Q35634706
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.Q35640316
A DNA hypermethylation module for the stem/progenitor cell signature of cancer.Q35914847
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylationQ36008141
Acute loss of TET function results in aggressive myeloid cancer in miceQ36360635
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.Q36659158
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX.Q36815200
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic primingQ36853522
Chronic inflammation and oxidative stress in human carcinogenesisQ36950970
Oxidative stress, DNA methylation and carcinogenesis.Q37121227
TETonic shift: biological roles of TET proteins in DNA demethylation and transcriptionQ37244379
Reversing DNA methylation: mechanisms, genomics, and biological functionsQ37609689
Interplay between the cancer genome and epigenomeQ38094260
5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability.Q38795786
5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiationQ38952550
Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).Q41610545
Regulation of TET protein stability by calpains.Q42998566
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectDNA methylationQ874745
P304page(s)323-335
P577publication date2017-01-01
P1433published inMolecular CellQ3319468
P1476titleAcetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress
P478volume65

Reverse relations

cites work (P2860)
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Q99207639Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
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