Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice.

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Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice. is …
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scholarly articleQ13442814

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P356DOI10.1155/2018/5463879
P932PMC publication ID5832131
P698PubMed publication ID29651443

P50authorChang-Qing XiaQ60987124
Michael J Clare-SalzlerQ88347501
P2093author name stringJeannette Lo
Ruihua Peng
P2860cites workGeneration of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulationQ41215778
Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice.Q41649585
Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trialQ42504585
Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cellsQ42944333
Attenuation of inducible Th2 immunity with autoimmune disease progressionQ43497362
Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD miceQ44062613
1,25-Dihydroxyvitamin D3 alters the profile of bone marrow-derived dendritic cells of NOD miceQ45256436
Re-establishing immune tolerance in type 1 diabetes via regulatory T cells.Q45883089
Infectious Th1 and Th2 autoimmunity in diabetes‐prone miceQ45983475
Homeostatic proliferation of naïve CD8+ T cells depends on CD62L/L-selectin-mediated homing to peripheral LN.Q46156069
The frequency of high avidity T cells determines the hierarchy of determinant spreadingQ46180161
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone miceQ46345979
Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone miceQ46419442
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetesQ46512140
Antigen-based immunotherapy drives the precocious development of autoimmunityQ46626418
GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetesQ47912616
Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)Q33592891
Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic miceQ33649618
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.Q33977505
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcriptionQ34201095
Dendritic cells as a tool to induce anergic and regulatory T cellsQ34295082
IL-7 is essential for homeostatic control of T cell metabolism in vivoQ34307992
A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice.Q34382930
Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reactionQ34479579
DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responsesQ34508459
Immature, but not inactive: the tolerogenic function of immature dendritic cellsQ34842360
Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipientsQ35160185
Prevention of diabetes in nonobese diabetic mice by dendritic cell transferQ35821238
Recent advances in dendritic cell biologyQ36094388
Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetesQ36366434
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cellsQ36371345
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.Q36399104
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity.Q36563563
Type 1 diabetes patients have significantly lower frequency of plasmacytoid dendritic cells in the peripheral bloodQ37014824
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectorsQ37018786
Complications of splenectomyQ37154229
Lymphoid stroma in the initiation and control of immune responses.Q37257010
Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant toleranceQ37353045
Therapy with GAD in diabetesQ37408187
Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.Q37476298
Homeostatic proliferation and survival of naïve and memory T cellsQ37564251
Determinant spreading and the dynamics of the autoimmune T-cell repertoire.Q40487702
Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivoQ40752701
BCG priming of dendritic cells enhances T regulatory and Th1 function and suppresses allergen-induced Th2 function in vitro and in vivoQ52910803
Granulocyte-dendritic cell unbalance in the non-obese diabetic miceQ52953838
Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type I diabetesQ53586176
Qualitative and quantitative abnormalities in splenic dendritic cell populations in NOD miceQ53905372
Defective maturation of myeloid dendritic cell (DC) in NOD mice is controlled by IDD10/17/18.Q53908405
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.Q55066037
Dendritic Cells Transduced to Express Interleukin-4 Prevent Diabetes in Nonobese Diabetic Mice with Advanced InsulitisQ62748513
Phenotypic and Functional Characteristics of BM-Derived DC from NOD and Non-Diabetes-Prone StrainsQ62748597
Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD MiceQ71656099
Peptide therapy for diabetes in NOD miceQ72671513
Immunotherapy of NOD mice with bone marrow-derived dendritic cellsQ73224770
Major histocompatibility complex class I peptide-pulsed host dendritic cells induce antigen-specific acquired thymic tolerance to islet cellsQ73438405
A self MHC class II beta-chain peptide prevents diabetes in nonobese diabetic miceQ73869271
Induction of tolerance by IL-10-treated dendritic cellsQ73873437
Induction of transplant tolerance with immunodominant allopeptide-pulsed host lymphoid and myeloid dendritic cellsQ74415746
The DPT-1 trial: a negative result with lessons for future type 1 diabetes preventionQ74691160
Altered dendritic cells (DC) might be responsible for regulatory T cell imbalance and autoimmunity in nonobese diabetic (NOD) miceQ77948340
Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient miceQ79316172
Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin studyQ80510733
Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cellsQ80597339
Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3.LuciDTR miceQ82555014
Lowered expressions of the NF-kappaB family members in dendritic cells from NOD mice are associated with a reduced expression of GATA-2Q83140347
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectdendritic cellQ506253
P304page(s)5463879
P577publication date2018-02-14
P1433published inJournal of Immunology ResearchQ26841936
P1476titleImmature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice
P478volume2018

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cites work (P2860)
Q90190141Induction of Antitumor Immunity by Exosomes Isolated from Cryopreserved Cord Blood Monocyte-Derived Dendritic Cells
Q64268733Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?
Q61798675Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy