review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Frank P Shewmaker | |
Shannon N Rhoads | |||
Debra S Yee | |||
Zachary T Monahan | |||
P2860 | cites work | Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass | Q24299250 |
Identification, analysis, and prediction of protein ubiquitination sites | Q24624622 | ||
Systematic and quantitative assessment of the ubiquitin-modified proteome | Q24634631 | ||
A new subtype of frontotemporal lobar degeneration with FUS pathology | Q24647697 | ||
State of play in amyotrophic lateral sclerosis genetics | Q26864816 | ||
Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1. | Q27301265 | ||
Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease | Q27316174 | ||
Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts | Q27319837 | ||
Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation | Q27325625 | ||
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q28131672 | ||
Getting Access to Low-Complexity Domain Modifications. | Q51710732 | ||
The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice. | Q52168068 | ||
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. | Q52537887 | ||
TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation. | Q53280316 | ||
Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles. | Q53305315 | ||
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. | Q53368534 | ||
Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. | Q55042791 | ||
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome | Q55920728 | ||
TDP-43 and FUS: a nuclear affair | Q84433614 | ||
Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis | Q39054098 | ||
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation | Q39078089 | ||
ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. | Q39150934 | ||
RNA-binding proteins with prion-like domains in health and disease | Q39227676 | ||
Toward a comprehensive characterization of a human cancer cell phosphoproteome. | Q39237219 | ||
Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies. | Q39349822 | ||
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response | Q39378487 | ||
BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS) proteolysis through a protein kinase CbetaII-dependent pathway | Q39454928 | ||
Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations | Q39464446 | ||
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation | Q39575648 | ||
Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling | Q39618479 | ||
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations | Q39627330 | ||
Studies of phosphoproteomic changes induced by nucleophosmin-anaplastic lymphoma kinase (ALK) highlight deregulation of tumor necrosis factor (TNF)/Fas/TNF-related apoptosis-induced ligand signaling pathway in ALK-positive anaplastic large cell lymp | Q39714603 | ||
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions | Q39811057 | ||
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis | Q39927199 | ||
Identification and characterization of FUS/TLS as a new target of ATM. | Q39962311 | ||
Phosphorylation of C-terminal tyrosine residue 526 in FUS impairs its nuclear import. | Q40505707 | ||
Special focus on the Cajal Body | Q41072570 | ||
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons. | Q41469956 | ||
Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells | Q41839212 | ||
Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics | Q42013412 | ||
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43) | Q42110964 | ||
Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. | Q42114854 | ||
Tau phosphorylation affects its axonal transport and degradation | Q42160128 | ||
Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules | Q42208957 | ||
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. | Q42378053 | ||
Neuronal cytoplasmic inclusions in tau, TDP-43, and FUS molecular subtypes of frontotemporal lobar degeneration share similar spatial patterns | Q42516406 | ||
Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome. | Q44209738 | ||
Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions | Q46686145 | ||
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs. | Q47137715 | ||
Proteome-Level Analysis Indicates Global Mechanisms for Post-Translational Regulation of RRM Domains | Q47340947 | ||
Liquid phase condensation in cell physiology and disease | Q47649585 | ||
Germline P granules are liquid droplets that localize by controlled dissolution/condensation | Q47748097 | ||
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains | Q47752760 | ||
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation. | Q47844024 | ||
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing | Q50037033 | ||
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites | Q28140445 | ||
Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode | Q28205934 | ||
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis | Q28236796 | ||
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 | Q28236805 | ||
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC | Q28241075 | ||
TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling | Q28246694 | ||
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles | Q28247080 | ||
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations | Q28254001 | ||
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells | Q28267574 | ||
FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS | Q28484269 | ||
Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines | Q28552267 | ||
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization | Q28588090 | ||
A curated compendium of phosphorylation motifs | Q29029867 | ||
Protein arginine methylation in mammals: who, what, and why | Q29617309 | ||
Kinesin transports RNA: isolation and characterization of an RNA-transporting granule | Q29618417 | ||
Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells | Q30002318 | ||
Proteomic Analysis of Arginine Methylation Sites in Human Cells Reveals Dynamic Regulation During Transcriptional Arrest | Q30002366 | ||
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts | Q30458567 | ||
FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress | Q30577079 | ||
Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains | Q30577537 | ||
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions | Q30661910 | ||
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). | Q30663823 | ||
In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling | Q33598027 | ||
FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage | Q33707858 | ||
Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration | Q33830991 | ||
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS | Q33889532 | ||
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. | Q33928657 | ||
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis | Q34118590 | ||
Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms. | Q34155410 | ||
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. | Q34232143 | ||
Functions of FUS/TLS from DNA repair to stress response: implications for ALS. | Q34305789 | ||
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules | Q34308339 | ||
Coexisting Liquid Phases Underlie Nucleolar Subcompartments | Q34527840 | ||
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice | Q34662602 | ||
The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules | Q37379010 | ||
Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence. | Q37388956 | ||
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects | Q37609639 | ||
Integrated proteomic analysis of post-translational modifications by serial enrichment. | Q37618636 | ||
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration | Q37733168 | ||
Amyloids and yeast prion biology | Q38078949 | ||
Global phosphoproteomic profiling reveals distinct signatures in B-cell non-Hodgkin lymphomas | Q38433704 | ||
Protein Methyltransferases: A Distinct, Diverse, and Dynamic Family of Enzymes | Q38664608 | ||
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43. | Q38803419 | ||
Treatment with a Global Methyltransferase Inhibitor Induces the Intranuclear Aggregation of ALS-Linked FUS Mutant In Vitro | Q38816949 | ||
Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling | Q38962630 | ||
TDP-43/FUS in motor neuron disease: Complexity and challenges. | Q38969736 | ||
Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder | Q39006704 | ||
Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo | Q34689011 | ||
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes | Q34694194 | ||
The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage | Q34801900 | ||
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. | Q34992138 | ||
Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics | Q35311600 | ||
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. | Q35587208 | ||
ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism | Q35605176 | ||
A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells | Q35692123 | ||
The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease | Q35800000 | ||
FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP | Q35865531 | ||
LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration | Q35898177 | ||
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements | Q35924992 | ||
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. | Q35928701 | ||
Tau phosphorylation in neuronal cell function and dysfunction | Q35945517 | ||
ALS mutations in TLS/FUS disrupt target gene expression | Q36032446 | ||
Proteogenomics connects somatic mutations to signalling in breast cancer | Q36037203 | ||
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins | Q36172705 | ||
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II | Q36172715 | ||
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function | Q36320469 | ||
A method for large-scale identification of protein arginine methylation | Q36386994 | ||
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. | Q36408540 | ||
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function | Q36548825 | ||
Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics | Q36745154 | ||
Effect of methylation on the side-chain pKa value of arginine | Q36749523 | ||
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology | Q36848271 | ||
Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss | Q36906420 | ||
FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis | Q36922849 | ||
Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants | Q37096949 | ||
Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics | Q37153932 | ||
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity | Q37164410 | ||
The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. | Q37177771 | ||
Motif-specific sampling of phosphoproteomes | Q37243739 | ||
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells | Q37254703 | ||
Prion protein misfolding and disease | Q37373871 | ||
P275 | copyright license | Creative Commons Attribution | Q6905323 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | regulation of gene expression | Q411391 |
nucleoprotein | Q419245 | ||
membrane protein | Q423042 | ||
prion | Q47051 | ||
post-translational protein modification | Q898362 | ||
prion protein family | Q24724413 | ||
proto-oncogene protein | Q66020913 | ||
neoplasm protein | Q66894191 | ||
macromolecular substance | Q75174158 | ||
P577 | publication date | 2018-03-16 | |
P1433 | published in | International Journal of Molecular Sciences | Q3153277 |
P1476 | title | The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS. | |
P478 | volume | 19 |
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Q64251597 | Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases |
Q93020476 | Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation |
Q92500890 | Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes |
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