| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2016NatCo...710465S |
| P356 | DOI | 10.1038/NCOMMS10465 |
| P932 | PMC publication ID | 4742863 |
| P698 | PubMed publication ID | 26842965 |
| P5875 | ResearchGate publication ID | 293015007 |
| P2093 | author name string | Lei Lu | |
| George Z Mentis | |||
| Neil A Shneider | |||
| Aarti Sharma | |||
| Adriana Nemes | |||
| Sara Ebrahimi Nasrabady | |||
| Juan Carlos Tapia | |||
| Monica Mendelsohn | |||
| Alexander K Lyashchenko | |||
| Margot Elmaleh | |||
| P2860 | cites work | Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis. | Q51774971 |
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| Functions of FUS/TLS from DNA repair to stress response: implications for ALS. | Q34305789 | ||
| Activity-dependent FUS dysregulation disrupts synaptic homeostasis | Q34480824 | ||
| TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA | Q34831850 | ||
| Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells | Q35695216 | ||
| Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue | Q35830662 | ||
| Widespread distribution of the major polypeptide component of MAP 1 (microtubule-associated protein 1) in the nervous system | Q36209567 | ||
| Light and electron microscope localization of the microtubule-associated tau protein in rat brain | Q36433582 | ||
| Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons | Q36626479 | ||
| Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs | Q36650975 | ||
| High-contrast en bloc staining of neuronal tissue for field emission scanning electron microscopy | Q36981939 | ||
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| The role of FUS gene variants in neurodegenerative diseases | Q38212812 | ||
| The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. | Q38732625 | ||
| Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis | Q39054098 | ||
| ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. | Q39150934 | ||
| Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies. | Q39349822 | ||
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| Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein | Q40233283 | ||
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| Amyotrophic lateral sclerosis: macro-EMG and twitch forces of single motor units | Q44481993 | ||
| P525L FUS mutation is consistently associated with a severe form of juvenile amyotrophic lateral sclerosis. | Q45894689 | ||
| ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. | Q46135324 | ||
| Differentiation of mouse embryonic stem cells to spinal motor neurons | Q46390435 | ||
| The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. | Q46409672 | ||
| Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. | Q47951637 | ||
| Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis. | Q48021519 | ||
| AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks | Q48337086 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | amyotrophic lateral sclerosis | Q206901 |
| P304 | page(s) | 10465 | |
| P577 | publication date | 2016-02-04 | |
| P1433 | published in | Nature Communications | Q573880 |
| P1476 | title | ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function | |
| P478 | volume | 7 |
| Q50072058 | A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons |
| Q93182322 | A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress |
| Q83230784 | A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the motor system |
| Q92187628 | ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now? |
| Q99547009 | ALS Genetics: Gains, Losses, and Implications for Future Therapies |
| Q58698109 | ALS Yeast Models—Past Success Stories and New Opportunities |
| Q30849444 | ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation |
| Q57813809 | ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS |
| Q96305499 | Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis |
| Q38867229 | Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis |
| Q58621641 | Amyloid assembly and disassembly |
| Q57805709 | Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity |
| Q92242536 | Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis |
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| Q37348694 | Changes in the Expression of FUS/TLS in Spinal Cords of SOD1 G93A Transgenic Mice and Correlation with Motor-Neuron Degeneration. |
| Q30836650 | Characterization of genetic loss-of-function of Fus in zebrafish. |
| Q90428731 | Conditional depletion of Fus in oligodendrocytes leads to motor hyperactivity and increased myelin deposition associated with Akt and cholesterol activation |
| Q47158820 | Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy. |
| Q40207108 | DOK7 gene therapy enhances motor activity and life span in ALS model mice |
| Q47163862 | De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies |
| Q42651961 | Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma |
| Q37072993 | Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. |
| Q37736433 | FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. |
| Q88292829 | FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons |
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| Q47623937 | Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice. |
| Q55215170 | Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS. |
| Q55343691 | Importance of Functional Loss of FUS in FTLD/ALS. |
| Q64096028 | Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death |
| Q55001546 | Linking hnRNP Function to ALS and FTD Pathology. |
| Q47723065 | Liquidizing FUS via prion-like domain phosphorylation |
| Q64078047 | Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons |
| Q90211090 | Low Level of Expression of C-Terminally Truncated Human FUS Causes Extensive Changes in the Spinal Cord Transcriptome of Asymptomatic Transgenic Mice |
| Q26749169 | Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis |
| Q48645659 | Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice |
| Q91982212 | Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| Q47342302 | Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice |
| Q38430493 | Modelling FUS Mislocalisation in an In Vitro Model of Innervated Human Muscle. |
| Q30827515 | Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging |
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| Q30848999 | Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis |
| Q33665800 | Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis |
| Q58751835 | Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis |
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| Q37533026 | Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase. |
| Q39344391 | New routes in frontotemporal dementia drug discovery |
| Q91864259 | Novel small molecule TRVA242 targets neuromuscular junction in amyotrophic lateral sclerosis |
| Q55038139 | Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1. |
| Q47134784 | Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides |
| Q91741049 | Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS) |
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| Q64983354 | Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus. |
| Q42378053 | Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. |
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| Q47569012 | RNA-binding proteins in neurodegeneration: mechanisms in aggregate |
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| Q48228453 | Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis |
| Q38896526 | Role of FET proteins in neurodegenerative disorders |
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| Q38835008 | Stress granules at the intersection of autophagy and ALS. |
| Q64999275 | Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses. |
| Q36336278 | TDP-43 and FUS en route from the nucleus to the cytoplasm |
| Q38969736 | TDP-43/FUS in motor neuron disease: Complexity and challenges. |
| Q91781195 | The Peripheral Nervous System in Amyotrophic Lateral Sclerosis: Opportunities for Translational Research |
| Q55416173 | The Role of Macrophages in Neuroinflammatory and Neurodegenerative Pathways of Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis: Pathogenetic Cellular Effectors and Potential Therapeutic Targets. |
| Q54967377 | The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS. |
| Q28069344 | The bowel and beyond: the enteric nervous system in neurological disorders |
| Q92932176 | The emerging role of minor intron splicing in neurological disorders |
| Q58779202 | The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration |
| Q58806144 | The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization |
| Q61807545 | Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis |
| Q58230740 | Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice |
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| Q92775462 | Uses for humanised mouse models in precision medicine for neurodegenerative disease |
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| Q58700147 | genetically interacts with the ALS-associated orthologue and mediates its toxicity |
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