scholarly article | Q13442814 |
P50 | author | Gen Sobue | Q67219868 |
P2093 | author name string | Shinsuke Ishigaki | |
P2860 | cites work | Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma | Q24309359 |
hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II | Q24562004 | ||
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription | Q24646744 | ||
A new subtype of frontotemporal lobar degeneration with FUS pathology | Q24647697 | ||
State of play in amyotrophic lateral sclerosis genetics | Q26864816 | ||
The function of RNA-binding proteins at the synapse: implications for neurodegeneration | Q26991684 | ||
FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis | Q27339258 | ||
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis | Q28236796 | ||
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 | Q28236805 | ||
TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines | Q28284342 | ||
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders | Q29618148 | ||
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis | Q29619430 | ||
Onset and progression in inherited ALS determined by motor neurons and microglia | Q29619515 | ||
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2. | Q30456334 | ||
Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review | Q33726688 | ||
Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations | Q34099212 | ||
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis | Q34118590 | ||
Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia | Q34125553 | ||
Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions | Q34183099 | ||
Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches. | Q34314477 | ||
Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice. | Q50744118 | ||
Sporadic juvenile amyotrophic lateral sclerosis caused by mutant FUS/TLS: possible association of mental retardation with this mutation. | Q50780775 | ||
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. | Q52537887 | ||
Novel FUS deletion in a patient with juvenile amyotrophic lateral sclerosis. | Q52620592 | ||
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. | Q53368534 | ||
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau. | Q38619152 | ||
The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. | Q38732625 | ||
Dendritic Spine Pathology in Neurodegenerative Diseases | Q38747180 | ||
Position-specific binding of FUS to nascent RNA regulates mRNA length | Q38872764 | ||
Liquid-liquid phase separation in cellular signaling systems | Q38934732 | ||
Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. | Q39095704 | ||
RNA-binding proteins with prion-like domains in health and disease | Q39227676 | ||
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration. | Q39235670 | ||
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations | Q39627330 | ||
Axonal transport defects are a common phenotype in Drosophila models of ALS. | Q39774347 | ||
FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis | Q39927199 | ||
Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA. | Q40070020 | ||
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics | Q40287573 | ||
Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons | Q41644415 | ||
FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization | Q41950782 | ||
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain | Q41955381 | ||
Loss of fused in sarcoma (FUS) promotes pathological Tau splicing | Q42138048 | ||
FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns | Q42146718 | ||
Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions | Q42246467 | ||
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients | Q42261802 | ||
Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. | Q42347699 | ||
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. | Q42378053 | ||
Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies | Q42503599 | ||
TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila | Q43593822 | ||
Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain | Q46245874 | ||
3'UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function | Q47735809 | ||
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains | Q47752760 | ||
Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder. | Q47946104 | ||
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. | Q48338403 | ||
Activity-dependent FUS dysregulation disrupts synaptic homeostasis | Q34480824 | ||
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration | Q34518577 | ||
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice | Q34662602 | ||
ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation | Q35034350 | ||
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. | Q35114564 | ||
Familial behavioral variant frontotemporal dementia associated with astrocyte-predominant tauopathy | Q35196395 | ||
Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease | Q35234889 | ||
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation | Q35869162 | ||
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements | Q35924992 | ||
ALS mutations in TLS/FUS disrupt target gene expression | Q36032446 | ||
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function | Q36320469 | ||
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons | Q36453024 | ||
The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum | Q36485513 | ||
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function | Q36548825 | ||
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. | Q36602121 | ||
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs | Q36650975 | ||
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. | Q36677109 | ||
Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells. | Q36805034 | ||
Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss | Q36906420 | ||
The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei | Q36934790 | ||
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. | Q37072993 | ||
FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. | Q37080289 | ||
The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons | Q37364300 | ||
The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules | Q37379010 | ||
Rethinking ALS: the FUS about TDP-43. | Q37419912 | ||
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects | Q37609639 | ||
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. | Q37736433 | ||
TDP-43 and FUS/TLS: sending a complex message about messenger RNA in amyotrophic lateral sclerosis? | Q37910303 | ||
The changing scene of amyotrophic lateral sclerosis | Q38086771 | ||
FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLD. | Q38131381 | ||
Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q38174758 | ||
The phenotypic variability of amyotrophic lateral sclerosis | Q38259758 | ||
Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS. | Q38314794 | ||
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells. | Q38326803 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P921 | main subject | amyotrophic lateral sclerosis | Q206901 |
P304 | page(s) | 44 | |
P577 | publication date | 2018-05-03 | |
P1433 | published in | Frontiers in molecular biosciences | Q27726420 |
P1476 | title | Importance of Functional Loss of FUS in FTLD/ALS. | |
P478 | volume | 5 |
Q90451856 | Differential subcellular expression of P525LFUS as a putative biomarker for ALS phenoconversion |
Q64096028 | Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death |
Q91946029 | Role of RNA Binding Proteins with prion-like domains in muscle and neuromuscular diseases |
Q64999275 | Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses. |
Q89963639 | The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia |
Q93159410 | Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation |
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