FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons

scientific article published on 03 April 2018

FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BRAINRES.2018.03.037
P932PMC publication ID6347466
P698PubMed publication ID29625118

P2093author name stringThomas E Lloyd
Brian M Woolums
James B Machamer
Gregory G Fuller
P2860cites workThe Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic ParaplegiasQ26738451
Mechanisms of FUS mutations in familial amyotrophic lateral sclerosisQ26749169
Pokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociceptionQ26862727
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degenerationQ27342067
Optimization of a GCaMP Calcium Indicator for Neural Activity ImagingQ27674109
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosisQ28236796
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6Q28236805
Role of axonal transport in neurodegenerative diseasesQ28284096
ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the diseaseQ28392297
Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine headsQ28582163
Dendritic organization in the neurons of the visual and motor cortices of the catQ29616515
Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae.Q30497522
Deficits in axonal transport precede ALS symptoms in vivoQ30497554
Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.Q30511133
The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress responseQ33351073
Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.Q33651150
The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction.Q33784500
Branching out: mechanisms of dendritic arborizationQ34111001
Activity-dependent FUS dysregulation disrupts synaptic homeostasisQ34480824
Male sterility and enhanced radiation sensitivity in TLS(-/-) miceQ34662602
How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?Q57938863
Axonal ion channel dysfunction in amyotrophic lateral sclerosisQ71681845
Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivoQ34689011
Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and diseaseQ34689753
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.Q34882752
Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onsetQ34989403
ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulationQ35034350
Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in DrosophilaQ35288983
The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic terminiQ35965342
Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal NeuronsQ36453024
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesisQ36459963
ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of functionQ36548825
Expression of human FUS protein in Drosophila leads to progressive neurodegenerationQ36584516
Stress granules as crucibles of ALS pathogenesis.Q36804082
Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.Q36805034
Synaptic regulation of microtubule dynamics in dendritic spines by calcium, F-actin, and drebrinQ37231480
Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.Q37534101
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defectsQ37609639
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegenerationQ37733168
The genetics and neuropathology of amyotrophic lateral sclerosisQ38035744
Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS.Q38314794
Visualizing Axons in the Drosophila Central Nervous System Using Immunohistochemistry and Immunofluorescence: Figure 1Q38617419
The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.Q38732625
Overexpression of nuclear FUS induces neuronal cell deathQ38929777
PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.Q39235670
Axonal transport defects are a common phenotype in Drosophila models of ALS.Q39774347
Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stageQ40351989
Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.Q41469956
Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growthQ41739468
Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in DrosophilaQ41758682
FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilizationQ41950782
Drosophila larval NMJ immunohistochemistryQ42058055
Genetic mutations in RNA-binding proteins and their roles in ALS.Q42278719
Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein.Q43028561
Tiling of the Drosophila epidermis by multidendritic sensory neurons.Q45960946
Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidanceQ46045692
FUS toxicity is rescued by the modulation of lncRNA hsrω expression in Drosophila melanogasterQ46068056
Axonal excitability properties in amyotrophic lateral sclerosisQ47202111
Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis.Q48021519
Unraveling Synaptic GCaMP Signals: Differential Excitability and Clearance Mechanisms Underlying Distinct Ca2+ Dynamics in Tonic and Phasic Excitatory, and Aminergic Modulatory Motor Terminals in DrosophilaQ49724117
Motorneurons require cysteine string protein-α to maintain the readily releasable vesicular pool and synaptic vesicle recycling.Q50499095
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.Q52537887
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.Q52607544
P4510describes a project that usesImageJQ1659584
P433issuePt A
P1104number of pages12
P304page(s)55-66
P577publication date2018-04-03
P1433published inBrain ResearchQ4955782
P1476titleFUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons
P478volume1693

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Q58766511as a Model for Assessing the Function of RNA-Binding Proteins during Neurogenesis and Neurological Diseasecites workP2860

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