BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork.

scientific article published in April 2018

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/IOVS.17-23282
P932PMC publication ID5915111
P698PubMed publication ID29801150

P2093author name stringAbbot F Clark
J Cameron Millar
Colleen M McDowell
Humberto Hernandez
Stacy M Curry
P2860cites workIdentification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cellsQ24301259
Signal transduction of bone morphogenetic protein receptorsQ24302298
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathwaysQ24317164
Glaucoma is second leading cause of blindness globallyQ24650287
Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissuesQ28215513
Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cellsQ28575347
Bambi is coexpressed with Bmp-4 during mouse embryogenesisQ28591981
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinaseQ28628494
BAMBI is overexpressed in ovarian cancer and co-translocates with Smads into the nucleus upon TGF-beta treatmentQ39734268
Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesisQ40768961
Biomarkers of primary open-angle glaucomaQ41489091
Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor.Q41675605
Erythrocyte phagocytosis in the human trabecular meshworkQ41838011
Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyesQ41911194
BAMBI inhibits skin fibrosis in keloid through suppressing TGF-β1-induced hypernomic fibroblast cell proliferation and excessive accumulation of collagen I.Q41960935
BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulationQ42466454
AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-betaQ42477189
Dexamethasone inhibition of trabecular meshwork cell phagocytosis and its modulation by glucocorticoid receptor betaQ42604553
Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyesQ42641738
Transforming growth factor-β2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway.Q42788830
Characterization of a spontaneously immortalized bovine trabecular meshwork cell lineQ42822851
Genomic organization and localization of mouse Nma/BAMBI: possible implications related to ameloblastoma formationQ44253985
Particulate phagocytosis by trabecular meshwork endotheliumQ44790656
BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling.Q44803485
Transforming growth factor-beta in human aqueous humorQ44803554
Effect of Nma on growth inhibition by TGF-betaa in human gastric carcinoma cell lines.Q44892684
Kinetics of phagocytosis in trabecular meshwork cells. Flow cytometry and morphometryQ44942196
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.Q45345819
The overexpression of BAMBI and its involvement in the growth and invasion of human osteosarcoma cellsQ45854862
Isolation, culture, and characterization of human fetal trabecular meshwork cellsQ46129832
Strain and Age Effects on Aqueous Humor Dynamics in the MouseQ46676393
TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressureQ46872561
The aqueous levels of TGF-beta2 in patients with glaucomaQ47760506
TLR4 enhances TGF-beta signaling and hepatic fibrosisQ29620016
Effect of transforming growth factor-beta 2 on phagocytosis in cultured bovine trabecular meshwork cellsQ33185779
Ocular localization and transduction by adenoviral vectors are serotype-dependent and can be modified by inclusion of RGD fiber modificationsQ34215308
Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesisQ34321742
Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signalingQ34331767
Bone Morphogenetic Protein (BMP) signaling in development and human diseasesQ34512444
Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteinsQ35221340
Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factorsQ35612446
BAMBI elimination enhances alternative TGF-β signaling and glomerular dysfunction in diabetic miceQ35630822
Toll-like receptors in liver fibrosis: cellular crosstalk and mechanismsQ35977675
Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent SignalingQ35980006
Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork CellsQ36008830
Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cellsQ36073969
A magnetic bead-based method for mouse trabecular meshwork cell isolationQ36135221
Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone.Q36174962
Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in sclerodermaQ36511520
The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand bindingQ36555325
Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in miceQ36730478
Trabecular meshwork phagocytosis in glaucomatous eyesQ36864384
Dexamethasone decreases phagocytosis by human trabecular meshwork cells in situ.Q36881049
LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic HyperplasiaQ36950638
Development of a model of elevated intraocular pressure in rats by gene transfer of bone morphogenetic protein 2.Q37095332
Evidence for a calcification process in the trabecular meshworkQ37163213
Activin signaling as an emerging target for therapeutic interventionsQ37268461
Number of people with glaucoma worldwideQ37320324
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.Q37431653
Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in miceQ37494344
Future target molecules in antiglaucoma therapy: tgf-Beta may have a role to playQ37614805
Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cellsQ37622655
Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular MeshworkQ37731910
The role of TGF-β2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma.Q38187160
Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cellsQ38751158
Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells.Q39131376
Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes.Q39558073
Loss of cell-matrix cohesiveness after phagocytosis by trabecular meshwork cells.Q52509697
Human trabecular meshwork cells express BMP antagonist mRNAs and proteins.Q53786530
Effects of TGF-beta2 in perfused human eyes.Q53850637
Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes.Q53872045
Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes.Q53891879
Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells.Q54560456
Balancing BMP Signaling through Integrated Inputs into the Smad1 LinkerQ60325056
Phagocytosis by trabecular meshwork cells: sequence of events in cats and monkeysQ67979412
Human trabecular meshwork phagocytosis. Observations in an organ culture systemQ68554740
Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferationQ68751224
Effects of gamma-interferon on human trabecular meshwork cell phagocytosisQ70745007
Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2Q72113985
Trabecular cells express the TGF-beta 2 gene and secrete the cytokineQ72716228
[Establishment of in vitro culture of bovine trabecular meshwork cells and their phagocytosis]Q73473252
Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2Q73990987
Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucomaQ79837331
Assessment of Aqueous Humor Dynamics in the Mouse by a Novel Method of Constant-Flow InfusionQ85068101
Expression of BAMBI and its combination with Smad7 correlates with tumor invasion and poor prognosis in gastric cancerQ87725103
BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathwayQ87816074
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)2154-2166
P577publication date2018-04-01
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleBMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork.
P478volume59

Reverse relations

cites work (P2860)
Q96576858Fibronectin extra domain A (FN-EDA) elevates intraocular pressure through Toll-like receptor 4 signaling
Q90308827Inducible rodent models of glaucoma
Q90806509Lycium barbarum polysaccharides alleviate hydrogen peroxide-induced injury by up-regulation of miR-4295 in human trabecular meshwork cells
Q64997525Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review).
Q91173373SPARCL1 promotes C2C12 cell differentiation via BMP7-mediated BMP/TGF-β cell signaling pathway
Q91152001Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells

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