Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum.

scientific article

Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PONE.0197511
P932PMC publication ID5969768
P698PubMed publication ID29799863

P50authorRangeline Azevedo da SilvaQ88812665
Rodrigo JardimQ96035283
P2093author name stringMelise Chaves Silveira
Antonio Basilio de Miranda
Leandro de Mattos Pereira
P2860cites workInitial sequencing and analysis of the human genomeQ21045365
Non-homologous isofunctional enzymes: a systematic analysis of alternative solutions in enzyme evolutionQ21093192
Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinereaQ21563381
Novel biopesticide based on a spider venom peptide shows no adverse effects on honeybeesQ51076776
Importance of pollinators in changing landscapes for world cropsQ52675046
Essential Genes Are More Evolutionarily Conserved Than Are Nonessential Genes in BacteriaQ56783033
Reactive oxygen species signaling in response to pathogensQ57748274
A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunityQ59049221
Non-orthologous gene displacementQ71651862
Phospholipase activity in Cryptococcus neoformans: a new virulence factor?Q73467398
Environmental exposure to pesticides and cancer risk in multiple human organ systemsQ86833287
A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacaoQ22065307
Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of PathogenesisQ22065881
The B73 Maize Genome: Complexity, Diversity, and DynamicsQ22065899
Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000Q22066353
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analysesQ22122085
Comparative genomics reveals mobile pathogenicity chromosomes in FusariumQ22122192
Genome sequence of the palaeopolyploid soybeanQ22122200
Insights into social insects from the genome of the honeybee Apis melliferaQ22122237
Genome sequence of the plant pathogen Ralstonia solanacearumQ22122347
The complete genome sequence of the gram-positive bacterium Bacillus subtilisQ22122360
The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein foldQ24598128
Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycleQ24642876
Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expressionQ24684647
Parenteral exposure to pesticides and occurence of congenital malformations: hospital-based case-control studyQ26779561
SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogenyQ26781958
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triadQ26781998
Acetazolamide-based fungal chitinase inhibitorsQ27665555
SCOP: a structural classification of proteins database for the investigation of sequences and structuresQ27860689
SUPERFAMILY: HMMs representing all proteins of known structure. SCOP sequence searches, alignments and genome assignmentsQ28212954
Self-reported acute pesticide intoxications in EthiopiaQ28384211
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosisQ28486886
Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivityQ28542986
Mutational and Structural Analysis of Conserved Residues in Ribose-5-Phosphate Isomerase B from Leishmania donovani: Role in Substrate Recognition and Conformational StabilityQ28550595
Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structureQ29547343
Distinguishing Homologous from Analogous ProteinsQ29617777
Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and hemeQ30152968
Impact of pesticides use in agriculture: their benefits and hazardsQ30396501
Mutants of Xanthomonas oryzae pv. oryzae deficient in general secretory pathway are virulence deficient and unable to secrete xylanaseQ30855602
Essential genes are more evolutionarily conserved than are nonessential genes in bacteriaQ31066425
Analogous Enzymes: Independent Inventions in Enzyme EvolutionQ32028978
Pesticide exposure and risk of Parkinson's disease: a family-based case-control studyQ33326142
In Silico Prediction of Drug Targets in Phytopathogenic Pseudomonas syringae pv. phaseolicola: Charting a Course for Agrigenomics Translation ResearchQ38493664
Comparative analysis of three indigenous plasmids from Xanthomonas axonopodis pv. glycinesQ38510206
Using bacterial genomes and essential genes for the development of new antibioticsQ39035296
Genome Sequence of Aspergillus flavus NRRL 3357, a Strain That Causes Aflatoxin Contamination of Food and FeedQ39717679
A new G6PD knockdown tumor-cell line with reduced proliferation and increased susceptibility to oxidative stressQ39879809
A plant-inducible gene of Xanthomonas campestris pv. campestris encodes an exocellular component required for growth in the host and hypersensitivity on nonhostsQ39960239
A cytoplasmic Cu-Zn superoxide dismutase SOD1 contributes to hyphal growth and virulence of Fusarium graminearumQ40731715
Pseudomonas syringae pv. tomato OxyR Is Required for Virulence in Tomato and ArabidopsisQ40915735
Convergent evolution of enzyme active sites is not a rare phenomenonQ41447676
Genome update of Botrytis cinerea strains B05.10 and T4.Q41585767
Effect of cyprodinil and fludioxonil pesticides on bovine liver catalase activityQ41786386
Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for TritrypsQ41983355
Draft Whole-Genome Sequence of the Biocontrol Agent Trichoderma harzianum T6776.Q42096083
Sequence of the tomato chloroplast DNA and evolutionary comparison of solanaceous plastid genomesQ42690884
The pentose phosphate pathway and parasitic protozoaQ44085345
A highly conserved effector in Fusarium oxysporum is required for full virulence on ArabidopsisQ44187058
Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta.Q44655603
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome informationQ45213048
Functional Analogy in Human Metabolism: Enzymes with Different Biological Roles or Functional Redundancy?Q47108904
Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosisQ48076355
AnEnPi: identification and annotation of analogous enzymesQ33394033
The constancy of gene conservation across divergent bacterial ordersQ33398138
Divergence and convergence in enzyme evolutionQ34070421
Pesticides as a cause of occupational skin diseases in farmers.Q34293785
The differential expression of multiple isoenzyme forms during stage conversion of Toxoplasma gondii: an adaptive developmental strategyQ34294968
Glycolysis as a target for the design of new anti-trypanosome drugs.Q34341037
Perspectives for new drugs against trypanosomiasis and leishmaniasisQ34522560
Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophagesQ34532068
Comparative genome structure, secondary metabolite, and effector coding capacity across Cochliobolus pathogensQ34565854
The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specializationQ34682180
Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseasesQ34795203
Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatmentQ34968549
Metabolic pathways in the post-genome era.Q35135595
Target validation: linking target and chemical properties to desired product profileQ35237566
Housekeeping enzymes as virulence factors for pathogensQ35648181
Characterization of glutathione transferases involved in the pathogenicity of Alternaria brassicicolaQ35665462
Integrative conjugative elements of the ICEPan family play a potential role in Pantoea ananatis ecological diversification and antibiosisQ35692026
Systematic characterization of the peroxidase gene family provides new insights into fungal pathogenicity in Magnaporthe oryzaeQ35809095
Genome Sequences of Eight Aspergillus flavus spp. and One A. parasiticus sp., Isolated from Peanut Seeds in GeorgiaQ35990729
OxyR-regulated catalase CatB promotes the virulence in rice via detoxifying hydrogen peroxide in Xanthomonas oryzae pv. oryzaeQ36185947
Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortusQ36297476
Cytochrome P450s and other enzymes in drug metabolism and toxicityQ36439150
Acetyl-coenzyme A carboxylases: versatile targets for drug discoveryQ36597445
Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinaseQ36698566
Pesticides and the intoxication of wild animalsQ36755857
Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stressQ36828019
Glyoxalase pathway of trypanosomatid parasites: a promising chemotherapeutic targetQ37320211
Iron superoxide dismutase from Escherichia coli at 3.1-A resolution: a structure unlike that of copper/zinc protein at both monomer and dimer levelsQ37615874
What triggers grass endophytes to switch from mutualism to pathogenism?Q37855283
Drug targets in LeishmaniaQ37869809
PLP-dependent enzymes as potential drug targets for protozoan diseasesQ37925189
The glyoxalase pathway in protozoan parasites.Q38035468
Pathogen genome bioinformatics.Q38215572
BACE1 inhibitor drugs in clinical trials for Alzheimer's diseaseQ38332419
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmaizeQ11575
soybeanQ11006
tomatoQ23501
P304page(s)e0197511
P577publication date2018-05-25
P1433published inPLOS OneQ564954
P1476titleMining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
P478volume13

Reverse relations

Q90724277Crystal Structure-Based Exploration of Arginine-Containing Peptide Binding in the ADP-Ribosyltransferase Domain of the Type III Effector XopAI Proteincites workP2860

Search more.