What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia?

scientific article

What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/WPS.20516
P932PMC publication ID5980517
P698PubMed publication ID29856543

P50authorJose M RubioQ87796423
P2093author name stringChristoph U Correll
John M Kane
P2860cites workImpact of dopamine supersensitivity psychosis in treatment-resistant schizophrenia: An analysis of multi-factors predicting long-term prognosisQ40099438
Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactionsQ40136199
Mortality and Cumulative Exposure to Antipsychotics, Antidepressants, and Benzodiazepines in Patients With Schizophrenia: An Observational Follow-Up StudyQ40228281
Reduced all-cause mortality with antipsychotics and antidepressants compared to increased all-cause mortality with benzodiazepines in patients with schizophrenia observed in naturalistic treatment settings.Q40376876
Longitudinal study of brain morphology in first episode schizophreniaQ40718665
Does long term use of psychiatric drugs cause more harm than good?Q40928053
Premature Mortality Among Adults With Schizophrenia in the United States.Q41176091
Efficacy of Valbenazine (NBI-98854) in Treating Subjects with Tardive Dyskinesia and Schizophrenia or Schizoaffective DisorderQ41280845
Excess mortality in severe mental illness: 10-year population-based cohort study in rural EthiopiaQ41470845
Personalized Prediction of Psychosis: External Validation of the NAPLS-2 Psychosis Risk Calculator With the EDIPPP Project.Q41630931
Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysisQ41658698
D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysisQ42056580
Effect of lifestyle coaching versus care coordination versus treatment as usual in people with severe mental illness and overweight: Two-years follow-up of the randomized CHANGE trialQ42371406
Psychopharmacological Treatment in the RAISE-ETP Study: Outcomes of a Manual and Computer Decision Support System Based InterventionQ42692847
Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophreniaQ43149273
Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials.Q43694433
Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophreniaQ43787435
The 2009 schizophrenia PORT psychosocial treatment recommendations and summary statementsQ22242826
Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigorQ22242831
A Systematic Review of Mortality in SchizophreniaQ22253025
Recovery in Remitted First-Episode Psychosis at 7 Years of Follow-up of an Early Dose Reduction/Discontinuation or Maintenance Treatment StrategyQ23009758
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortiumQ23747506
A systematic review and meta-analysis of recovery in schizophreniaQ26859162
Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternativesQ26863435
Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?Q28109603
A randomized controlled trial of cognitive-behavioral therapy for persistent symptoms in schizophrenia resistant to medicationQ28144347
Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studiesQ28247669
Cerebral ventricular size and cognitive impairment in chronic schizophreniaQ28263146
Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysisQ28266069
Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysisQ28293647
Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas.Q30379171
Alterations in the hippocampus and thalamus in individuals at high risk for psychosis.Q30381309
The neuropathology of schizophrenia. A critical review of the data and their interpretationQ30573678
Laterality interacts with sex across the schizophrenia/bipolarity continuum: an interpretation of meta-analyses of structural MRI.Q30665408
Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry: what is happening in the schizophrenic brain?Q30695945
Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment ProgramQ30797835
The neuropathology of schizophrenia: A selective review of past studies and emerging themes in brain structure and cytoarchitectureQ30977022
Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studiesQ31023592
Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trialsQ33425007
The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statementsQ33566124
Differences in mortality and suicidal behaviour between treated and never-treated people with schizophrenia in rural ChinaQ33572071
Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controlsQ33670588
Real-world adherence assessment of lurasidone and other oral atypical antipsychotics among patients with schizophrenia: an administrative claims analysisQ39015229
Antipsychotic medication and long-term mortality risk in patients with schizophrenia; a systematic review and meta-analysisQ39233778
Tardive dyskinesia: review and updateQ40082882
Declining Clinical Course of Psychotic Disorders Over the Two Decades Following First Hospitalization: Evidence From the Suffolk County Mental Health ProjectQ40095934
Effect of prior treatment with antipsychotic long-acting injection on randomised clinical trial treatment outcomesQ44155989
Tardive Dyskinesia Prevalence in the Period of Second-Generation Antipsychotic Use: A Meta-AnalysisQ44435116
Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort studyQ44695213
Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting methodQ45295760
Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics.Q45988791
Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia - An observational 9-year follow-up studyQ46827879
Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia: A Meta-analysisQ47101583
Canadian Schizophrenia Guidelines: Schizophrenia and Other Psychotic Disorders with Coexisting Substance Use DisordersQ47274758
The Relationship Between Clinical and Personal Recovery in Patients With Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.Q47567149
Dopamine supersensitivity psychosis in schizophrenia: Concepts and implications in clinical practiceQ47618934
Stability and development of psychotic symptoms and the use of antipsychotic medication - long-term follow-upQ47755626
The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum.Q47945243
Brain Structural Abnormalities in a Group of Never-Medicated Patients With Long-Term Schizophrenia.Q48123812
Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometryQ48229217
Reversibility of brain tissue loss in anorexia nervosa assessed with a computerized Talairach 3-D proportional gridQ49096363
A prospective comparative study of risperidone long-acting injectable for treatment-resistant schizophrenia with dopamine supersensitivity psychosis.Q50652601
Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.Q50660859
Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: relapse rates and functional outcome.Q51903646
Neuroleptic withdrawal with remitted schizophrenics: a naturalistic follow-up study.Q51903792
Neuroleptic withdrawal in treatment-resistant patients with schizophrenia: tardive dyskinesia is not associated with supersensitive psychosis.Q51947455
Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy.Q51953902
Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study.Q52652401
Duration and Relevance of Untreated Psychiatric Disorders, 1: Psychotic Disorders.Q53366604
Accuracy of Clinician Assessments of Medication Status in the Emergency Setting: A Comparison of Clinician Assessment of Antipsychotic Usage and Plasma Level Determination.Q53393722
A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia.Q55054009
Characteristics of subjects with schizophrenia spectrum disorder with and without antipsychotic medication - a 10-year follow-up of the Northern Finland 1966 Birth Cohort study.Q55054896
SchizophreniaQ56959104
Apparent Cerebral Atrophy in Patients on Treatment with SteroidsQ57311455
Longitudinal Volume Reductions in People at High Genetic Risk of Schizophrenia as They Develop PsychosisQ57316778
Cardiovascular morbidity, mortality and pharmacotherapy in patients with schizophreniaQ57402860
Relapse and Rehospitalization During Maintenance Treatment of SchizophreniaQ57616603
Brain Volume Changes After Withdrawal of Atypical Antipsychotics in Patients With First-Episode SchizophreniaQ60610017
Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitizationQ63951925
Morbidity and mortality in tardive dyskinesia: associations in chronic schizophreniaQ69899091
A prospective study of tardive dyskinesia development: preliminary resultsQ72537133
Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectorsQ72734923
Tardive dyskinesia circa 2006Q80025605
A critique of the "ultra-high risk" and "transition" paradigmQ33670654
Randomized controlled trial of deutetrabenazine for tardive dyskinesia: The ARM-TD studyQ33714619
Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia.Q33814201
Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET studyQ33923683
Practice guideline for the treatment of patients with schizophrenia, second edition.Q33976372
Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapseQ33996824
11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study).Q34018491
Assessment of mortality and marital status of schizophrenic patients over a period of 13 yearsQ34034344
Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristicsQ34054683
Methylphenidate response, psychopathology and tardive dyskinesia as predictors of relapse in schizophreniaQ34317536
Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study.Q34337272
Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.Q34351095
Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatryQ34357174
Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brainQ34363450
Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. Anatomical likelihood estimation meta-analyses with sample size weighting.Q34415975
The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging StudiesQ34468314
Antipsychotic Maintenance Treatment: Time to Rethink?Q34488215
"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over timeQ34577698
Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care.Q34623350
Depot antipsychotic drugs. Place in therapyQ34719546
Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophreniaQ34861424
Oxidative mechanisms and tardive dyskinesiaQ35017644
Long-acting injectable versus oral antipsychotics in schizophrenia: a systematic review and meta-analysis of mirror-image studiesQ35042829
Low dose vs standard dose of antipsychotics for relapse prevention in schizophrenia: meta-analysisQ35065378
Clinical predictors of therapeutic response to antipsychotics in schizophreniaQ35109168
Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials.Q35165445
Switching from risperidone long-acting injectable to paliperidone long-acting injectable or oral antipsychotics: analysis of a Medicaid claims databaseQ35249595
Antipsychotic treatment and mortality in schizophreniaQ35369872
Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorderQ35754726
Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia.Q35777332
Quantifying clinical relevance in the treatment of schizophreniaQ35819467
Progressive Brain Atrophy and Cortical Thinning in Schizophrenia after Commencing Clozapine TreatmentQ35960362
Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysisQ36118736
Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countriesQ36200262
Different outcomes of never-treated and treated patients with schizophrenia: 14-year follow-up study in rural ChinaQ36333267
Cognitive behavior therapy for schizophreniaQ36412204
Reversible brain shrinkage in abstinent alcoholics, measured by MRI.Q36439736
The current unsatisfactory state of relapse prevention in schizophrenic psychoses--suggestions for improvementQ36537076
Antipsychotic adherence over time among patients receiving treatment for schizophrenia: a retrospective review.Q36654304
A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia.Q36692829
Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: A randomized, 1-year studyQ36784855
Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment.Q36838322
Physical illness and schizophrenia: a review of the literatureQ36962153
Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysisQ37015327
The CHANGE trial: no superiority of lifestyle coaching plus care coordination plus treatment as usual compared to treatment as usual alone in reducing risk of cardiovascular disease in adults with schizophrenia spectrum disorders and abdominal obesiQ37015355
Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjectsQ37131066
Effects of risperidone and olanzapine dose reduction on cognitive function in stable patients with schizophrenia: an open-label, randomized, controlled, pilot studyQ37131080
Non-adherence to medication in patients with psychotic disorders: epidemiology, contributing factors and management strategiesQ37236148
A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controlsQ37236162
Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: a meta-analysis of randomized trialsQ37451403
Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophreniaQ37584279
Metabolic and cardiovascular adverse effects associated with antipsychotic drugsQ37947095
Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithmsQ37966430
Risk factors for relapse following treatment for first episode psychosis: a systematic review and meta-analysis of longitudinal studies.Q38015565
Cognitive-behavioral therapy for medication-resistant psychosis: a meta-analytic reviewQ38200893
Clinically meaningful biomarkers for psychosis: a systematic and quantitative reviewQ38216050
A 28-week, randomized, double-blind study of olanzapine versus aripiprazole in the treatment of schizophrenia.Q38382821
Clinical outcome after antipsychotic treatment discontinuation in functionally recovered first-episode nonaffective psychosis individuals: a 3-year naturalistic follow-up studyQ38397353
Poor medication adherence and risk of relapse associated with continued cannabis use in patients with first-episode psychosis: a prospective analysis.Q38680307
A 20-Year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophreniaQ38708602
Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With SchizophreniaQ38737194
Reduced Thickness of the Anterior Cingulate Cortex in Individuals With an At-Risk Mental State Who Later Develop PsychosisQ38740436
The Long-Term Effects of Antipsychotic Medication on Clinical Course in SchizophreniaQ38803633
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disordersQ38815462
Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review.Q38855787
Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosisQ38918200
Safety and tolerability of long-acting injectable versus oral antipsychotics: A meta-analysis of randomized controlled studies comparing the same antipsychoticsQ38921307
Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysisQ38942045
Five-fold increased risk of relapse following breaks in antipsychotic treatment of first episode psychosisQ38981879
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectschizophreniaQ41112
P304page(s)149-160
P577publication date2018-06-01
P1433published inWorld PsychiatryQ8036083
P1476titleWhat is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia?
P478volume17

Reverse relations

cites work (P2860)
Q8659161020-year follow-up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)
Q90620603A critical analysis of recent data on the long-term outcome of antipsychotic treatment
Q99545938A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders
Q92441287A systematic review of genome-wide association studies of antipsychotic response
Q90116242Are we getting any better at staying better? The long view on relapse and recovery in first episode nonaffective psychosis and schizophrenia
Q97521512Barriers to stopping neuroleptic (antipsychotic) treatment in people with schizophrenia, psychosis or bipolar disorder
Q64910974Basic symptoms in offspring of parents with mood and psychotic disorders.
Q64910620Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.
Q90259306Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia
Q102388982Efficacy and safety of once-monthly Risperidone ISM® in schizophrenic patients with an acute exacerbation
Q90198639Exercise as Medicine for Mental and Substance Use Disorders: A Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes
Q100416111Identifying and validating subtypes within major psychiatric disorders based on frontal-posterior functional imbalance via deep learning
Q89572022Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia
Q93092613Keeping up with the therapeutic advances in schizophrenia: a review of novel and emerging pharmacological entities
Q60949949Less Medication Use in Inpatients With Severe Mental Illness Receiving a Multidisciplinary Lifestyle Enhancing Treatment. The MULTI Study III
Q91790829Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-to-head comparisons
Q98891298Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia
Q90264515Predictors for Antipsychotic Dosage Change in the First Year of Treatment in Schizophrenia Spectrum and Bipolar Disorders
Q91326524Psychiatric management of anti-NMDAR encephalitis: a cohort analysis
Q92695687Psychosis breakthrough on antipsychotic maintenance: results from a nationwide study
Q98627662Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis
Q57715244The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study
Q93192452The longitudinal effect of antipsychotic burden on psychosocial functioning in first-episode psychosis patients: the role of verbal memory
Q96773916The report of the joint WPA/CINP workgroup on the use and usefulness of antipsychotic medication in the treatment of schizophrenia
Q98289116The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: a clinical review
Q89842585The use of long-acting Aripiprazole in a multi-center, prospective, uncontrolled, open-label, cohort study in Germany: a report on global assessment of functioning and the WHO wellbeing index

Search more.