Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells.

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Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1103817501
P356DOI10.1038/S41598-018-25905-8
P932PMC publication ID5945622
P698PubMed publication ID29748552

P50authorNoemi Jiménez-RojoQ86317379
Aritz B García-ArribasQ91921462
Jesús SotQ95994734
P2093author name stringAlicia Alonso
Félix M Goñi
Cesar Martin
Jon V Busto
F Xabier Contreras
Hasna Ahyayauch
Adela Rendón-Ramírez
Bingen G Monasterio
Emilio J González-Ramírez
P2860cites workRegulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase CdeltaQ22253925
Identification of three new members of the phospholipid scramblase gene familyQ22254742
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolutionQ24595712
Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factorsQ24655395
Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytesQ24678667
A new generation of Ca2+ indicators with greatly improved fluorescence propertiesQ27860793
Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipidsQ28263490
Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipidQ28282149
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophagesQ29616355
Lead-induced procoagulant activation of erythrocytes through phosphatidylserine exposure may lead to thrombotic diseasesQ31093012
Identification of Mg2+ -dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosisQ33357486
Lipid translocation across the plasma membrane of mammalian cellsQ33710622
Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formationQ33852956
The phosphatidylserine receptor: a crucial molecular switch?Q34325344
Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodiesQ78580583
Anti-apoptotic pro-survival effect of clotrimazole in a normothermic ischemia reperfusion injury animal modelQ84531047
Biochemical evidence for Ca2+-independent functional activation of hPLSCR1 at low pHQ85644649
Effect of lead on the erythrocyte (Ca2+,Mg2+)-ATPase activity. Calmodulin involvementQ93520226
Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cellsQ48148726
In vitro effect of lead on Ca(2+)-ATPase in synaptic plasma membranes and microsomes of rat cerebral cortex and cerebellumQ49092601
Ceramide-Induced Lamellar Gel Phases in Fluid Cell Lipid ExtractsQ50231971
The influence of valinomycin induced membrane potential on erythrocyte shapeQ53031620
Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore.Q53913912
Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes.Q54182079
Sphingomyelinase cleavage of sphingomyelin in pure and mixed lipid membranes. Influence of the physical state of the sphingolipidQ63244829
Influence of lead ions on cation permeability in human red cell ghostsQ70114493
Relationship between the shape and the membrane potential of human red blood cellsQ70679114
Erythrocyte Delta-Aminolaevulic Acid Dehydrase Activity in AnaemiaQ71768868
Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathioneQ73442741
Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surfaceQ74325929
Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding siteQ77431280
Detergent-resistant, ceramide-enriched domains in sphingomyelin/ceramide bilayersQ34353229
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequencesQ34387889
The phagocytosis of apoptotic cellsQ34439302
Mechanisms and significance of eryptosisQ34557576
The therapeutic potential of modulating the ceramide/sphingomyelin pathwayQ34717833
Lead toxicity: current concernsQ34843521
Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.Q34987809
Molecular and cellular mechanisms of erythrocyte programmed cell death: impact on blood transfusionQ35078102
Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesisQ35096749
Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia.Q35979479
Micrometric segregation of fluorescent membrane lipids: relevance for endogenous lipids and biogenesis in erythrocytesQ36709590
Platelet procoagulant activity: physiological significance and mechanisms of exposureQ36928487
Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysisQ37091551
Transbilayer (flip-flop) lipid motion and lipid scrambling in membranesQ37665575
Ceramide in suicidal death of erythrocytesQ37760684
Ceramide in the regulation of eryptosis, the suicidal erythrocyte deathQ38338337
Role of Ca2+-activated K+ channels in human erythrocyte apoptosisQ38348428
Cholesterol interactions with ceramide and sphingomyelin.Q38821945
Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosisQ40011964
Shape transitions and lattice structuring of ceramide-enriched domains generated by sphingomyelinase in lipid monolayers.Q40311786
Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes.Q40311939
Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivativesQ40333068
Exposure of anionic phospholipids serves as anti-inflammatory and immunosuppressive signal--implications for antiphospholipid syndrome and systemic lupus erythematosus.Q40663830
Phospholipid scramblase activation pathways in lymphocytesQ40795369
Retention of water and potassium by erythrocytes prevents calcium-induced membrane rigidityQ40929660
Activation of recombinant human SK4 channels by metal cationsQ40963706
Functions of ceramide in coordinating cellular responses to stressQ41243489
Effects of chronic and acute lead treatments on the biophysical properties of erythrocyte membranes, and a comparison with model membranesQ41262493
Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical studyQ41398497
Lamellar gel (lβ) phases of ternary lipid composition containing ceramide and cholesterol.Q42004190
Cholesterol-rich fluid membranes solubilize ceramide domains: implications for the structure and dynamics of mammalian intracellular and plasma membranes.Q42087759
A cholesterol recognition motif in human phospholipid scramblase 1.Q42094385
Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cellsQ42143355
Lipid peroxidation and concentration of glutathione in erythrocytes from workers exposed to leadQ42287537
S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to leadQ42725655
Eryptosis in lead-exposed workers.Q43325986
Biochemical evidence for lead and mercury induced transbilayer movement of phospholipids mediated by human phospholipid scramblase 1.Q43421807
Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathiesQ43430531
Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblastsQ43507062
The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca²⁺-binding.Q43672114
Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondriaQ43830912
Effects of sample temperature on red blood cell shape in septic patients.Q44102916
Relationship between oxidative stress, pathology, and behavioral signs of lead poisoning in mallards.Q44506786
PbCl2‐induced hyperpolarization of rat thymocytes: Involvement of charybdotoxin‐sensitive K+ channelsQ44591842
Stimulation of erythrocyte phosphatidylserine exposure by lead ionsQ45219054
The single C-terminal helix of human phospholipid scramblase 1 is required for membrane insertion and scrambling activity.Q46092293
mTORC2 Promotes Tumorigenesis via Lipid SynthesisQ47302489
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectceramidesQ424213
P304page(s)7456
P577publication date2018-05-10
P1433published inScientific ReportsQ2261792
P1476titlePb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells.
P478volume8

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cites work (P2860)
Q64882674Epitaxial Graphene Sensors Combined with 3D-Printed Microfluidic Chip for Heavy Metals Detection.
Q91173363FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
Q58582462Understanding Graphene Response to Neutral and Charged Lead Species: Theory and Experiment