Mitochondrial Complex I activity signals antioxidant response through ERK5.

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Mitochondrial Complex I activity signals antioxidant response through ERK5. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1103798178
P356DOI10.1038/S41598-018-23884-4
P932PMC publication ID5943249
P698PubMed publication ID29743487

P50authorJosé Antonio EnríquezQ40627615
Francesco BertoliniQ56850281
Martin VillalbaQ57425448
Sabine Gerbal-ChaloinQ57866344
Javier HernandezQ59677400
Martine Daujat-ChavanieuQ59690301
Nerea Allende-VegaQ64788606
Cécile DelettreQ85171096
P2093author name stringCharles-Henri Lecellier
Guillaume Cartron
José M Cuezva
Giovanna Talarico
Stefania Orecchioni
Dang-Nghiem Vo
Sana Belkhala
Alberto Anel
Johan Garaude
Delphine Gitenay
Abrar Ul Haq Khan
Claire Gondeau
P2860cites workAn integrated encyclopedia of DNA elements in the human genomeQ22122150
Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activationQ24300443
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1Q24548255
Big mitogen-activated kinase regulates multiple members of the MEF2 protein familyQ28137985
Nrf2 protects mitochondrial decay by oxidative stressQ28396758
Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinaseQ28583309
Supercomplex assembly determines electron flux in the mitochondrial electron transport chainQ28590886
Chemical metabolic inhibitors for the treatment of blood-borne cancersQ28822335
Nrf2: friend or foe for chemoprevention?Q33575690
ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domainQ33605384
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleusQ33873104
Evolution meets disease: penetrance and functional epistasis of mitochondrial tRNA mutationsQ33886174
Mitochondrial Complex I: structural and functional aspectsQ33997495
Detection of interacting transcription factors in human tissues using predicted DNA binding affinityQ34173996
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cellsQ34205774
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinomaQ34225915
The NF-κB member p65 controls glutamine metabolism through miR-23a.Q34277479
Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cellsQ34297004
MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cellsQ35201839
Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK PathwayQ35814106
The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolismQ36326369
Nuclear control of respiratory gene expression in mammalian cellsQ36331586
Human Leukemic Cells performing Oxidative Phosphorylation (OXPHOS) Generate an Antioxidant Response Independently of Reactive Oxygen species (ROS) ProductionQ36538773
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiencyQ36742515
Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal LifespanQ36809576
ERK5/BMK1 is a novel target of the tumor suppressor VHL: implication in clear cell renal carcinoma.Q36879241
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardiumQ37238575
Flow activation of AMP-activated protein kinase in vascular endothelium leads to Krüppel-like factor 2 expressionQ37396786
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cellsQ37749030
Flow shear stress and atherosclerosis: a matter of site specificityQ37807049
From tumor cell metabolism to tumor immune escapeQ38008488
The emerging role of Nrf2 in mitochondrial functionQ38481021
Redox Homeostasis and Mitochondrial Dynamics.Q38545789
The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment.Q38749584
The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.Q38780229
Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic stateQ39509449
Oxidative phosphorylation induces de novo expression of the MHC class I in tumor cells through the ERK5 pathway.Q39664735
Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.Q39695465
ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis.Q39876512
ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo.Q40206582
Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.Q40273686
The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 PathwayQ41632623
Nrf2 regulates ROS production by mitochondria and NADPH oxidaseQ41883957
MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.Q45233235
Acute exercise stress promotes Ref1/Nrf2 signalling and increases mitochondrial antioxidant activity in skeletal muscleQ46622157
SUMOylation regulates the transcriptional activity of JunB in T lymphocytes.Q46634753
The role of ERK5 in T-cell signalling.Q46826626
The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.Q51536210
Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells.Q54348750
Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without itQ59195029
Human hepatocyte cultureQ83830231
Big mitogen-activated protein kinase 1 protects cultured rat aortic smooth muscle cells from oxidative damageQ84151018
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)7420
P577publication date2018-05-09
P1433published inScientific ReportsQ2261792
P1476titleMitochondrial Complex I activity signals antioxidant response through ERK5.
P478volume8

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cites work (P2860)
Q64065870Impact of ERK5 on the Hallmarks of Cancer
Q100992525MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation
Q64078232Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells
Q92932089Mitochondrial stress management: a dynamic journey
Q60951217PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway
Q89805787Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

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