Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins.

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Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1007418
P932PMC publication ID5991416
P698PubMed publication ID29795547

P50authorErika ShorQ63386749
Kelsey Rae PerryQ88797292
Sandya SubramanianQ88797293
Michael WeinreichQ88797296
Catherine A FoxQ88797297
Jef D BoekeQ37391166
P2093author name stringEdel M Hyland
Jessica Kenworthy
FuJung Chang
Julie Chueng
Timothy A Hoggard
P2860cites workConserved nucleosome positioning defines replication originsQ24595251
The molecular topography of silenced chromatin in Saccharomyces cerevisiaeQ24605397
ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.Q24633457
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replicationQ24647097
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensingQ24647856
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-riboseQ24675630
Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79Q27673259
Structural Basis of Silencing: Sir3 BAH Domain in Complex with a Nucleosome at 3.0 A ResolutionQ27675642
Chromatin Constrains the Initiation and Elongation of DNA Replication.Q51003935
An ARS element inhibits DNA replication through a SIR2-dependent mechanism.Q53480696
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
Histone acetylation regulates the time of replication origin firingQ27930649
Regulation of ribosomal DNA amplification by the TOR pathwayQ27930664
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.Q27931475
A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.Q27932277
A novel yeast silencer. the 2mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activityQ27933311
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA associationQ27933908
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylasesQ27934108
Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclinQ27937313
The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replicationQ27939471
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexQ28241786
Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interactionQ28756488
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeastQ29618830
An unusual form of transcriptional silencing in yeast ribosomal DNAQ29618831
The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiaeQ30276142
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiaeQ33226323
The DNA damage response pathway contributes to the stability of chromosome III derivatives lacking efficient replicatorsQ33769550
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespanQ34625412
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeastQ34662036
Defining the replication program through the chromatin landscapeQ34780596
Persistence of an alternate chromatin structure at silenced loci in vitroQ34807214
The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatinQ34812174
A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeastQ34998333
Widespread misinterpretable ChIP-seq bias in yeastQ35071005
A dual role of H4K16 acetylation in the establishment of yeast silent chromatin.Q35161966
Yeast heterochromatin is a dynamic structure that requires silencers continuouslyQ35186639
Telomeric chromatin modulates replication timing near chromosome endsQ35187055
Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase IQ35211962
Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeastQ35642142
Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.Q35989395
ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo.Q36200857
Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.Q36752433
Chromosome Duplication in Saccharomyces cerevisiae.Q37076776
The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersionQ37150874
Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteinsQ37319659
SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequencesQ37598946
Genetic and epigenetic determinants of DNA replication origins, position and activationQ38094410
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.Q38317749
Identification of a functional domain within the essential core of histone H3 that is required for telomeric and HM silencing in Saccharomyces cerevisiaeQ39124565
High-resolution chromatin dynamics during a yeast stress responseQ39847543
Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast.Q39938475
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.Q40035632
Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.Q40970716
Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork RatesQ41072300
Phosphorylated SIRT1 associates with replication origins to prevent excess replication initiation and preserve genomic stabilityQ41510682
Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome lossQ41831344
Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localizationQ41872924
Nucleosome occupancy as a novel chromatin parameter for replication origin functionsQ42145400
Nucleosomes influence multiple steps during replication initiationQ42290808
DNA replication stress restricts ribosomal DNA copy number.Q42365210
Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way.Q42491877
A role for a replicator dominance mechanism in silencingQ42677257
Dynamic changes in histone acetylation regulate origins of DNA replicationQ42700642
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.Q42702121
Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.Q43178320
Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timingQ43415186
An origin-deficient yeast artificial chromosome triggers a cell cycle checkpointQ43597288
Chromatin regulates origin activity in Drosophila follicle cellsQ44978894
Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loadersQ47693928
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P304page(s)e1007418
P577publication date2018-05-24
P1433published inPLOS GeneticsQ1893441
P1476titleYeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins
P478volume14

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cites work (P2860)
Q92176968Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of Saccharomyces cerevisiae
Q64096730Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes
Q98568521The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

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