The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication

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The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.1173204
P3181OpenCitations bibliographic resource ID4332394
P932PMC publication ID387417
P698PubMed publication ID15082529
P5875ResearchGate publication ID8619814

P2093author name stringDonald L Pappas
Michael Weinreich
Ryan Frisch
P2860cites workNegative control of p53 by Sir2alpha promotes cell survival under stressQ24291828
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseQ24291829
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylaseQ24296836
Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiaeQ24532215
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcriptionQ24545711
The origin recognition complex interacts with a bipartite DNA binding site within yeast replicatorsQ24563569
A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiaeQ24594481
Mitotic and meiotic stability of linear plasmids in yeastQ24599900
Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replicationQ24685710
Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint controlQ27627450
Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase IIIQ27634553
Yeast origin recognition complex functions in transcription silencing and DNA replicationQ61942289
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genomeQ72295197
Structure and function of the BAH-containing domain of Orc1p in epigenetic silencingQ27639534
The structure of bacterial DnaA: implications for general mechanisms underlying DNA replication initiationQ27639653
Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion proteinQ27765268
Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATPQ27765278
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencingQ27929529
Histone acetylation regulates the time of replication origin firingQ27930649
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phaseQ27930849
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeastQ27931174
Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKsQ27931263
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.Q27931475
Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylasesQ27931861
Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast.Q27932142
A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.Q27932277
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylasesQ27934108
Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeastQ27936518
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeastQ27936734
Role of interactions between the origin recognition complex and SIR1 in transcriptional silencingQ27937028
Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complexQ27937157
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stabilityQ27937288
G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleusQ27937350
Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrityQ27937617
Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere lengthQ27938798
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sitesQ28131597
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcriptionQ28131683
AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexesQ28131706
DNA replication in eukaryotic cellsQ28131747
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteinsQ28139564
Cyclin-dependent kinases prevent DNA re-replication through multiple mechanismsQ28204020
The origin recognition complex, SIR1, and the S phase requirement for silencingQ28239695
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexQ28241786
The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencingQ28291160
A yeast chromosomal origin of DNA replication defined by multiple functional elementsQ28679255
Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.Q29465402
The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiaeQ29614854
Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeastQ29614857
Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolusQ29615267
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeastQ29618830
An unusual form of transcriptional silencing in yeast ribosomal DNAQ29618831
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient miceQ29619786
RNA polymerase I propagates unidirectional spreading of rDNA silent chromatinQ30310369
Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locusQ30479469
Xenopus Cdc6 performs separate functions in initiating DNA replicationQ33608362
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae.Q33893339
Sir2 links chromatin silencing, metabolism, and agingQ33901751
Completion of replication map of Saccharomyces cerevisiae chromosome III.Q33948459
Enzymatic activities of Sir2 and chromatin silencingQ34180696
Histone acetylation and deacetylation in yeastQ34187792
Cell cycle control of DNA replication.Q34408864
The molecular biology of the SIR proteinsQ34448539
Histone deacetylases and cancer: causes and therapiesQ34570082
A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiaeQ34606092
The role of nucleotide binding and hydrolysis in the function of the fission yeast cdc18(+) gene productQ34606637
Paradigms and pitfalls of yeast longevity researchQ34667086
The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatinQ34812174
Motors and switches: AAA+ machines within the replisome.Q34988324
Telomeric chromatin modulates replication timing near chromosome endsQ35187055
The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencingQ36235711
Locus specificity determinants in the multifunctional yeast silencing protein Sir2Q36246286
Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiaeQ36937916
Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylationQ39674793
Ku complex controls the replication time of DNA in telomere regions.Q39864326
The structure and function of yeast ARS elementsQ40797768
Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cellsQ41212656
Nucleosome positioning can affect the function of a cis-acting DNA element in vivoQ41241827
Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome lossQ41831344
Acetylation of the yeast histone H4 N terminus regulates its binding to heterochromatin protein SIR3.Q43803659
A yeast origin of replication is activated late in S phaseQ44228986
The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle.Q45345061
Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotesQ46408897
Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiaeQ46889661
Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loadersQ47693928
Replication dynamics of the yeast genome.Q52053905
Nucleosomes positioned by ORC facilitate the initiation of DNA replication.Q52542122
RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.Q54655346
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectNAD-dependent histone deacetylase SIR2 YDL042CQ27551037
P304page(s)769-81
P577publication date2004-04-01
P1433published inGenes & DevelopmentQ1524533
P1476titleThe NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication
P478volume18

Reverse relations

cites work (P2860)
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