Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1.

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Fission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1. is …
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P356DOI10.1038/S41598-018-26476-4
P932PMC publication ID5981605
P698PubMed publication ID29855479

P50authorDevyani HaldarQ88945140
P2093author name stringLahiri Konada
Raghavendra Vadla
Shalini Aricthota
P2860cites workSIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activityQ24294017
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosisQ24338619
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondriaQ24536184
Histone H3 lysine 56 acetylation and the response to DNA replication fork damageQ24612284
CBP/p300-mediated acetylation of histone H3 on lysine 56Q24657910
Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replicationQ24685063
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyQ26796576
Structural basis for sirtuin activity and inhibitionQ26823308
Sirtuin-dependent epigenetic regulation in the maintenance of genome integrityQ27026871
A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome.Q27683670
The role of chromatin during transcriptionQ27860995
Control of replication initiation by the Sum1/Rfm1/Hst1 histone deacetylaseQ27931914
Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assemblyQ27932260
A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.Q27935272
Ctf4p facilitates Mcm10p to promote DNA replication in budding yeastQ27935864
CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiaeQ27937524
The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replicationQ27939471
The Sir2 family of protein deacetylasesQ28266179
p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammalsQ28286413
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1Q28512371
Molecular genetic analysis of fission yeast Schizosaccharomyces pombeQ29547703
Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpointQ29614219
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction mapQ29618911
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menQ29619117
The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase.Q53588143
On the slowing of S phase in response to DNA damage in fission yeast.Q53636335
Ctf4 coordinates the progression of helicase and DNA polymerase alpha.Q54741740
Rad22 protein, a rad52 homologue in Schizosaccharomyces pombe, binds to DNA double-strand breaksQ64388428
A simple and efficient method for the isolation of total RNA from the fission yeast Schizosaccharomyces pombeQ71167371
Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formationQ80334271
Tools to tackle protein acetylationQ84815973
Yeast sirtuins and the regulation of agingQ30407415
Construction and characterization of a series of vectors for Schizosaccharomyces pombeQ33229621
A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeastQ33336581
Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survivalQ33718702
CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genesQ33971271
Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forksQ34079196
mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregationQ34100729
A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.Q34433751
Transcription Regulation by Class III Histone Deacetylases (HDACs)-Sirtuins.Q34497747
Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complexQ34561912
The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombeQ34561974
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeastQ34662036
Replisome function during replicative stress is modulated by histone h3 lysine 56 acetylation through Ctf4.Q35342649
Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint responseQ35789576
Histones and histone modificationsQ35842800
The biochemistry of sirtuins.Q36498332
Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation.Q36769537
Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damageQ36836967
The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functionsQ36917690
Checkpoint-dependent regulation of origin firing and replication fork movement in response to DNA damage in fission yeastQ37033647
Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.Q37065125
Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteinsQ37354105
Regulation of DNA replication by the S-phase DNA damage checkpointQ37540336
Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencingQ38302551
Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylationQ38608229
Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG HelicaseQ39616391
Roles of human AND-1 in chromosome transactions in S phaseQ39852067
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1.Q39940510
Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR.Q40240578
The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiaeQ40412146
Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progressionQ41772663
RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.Q41819504
Sirtuins at a glance.Q42650245
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repairQ43217577
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.Q43796805
Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delayQ46171963
Genetic and physical interactions between Schizosaccharomyces pombe Mcl1 and Rad2, Dna2 and DNA polymerase alpha: evidence for a multifunctional role of Mcl1 in DNA replication and repair.Q46509031
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)8496
P577publication date2018-05-31
P1433published inScientific ReportsQ2261792
P1476titleFission Yeast Sirtuin Hst4 Functions in Preserving Genomic Integrity by Regulating Replisome Component Mcl1
P478volume8